XB-LAB-597
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The Good Lab
Research Interests
Cell Biology of Genome Activation and Membraneless Organelles, Engineered Living SystemsResearch Area
We are interested in the unique cell biology of early embryo development. We study how the zygotic genome awakens and the assembly of membraneless organelles. We are also interested in how cells regulate their dimensions. Our interdisciplinary team leverages tools and models from cell biology, chemistry, synthetic biology and development. We study how proteins self-organize into sub-compartments inside the cell and engineer these organelles to control cell signaling and information processing. We are interested in mechanisms regulating the onset of genome activation in blastula stage embryos, as part of the maternal-zygotic transition. We investigate how embryos make decisions in early development. Additionally we study how collections of cells self-organize and pattern the cleavage stage embryo. We study how cell and organelle sizes are regulated and how dysregulation of scaling relationships contribute to disease. We leverage the early embryo which undergoes cell division in the absence of cell growth. We build synthetic cell-like systems and organelles as biomimetic platforms and for deliveryCurrent Members
Good, Matthew C
(Principal Investigator/Director)
Alumni
Chen, Hui
(Post-doc)
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