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Symmetrical Bispyridinium Compounds Act as Open Channel Blockers of Cation-Selective Ion Channels. , Haufe Y., ACS Pharmacol Transl Sci. March 8, 2024; 7 (3): 771-786.
Selective block of human Kv1.1 channels and an epilepsy-associated gain-of-function mutation by AETX-K peptide. , Zhao R., FASEB J. January 1, 2024; 38 (1): e23381.
Using Xenopus to discover new candidate genes involved in BOR and other congenital hearing loss syndromes. , Neal SJ., J Exp Zool B Mol Dev Evol. October 13, 2023;
Time-resolved quantitative proteomic analysis of the developing Xenopus otic vesicle reveals putative congenital hearing loss candidates. , Baxi AB., iScience. September 15, 2023; 26 (9): 107665.
Divergence between Hemichannel and Gap Junction Permeabilities of Connexin 30 and 26. , Xu J., Life (Basel). January 31, 2023; 13 (2):
Rack1 regulates cellular patterning and polarity in the mouse cochlea. , Yu D., Exp Cell Res. December 15, 2022; 421 (2): 113387.
Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism. , Frampton DJA., Elife. June 1, 2022; 11
Inhibition of the Aquaporin-1 Cation Conductance by Selected Furan Compounds Reduces Red Blood Cell Sickling. , Chow PH., Front Pharmacol. October 1, 2021; 12 794791.
The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site. , Gulsevin A., Toxins (Basel). August 10, 2021; 13 (8):
Acute consequences of a unilateral VIIIth nerve transection on vestibulo-ocular and optokinetic reflexes in Xenopus laevis tadpoles. , Soupiadou P., J Neurol. December 1, 2020; 267 (Suppl 1): 62-75.
An In Vitro Study on Prestin Analog Gene in the Bullfrog Hearing Organs. , Wang Z., Neural Plast. July 2, 2020; 2020 3570732.
5-Hydroxymethyl-Furfural and Structurally Related Compounds Block the Ion Conductance in Human Aquaporin-1 Channels and Slow Cancer Cell Migration and Invasion. , Chow PH., Mol Pharmacol. July 1, 2020; 98 (1): 38-48.
Desensitization of NMDA channels requires ligand binding to both GluN1 and GluN2 subunits to constrict the pore beside the activation gate. , Chen YS ., J Neurochem. June 1, 2020; 153 (5): 549-566.
A lower X-gate in TASK channels traps inhibitors within the vestibule. , Rödström KEJ., Nature. June 1, 2020; 582 (7812): 443-447.
Tuning Scorpion Toxin Selectivity: Switching From KV1.1 to KV1.3. , Gigolaev AM., Front Pharmacol. April 7, 2020; 11 1010.
Structural Determinants Mediating Tertiapin Block of Neuronal Kir3.2 Channels. , Patel D., Biochemistry. February 25, 2020; 59 (7): 836-850.
Aquaporin-7: A Dynamic Aquaglyceroporin With Greater Water and Glycerol Permeability Than Its Bacterial Homolog GlpF. , Moss FJ., Front Physiol. January 1, 2020; 11 728.
Structural determinants underlying permeant discrimination of the Cx43 hemichannel. , Nielsen BS., J Biol Chem. November 8, 2019; 294 (45): 16789-16803.
Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization. , McCarthy AE., Cell. October 17, 2019; 179 (3): 659-670.e13.
Identification of Aethina tumida Kir Channels as Putative Targets of the Bee Venom Peptide Tertiapin Using Structure-Based Virtual Screening Methods. , Doupnik CA., Toxins (Basel). September 19, 2019; 11 (9):
Topologically correct central projections of tetrapod inner ear afferents require Fzd3. , Duncan JS., Sci Rep. July 16, 2019; 9 (1): 10298.
Trans-toxin ion-sensitivity of charybdotoxin-blocked potassium-channels reveals unbinding transitional states. , Moldenhauer H., Elife. July 4, 2019; 8
A Critical E-box in Barhl1 3' Enhancer Is Essential for Auditory Hair Cell Differentiation. , Hou K., Cells. May 15, 2019; 8 (5):
A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels. , Wu Y., Elife. May 2, 2019; 8
Mutations in the palm domain disrupt modulation of acid-sensing ion channel 1a currents by neuropeptides. , Bargeton B., Sci Rep. February 22, 2019; 9 (1): 2599.
Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. , Bisignano P., Nat Commun. December 7, 2018; 9 (1): 5245.
Transplantation of Ears Provides Insights into Inner Ear Afferent Pathfinding Properties. , Gordy C., Dev Neurobiol. November 1, 2018; 78 (11): 1064-1080.
The degenerin region of the human bile acid-sensitive ion channel (BASIC) is involved in channel inhibition by calcium and activation by bile acids. , Ilyaskin AV., Pflugers Arch. July 1, 2018; 470 (7): 1087-1102.
Microvascular anatomy of the brain of the adult pipid frog, Xenopus laevis (Daudin): A scanning electron microscopic study of vascular corrosion casts. , Lametschwandtner A., J Morphol. July 1, 2018; 279 (7): 950-969.
Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation. , Zhang Z ., Elife. May 10, 2018; 7
The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels. , García IE., J Gen Physiol. May 7, 2018; 150 (5): 697-711.
High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics. , Mager T., Nat Commun. May 1, 2018; 9 (1): 1750.
Mechanism of NMDA receptor channel block by MK-801 and memantine. , Song X., Nature. April 1, 2018; 556 (7702): 515-519.
Sonic hedgehog antagonists reduce size and alter patterning of the frog inner ear. , Zarei S., Dev Neurobiol. December 1, 2017; 77 (12): 1385-1400.
Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1. , Gorraitz E., Proc Natl Acad Sci U S A. November 14, 2017; 114 (46): E9980-E9988.
Moving or being moved: that makes a difference. , Straka H ., J Neurol. October 1, 2017; 264 (Suppl 1): 28-33.
Modulation of the FMRFamide-gated Na+ channel by external Ca2. , Fujimoto A., Pflugers Arch. October 1, 2017; 469 (10): 1335-1347.
Expression and Purification of the Pain Receptor TRPV1 for Spectroscopic Analysis. , Velisetty P., Sci Rep. August 29, 2017; 7 (1): 9861.
Molecular Structure of the Human CFTR Ion Channel. , Liu F., Cell. March 23, 2017; 169 (1): 85-95.e8.
Spectrin βV adaptive mutations and changes in subcellular location correlate with emergence of hair cell electromotility in mammalians. , Cortese M., Proc Natl Acad Sci U S A. February 21, 2017; 114 (8): 2054-2059.
Structural determinants of NH3 and NH4+ transport by mouse Rhbg, a renal Rh glycoprotein. , Abdulnour-Nakhoul S., Am J Physiol Renal Physiol. December 1, 2016; 311 (6): F1280-F1293.
Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine. , Nys M., Proc Natl Acad Sci U S A. October 25, 2016; 113 (43): E6696-E6703.
Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels. , Sanchez HA., J Gen Physiol. July 1, 2016; 148 (1): 25-42.
Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION. , Horenstein NA., J Biol Chem. March 4, 2016; 291 (10): 5049-67.
The Ascaris suum nicotinic receptor, ACR-16, as a drug target: Four novel negative allosteric modulators from virtual screening. , Zheng F., Int J Parasitol Drugs Drug Resist. February 10, 2016; 6 (1): 60-73.
RNA-Seq and microarray analysis of the Xenopus inner ear transcriptome discloses orthologous OMIM(®) genes for hereditary disorders of hearing and balance. , Ramírez-Gordillo D., BMC Res Notes. November 18, 2015; 8 691.
Semicircular canal-dependent developmental tuning of translational vestibulo-ocular reflexes in Xenopus laevis. , Branoner F., Dev Neurobiol. October 1, 2015; 75 (10): 1051-67.
The Human Acid-Sensing Ion Channel ASIC1a: Evidence for a Homotetrameric Assembly State at the Cell Surface. , van Bemmelen MX., PLoS One. August 4, 2015; 10 (8): e0135191.
Pore dimensions and the role of occupancy in unitary conductance of Shaker K channels. , Díaz-Franulic I., J Gen Physiol. August 1, 2015; 146 (2): 133-46.
A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels. , Napolitano LM., Proc Natl Acad Sci U S A. July 7, 2015; 112 (27): E3619-28.