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Functional Characterization of a Spectrum of Novel Romano-Ward Syndrome KCNQ1 Variants. , Rinné S., Int J Mol Sci. January 10, 2023; 24 (2):
Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels. , Zou X., Front Physiol. January 1, 2022; 13 902224.
Molecular Mechanism of Autosomal Recessive Long QT-Syndrome 1 without Deafness. , Oertli A., Int J Mol Sci. January 23, 2021; 22 (3):
Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state. , Taylor KC., Elife. February 25, 2020; 9
ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling. , Hou P., Elife. July 22, 2019; 8
Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation. , De Silva AM., Sci Adv. November 14, 2018; 4 (11): eaav0824.
Direct neurotransmitter activation of voltage-gated potassium channels. , Manville RW., Nat Commun. May 10, 2018; 9 (1): 1847.
High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance. , Steffensen AB., Sci Rep. January 12, 2015; 5 10009.
Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1. , Aidery P., Gene. December 10, 2012; 511 (1): 26-33.
KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue. , Nakajo K., J Gen Physiol. November 1, 2011; 138 (5): 521-35.
Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway. , Blackiston D ., Dis Model Mech. January 1, 2011; 4 (1): 67-85.
State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation. , Wu D., J Gen Physiol. June 1, 2010; 135 (6): 595-606.
Discovery of a novel activator of KCNQ1- KCNE1 K channel complexes. , Mruk K., PLoS One. January 1, 2009; 4 (1): e4236.
Long QT syndrome-associated mutations in the voltage sensor of I(Ks) channels. , Henrion U., Cell Physiol Biochem. January 1, 2009; 24 (1-2): 11-6.
Modulation of potassium channel function confers a hyperproliferative invasive phenotype on embryonic stem cells. , Morokuma J., Proc Natl Acad Sci U S A. October 28, 2008; 105 (43): 16608-13.
KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains. , Xu X., J Gen Physiol. June 1, 2008; 131 (6): 589-603.
KCNQ1 and KCNE1 K+ channel components are involved in early left- right patterning in Xenopus laevis embryos. , Morokuma J., Cell Physiol Biochem. January 1, 2008; 21 (5-6): 357-72.
Upregulation of KCNE1 induces QT interval prolongation in patients with chronic heart failure. , Watanabe E., Circ J. April 1, 2007; 71 (4): 471-8.
KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels. , Gage SD., J Gen Physiol. December 1, 2004; 124 (6): 759-71.
A spectrum of functional effects for disease causing mutations in the Jervell and Lange-Nielsen syndrome. , Huang L., Cardiovasc Res. September 1, 2001; 51 (4): 670-80.
Inhibition of IKs channels by HMR 1556. , Gögelein H., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2000; 362 (6): 480-8.
MinK subdomains that mediate modulation of and association with KvLQT1. , Tapper AR., J Gen Physiol. September 1, 2000; 116 (3): 379-90.