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The diverse effects of pathogenic point mutations on ion channel activity of a gain-of-function polycystin-2. , Wang Y., J Biol Chem. May 1, 2023; 299 (5): 104674.
Regulation of PKD2 channel function by TACAN. , Liu X., J Physiol. January 1, 2023; 601 (1): 83-98.
A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts. , Grosch M., J Cell Sci. August 15, 2021; 134 (16):
Trpc1 as the Missing Link Between the Bmp and Ca2+ Signalling Pathways During Neural Specification in Amphibians. , Néant I ., Sci Rep. November 5, 2019; 9 (1): 16049.
Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels. , Zheng W., Nat Commun. June 13, 2018; 9 (1): 2302.
An Early Function of Polycystin-2 for Left- Right Organizer Induction in Xenopus. , Vick P ., iScience. April 27, 2018; 2 76-85.
Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney. , Zhang B., Development. March 22, 2018; 145 (6):
Hereditary Renal Hypouricemia Type 1 and Autosomal Dominant Polycystic Kidney Disease. , Stiburkova B., Am J Med Sci. October 1, 2015; 350 (4): 268-71.
TRPP2-dependent Ca2+ signaling in dorso- lateral mesoderm is required for kidney field establishment in Xenopus. , Futel M., J Cell Sci. March 1, 2015; 128 (5): 888-99.
Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1. , Woodward OM., PLoS One. August 23, 2010; 5 (8): e12305.
Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease. , Li Y., J Biol Chem. December 25, 2009; 284 (52): 36431-36441.
TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum. , Wegierski T., EMBO J. March 4, 2009; 28 (5): 490-9.
Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. , Bisgrove BW., Dev Biol. November 15, 2005; 287 (2): 274-88.
Localization and loss-of-function implicates ciliary proteins in early, cytoplasmic roles in left- right asymmetry. , Qiu D., Dev Dyn. September 1, 2005; 234 (1): 176-89.
Xenopus TRPN1 ( NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner- ear hair cells. , Shin JB., Proc Natl Acad Sci U S A. August 30, 2005; 102 (35): 12572-7.
Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl channel activity in Xenopus oocytes. , Chernova MN., Kidney Int. August 1, 2005; 68 (2): 632-41.
Evolutionary conservation of Drosophila polycystin-2 as a calcium-activated cation channel. , Venglarik CJ., J Am Soc Nephrol. May 1, 2004; 15 (5): 1168-77.
Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. , Luo Y., Mol Cell Biol. April 1, 2003; 23 (7): 2600-7.
Polycystin-2 interacts with troponin I, an angiogenesis inhibitor. , Li Q ., Biochemistry. January 21, 2003; 42 (2): 450-7.
Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: mutational and functional analysis. , Vandorpe DH., Physiol Genomics. February 28, 2002; 8 (2): 87-98.
Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X. , Chen XZ., Biochem Biophys Res Commun. April 20, 2001; 282 (5): 1251-6.
Differences between the catalytic properties of recombinant human PC2 and endogenous rat PC2. , Bailyes EM., Biochem J. July 15, 1995; 309 ( Pt 2) 587-94.