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Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer. , Levin M ., Cell. April 15, 2021;
N6-modified cAMP derivatives that activate protein kinase A also act as full agonists of murine HCN2 channels. , Leypold T., J Biol Chem. November 22, 2019; 294 (47): 17978-17987.
Incorporation of one N-glycosylation-deficient subunit within a tetramer of HCN2 channel is tolerated. , Kaku R., Neuroreport. October 16, 2019; 30 (15): 998-1003.
The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. , Silbernagel N., FASEB J. November 1, 2018; 32 (11): 6159-6173.
Hydrophobic alkyl chains substituted to the 8-position of cyclic nucleotides enhance activation of CNG and HCN channels by an intricate enthalpy - entropy compensation. , Otte M., Sci Rep. October 8, 2018; 8 (1): 14960.
All four subunits of HCN2 channels contribute to the activation gating in an additive but intricate manner. , Sunkara MR., J Gen Physiol. September 3, 2018; 150 (9): 1261-1271.
Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family. , Alvarez-Baron CP., J Gen Physiol. August 6, 2018; 150 (8): 1203-1213.
Booting up the organism during development: Pre-behavioral functions of the vertebrate brain in guiding body morphogenesis. , Herrera-Rincon C., Commun Integr Biol. February 15, 2018; 11 (1): e1433440.
HCN4 ion channel function is required for early events that regulate anatomical left- right patterning in a nodal and lefty asymmetric gene expression-independent manner. , Pai VP ., Biol Open. October 15, 2017; 6 (10): 1445-1457.
The brain is required for normal muscle and nerve patterning during early Xenopus development. , Herrera-Rincon C., Nat Commun. September 25, 2017; 8 (1): 587.
Gabapentin Modulates HCN4 Channel Voltage-Dependence. , Tae HS., Front Pharmacol. May 26, 2017; 8 554.
Patch-clamp fluorometry-based channel counting to determine HCN channel conductance. , Liu C., J Gen Physiol. July 1, 2016; 148 (1): 65-76.
An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities. , Wemhöner K., Front Mol Neurosci. November 3, 2015; 8 63.
HCN2 channels: a permanent open state and conductance changes. , Pittoors F., J Membr Biol. February 1, 2015; 248 (1): 67-81.
cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore. , Lyashchenko AK., PLoS One. July 1, 2014; 9 (7): e101236.
Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP. , Hu L., J Gen Physiol. December 1, 2013; 142 (6): 599-612.
Flavonoid regulation of EAG1 channels. , Carlson AE., J Gen Physiol. March 1, 2013; 141 (3): 347-58.
Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel. , Wu S ., J Gen Physiol. July 1, 2012; 140 (1): 29-39.
Asymmetric divergence in structure and function of HCN channel duplicates in Ciona intestinalis. , Jackson HA., PLoS One. January 1, 2012; 7 (11): e47590.
Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels. , Vemana S., Am J Physiol Cell Physiol. August 1, 2008; 295 (2): C557-65.
Ion binding in the open HCN pacemaker channel pore: fast mechanisms to shape "slow" channels. , Lyashchenko AK., J Gen Physiol. March 1, 2008; 131 (3): 227-43.
Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels. , Chen S., J Gen Physiol. February 1, 2007; 129 (2): 175-88.
Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2. , Pian P., J Gen Physiol. November 1, 2006; 128 (5): 593-604.
Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels. , Elinder F., J Physiol. September 1, 2006; 575 (Pt 2): 417-31.
Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels. , Craven KB., J Gen Physiol. December 1, 2004; 124 (6): 663-77.
KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents. , Decher N., Pflugers Arch. September 1, 2003; 446 (6): 633-40.
Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions. , Wang J ., J Gen Physiol. September 1, 2001; 118 (3): 237-50.
Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. , Chen S., J Gen Physiol. May 1, 2001; 117 (5): 491-504.