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A human Mad protein acting as a BMP-regulated transcriptional activator. , Liu F., Nature. June 13, 1996; 381 (6583): 620-3.
Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor. , Thomsen GH ., Development. August 1, 1996; 122 (8): 2359-66.
The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function. , Zhang Y ., Curr Biol. April 1, 1997; 7 (4): 270-6.
Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1. , Wilson PA ., Development. August 1, 1997; 124 (16): 3177-84.
Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. , Candia AF ., Development. November 1, 1997; 124 (22): 4467-80.
The homeobox gene PV.1 mediates specification of the prospective neural ectoderm in Xenopus embryos. , Ault KT., Dev Biol. December 1, 1997; 192 (1): 162-71.
Smad6 inhibits BMP/ Smad1 signaling by specifically competing with the Smad4 tumor suppressor. , Hata A., Genes Dev. January 15, 1998; 12 (2): 186-97.
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. , Shibuya H ., EMBO J. February 16, 1998; 17 (4): 1019-28.
Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning. , Nakayama T ., Development. March 1, 1998; 125 (5): 857-67.
Smad6 functions as an intracellular antagonist of some TGF-beta family members during Xenopus embryogenesis. , Nakayama T ., Genes Cells. June 1, 1998; 3 (6): 387-94.
Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes. , Nguyen VH., Dev Biol. July 1, 1998; 199 (1): 93-110.
Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors. , Souchelnytskyi S., J Biol Chem. September 25, 1998; 273 (39): 25364-70.
Mitogen-activated protein kinase and neural specification in Xenopus. , Uzgare AR., Proc Natl Acad Sci U S A. December 8, 1998; 95 (25): 14833-8.
A molecular basis for Smad specificity. , Lagna G., Dev Dyn. March 1, 1999; 214 (3): 269-77.
Identification of two Smad4 proteins in Xenopus. Their common and distinct properties. , Masuyama N., J Biol Chem. April 23, 1999; 274 (17): 12163-70.
Functional analysis of human Smad1: role of the amino-terminal domain. , Xu RH., Biochem Biophys Res Commun. May 10, 1999; 258 (2): 366-73.
Mouse smad8 phosphorylation downstream of BMP receptors ALK-2, ALK-3, and ALK-6 induces its association with Smad4 and transcriptional activity. , Kawai S., Biochem Biophys Res Commun. May 19, 2000; 271 (3): 682-7.
Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development. , Faure S ., Development. July 1, 2000; 127 (13): 2917-31.
Smad1 and Smad4 are components of the bone morphogenetic protein-4 ( BMP-4)-induced transcription complex of the Xvent-2B promoter. , Henningfeld KA ., J Biol Chem. July 21, 2000; 275 (29): 21827-35.
The bone morphogenetic protein 2 signaling mediator Smad1 participates predominantly in osteogenic and not in chondrogenic differentiation in mesenchymal progenitors C3H10T1/2. , Ju W., J Bone Miner Res. October 1, 2000; 15 (10): 1889-99.
Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. , Wang W., Proc Natl Acad Sci U S A. December 19, 2000; 97 (26): 14394-9.
Calmodulin differentially modulates Smad1 and Smad2 signaling. , Scherer A., J Biol Chem. December 29, 2000; 275 (52): 41430-8.
Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. , Zhang Y , Zhang Y ., Proc Natl Acad Sci U S A. January 30, 2001; 98 (3): 974-9.
Suppression of head formation by Xmsx-1 through the inhibition of intracellular nodal signaling. , Yamamoto TS ., Development. July 1, 2001; 128 (14): 2769-79.
Regulation of the mRNAs encoding proteins of the BMP signaling pathway during the maternal stages of Xenopus development. , Fritz BR., Dev Biol. August 1, 2001; 236 (1): 230-43.
Regulation of MAP kinase by the BMP-4/ TAK1 pathway in Xenopus ectoderm. , Goswami M., Dev Biol. August 15, 2001; 236 (2): 259-70.
Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. , Tremblay KD., Development. September 1, 2001; 128 (18): 3609-21.
Autoregulation of Xvent-2B; direct interaction and functional cooperation of Xvent-2 and Smad1. , Henningfeld KA ., J Biol Chem. January 18, 2002; 277 (3): 2097-103.
Endogenous patterns of BMP signaling during early chick development. , Faure S ., Dev Biol. April 1, 2002; 244 (1): 44-65.
Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger ( OAZ). , Shim S ., Nucleic Acids Res. July 15, 2002; 30 (14): 3107-17.
A component of the ARC/Mediator complex required for TGF beta/ Nodal signalling. , Kato Y ., Nature. August 8, 2002; 418 (6898): 641-6.
Negative regulation of BMP signaling by the ski oncoprotein. , Luo K., J Bone Joint Surg Am. January 1, 2003; 85-A Suppl 3 39-43.
SANE, a novel LEM domain protein, regulates bone morphogenetic protein signaling through interaction with Smad1. , Raju GP., J Biol Chem. January 3, 2003; 278 (1): 428-37.
XMAN1, an inner nuclear membrane protein, antagonizes BMP signaling by interacting with Smad1 in Xenopus embryos. , Osada S., Development. May 1, 2003; 130 (9): 1783-94.
Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. , Murakami G., Mol Biol Cell. July 1, 2003; 14 (7): 2809-17.
[The role of Smads and related transcription factors in the signal transduction of bone morphogenetic protein inducing bone formation]. , Xu XL., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. September 1, 2003; 17 (5): 359-62.
Dorsal- ventral patterning and neural induction in Xenopus embryos. , De Robertis EM ., Annu Rev Cell Dev Biol. January 1, 2004; 20 285-308.
Interaction with Smad4 is indispensable for suppression of BMP signaling by c- Ski. , Takeda M., Mol Biol Cell. March 1, 2004; 15 (3): 963-72.
A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways. , Zuzarte-Luís V., Dev Biol. August 1, 2004; 272 (1): 39-52.
The POU factor Oct-25 regulates the Xvent-2B gene and counteracts terminal differentiation in Xenopus embryos. , Cao Y , Cao Y ., J Biol Chem. October 15, 2004; 279 (42): 43735-43.
MAB21L2, a vertebrate member of the Male-abnormal 21 family, modulates BMP signaling and interacts with SMAD1. , Baldessari D., BMC Cell Biol. December 21, 2004; 5 (1): 48.
Conditional BMP inhibition in Xenopus reveals stage-specific roles for BMPs in neural and neural crest induction. , Wawersik S., Dev Biol. January 15, 2005; 277 (2): 425-42.
Kielin/ chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. , Lin J., Nat Med. April 1, 2005; 11 (4): 387-93.
DRAGON, a bone morphogenetic protein co-receptor. , Samad TA., J Biol Chem. April 8, 2005; 280 (14): 14122-9.
Smad1 and Smad8 function similarly in mammalian central nervous system development. , Hester M., Mol Cell Biol. June 1, 2005; 25 (11): 4683-92.
Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. , Alliston T., J Biol Chem. June 24, 2005; 280 (25): 24227-37.
An Oct-1 binding site mediates activation of the gata2 promoter by BMP signaling. , Oren T., Nucleic Acids Res. August 1, 2005; 33 (13): 4357-67.
Eye and neural defects associated with loss of GDF6. , Hanel ML., BMC Dev Biol. June 6, 2006; 6 43.
Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling. , Knockaert M., Proc Natl Acad Sci U S A. August 8, 2006; 103 (32): 11940-5.
Schnurri transcription factors from Drosophila and vertebrates can mediate Bmp signaling through a phylogenetically conserved mechanism. , Yao LC., Development. October 1, 2006; 133 (20): 4025-34.