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Discovery of a genetic module essential for assigning left- right asymmetry in humans and ancestral vertebrates. , Szenker-Ravi E., Nat Genet. January 1, 2022; 54 (1): 62-72.
Bicc1 and Dicer regulate left- right patterning through post-transcriptional control of the Nodal inhibitor Dand5. , Maerker M., Nat Commun. September 16, 2021; 12 (1): 5482.
A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts. , Grosch M., J Cell Sci. August 15, 2021; 134 (16):
Aquatic models of human ciliary diseases. , Corkins ME., Genesis. February 1, 2021; 59 (1-2): e23410.
Comparative gene expression profiling between optic nerve and spinal cord injury in Xenopus laevis reveals a core set of genes inherent in successful regeneration of vertebrate central nervous system axons. , Belrose JL., BMC Genomics. August 5, 2020; 21 (1): 540.
Trpc1 as the Missing Link Between the Bmp and Ca2+ Signalling Pathways During Neural Specification in Amphibians. , Néant I ., Sci Rep. November 5, 2019; 9 (1): 16049.
The ion channel function of polycystin-1 in the polycystin-1/polycystin-2 complex. , Wang Z., EMBO Rep. November 5, 2019; 20 (11): e48336.
Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals. , Gentsch GE ., Nat Commun. September 19, 2019; 10 (1): 4269.
Mechanical strain, novel genes and evolutionary insights: news from the frog left- right organizer. , Blum M ., Curr Opin Genet Dev. June 1, 2019; 56 8-14.
A PKD1L3 splice variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site. , Kashyap P., Biochem Biophys Res Commun. May 14, 2019; 512 (4): 812-818.
A dual function of FGF signaling in Xenopus left- right axis formation. , Schneider I., Development. May 10, 2019; 146 (9):
Characterization of potential TRPP2 regulating proteins in early Xenopus embryos. , Futel M., J Cell Biochem. December 1, 2018; 119 (12): 10338-10350.
Premotor Neuron Divergence Reflects Vocal Evolution. , Barkan CL., J Neurosci. June 6, 2018; 38 (23): 5325-5337.
An Early Function of Polycystin-2 for Left- Right Organizer Induction in Xenopus. , Vick P ., iScience. April 27, 2018; 2 76-85.
The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex. , Feng S., J Am Soc Nephrol. October 1, 2017; 28 (10): 2973-2984.
TRPP2-dependent Ca2+ signaling in dorso- lateral mesoderm is required for kidney field establishment in Xenopus. , Futel M., J Cell Sci. March 1, 2015; 128 (5): 888-99.
The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality. , Boskovski MT., Nature. December 19, 2013; 504 (7480): 456-9.
Left- right asymmetry: lessons from Cancún. , Burdine RD., Development. November 1, 2013; 140 (22): 4465-70.
Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation. , Streets AJ., Hum Mol Genet. May 15, 2013; 22 (10): 1924-39.
Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. , Yu Y., Nat Commun. January 1, 2012; 3 1252.
Polycystin-2 activity is controlled by transcriptional coactivator with PDZ binding motif and PALS1-associated tight junction protein. , Duning K., J Biol Chem. October 29, 2010; 285 (44): 33584-8.
Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1. , Woodward OM., PLoS One. August 23, 2010; 5 (8): e12305.
The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity. , Tran U ., Development. April 1, 2010; 137 (7): 1107-16.
Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease. , Li Y., J Biol Chem. December 25, 2009; 284 (52): 36431-36441.
Structural and molecular basis of the assembly of the TRPP2/ PKD1 complex. , Yu Y., Proc Natl Acad Sci U S A. July 14, 2009; 106 (28): 11558-63.
TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum. , Wegierski T., EMBO J. March 4, 2009; 28 (5): 490-9.
Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants. , Sullivan-Brown J., Dev Biol. February 15, 2008; 314 (2): 261-75.
Cilia-driven leftward flow determines laterality in Xenopus. , Schweickert A ., Curr Biol. January 9, 2007; 17 (1): 60-6.
Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head. , Butscheid Y., Mol Reprod Dev. March 1, 2006; 73 (3): 350-60.
Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling. , Li Y., J Biol Chem. December 16, 2005; 280 (50): 41298-306.
Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. , Bisgrove BW., Dev Biol. November 15, 2005; 287 (2): 274-88.
Localization and loss-of-function implicates ciliary proteins in early, cytoplasmic roles in left- right asymmetry. , Qiu D., Dev Dyn. September 1, 2005; 234 (1): 176-89.
Xenopus TRPN1 ( NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner- ear hair cells. , Shin JB., Proc Natl Acad Sci U S A. August 30, 2005; 102 (35): 12572-7.
A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. , Sun Z., Development. August 1, 2004; 131 (16): 4085-93.
Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. , Cano DA., Development. July 1, 2004; 131 (14): 3457-67.
Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. , Luo Y., Mol Cell Biol. April 1, 2003; 23 (7): 2600-7.
Polycystin-2 associates with tropomyosin-1, an actin microfilament component. , Li Q ., J Mol Biol. January 31, 2003; 325 (5): 949-62.
Polycystin-2 interacts with troponin I, an angiogenesis inhibitor. , Li Q ., Biochemistry. January 21, 2003; 42 (2): 450-7.
Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X. , Chen XZ., Biochem Biophys Res Commun. April 20, 2001; 282 (5): 1251-6.
Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease. , Vassilev PM., Biochem Biophys Res Commun. March 23, 2001; 282 (1): 341-50.
Differences in pH optima and calcium requirements for maturation of the prohormone convertases PC2 and PC3 indicates different intracellular locations for these events. , Shennan KI., J Biol Chem. January 20, 1995; 270 (3): 1402-7.
Autocatalytic maturation of the prohormone convertase PC2. , Matthews G., J Biol Chem. January 7, 1994; 269 (1): 588-92.