Florian Lesage - Publications

Publications (41)

XB-PERS-2691

Publications By Florian Lesage

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Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK., Royal P, Andres-Bilbe A, Ávalos Prado P, Verkest C, Wdziekonski B, Schaub S, Baron A, Lesage F, Gasull X, Levitz J, Sandoz G., Neuron. January 16, 2019; 101 (2): 232-245.e6.
The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size., Christensen AH, Chatelain FC, Huttner IG, Olesen MS, Soka M, Feliciangeli S, Horvat C, Santiago CF, Vandenberg JI, Schmitt N, Olesen SP, Lesage F, Fatkin D., J Mol Cell Cardiol. August 1, 2016; 97 24-35.
Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels., Blin S, Chatelain FC, Feliciangeli S, Kang D, Lesage F, Bichet D., J Biol Chem. October 10, 2014; 289 (41): 28202-12.
Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel., Rodrigues N, Bennis K, Vivier D, Pereira V, C Chatelain F, Chapuy E, Deokar H, Busserolles J, Lesage F, Eschalier A, Ducki S., Eur J Med Chem. March 21, 2014; 75 391-402.
Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane., Chatelain FC, Bichet D, Feliciangeli S, Larroque MM, Braud VM, Douguet D, Lesage F., J Biol Chem. December 6, 2013; 288 (49): 35081-92.
TWIK1, a unique background channel with variable ion selectivity., Chatelain FC, Bichet D, Douguet D, Feliciangeli S, Bendahhou S, Reichold M, Warth R, Barhanin J, Lesage F., Proc Natl Acad Sci U S A. April 3, 2012; 109 (14): 5499-504.
Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue., Sandoz G, Douguet D, Chatelain F, Lazdunski M, Lesage F., Proc Natl Acad Sci U S A. August 25, 2009; 106 (34): 14628-33.
Mtap2 is a constituent of the protein network that regulates twik-related K+ channel expression and trafficking., Sandoz G, Tardy MP, Thümmler S, Feliciangeli S, Lazdunski M, Lesage F., J Neurosci. August 20, 2008; 28 (34): 8545-52.
Does sumoylation control K2P1/TWIK1 background K+ channels?, Feliciangeli S, Bendahhou S, Sandoz G, Gounon P, Reichold M, Warth R, Lazdunski M, Barhanin J, Lesage F., Cell. August 10, 2007; 130 (3): 563-9.
AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels., Sandoz G, Thümmler S, Duprat F, Feliciangeli S, Vinh J, Escoubas P, Guy N, Lazdunski M, Lesage F., EMBO J. December 13, 2006; 25 (24): 5864-72.
Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit., Hibino H, Pironkova R, Onwumere O, Rousset M, Charnet P, Hudspeth AJ, Lesage F., Proc Natl Acad Sci U S A. January 7, 2003; 100 (1): 307-12.
Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels., Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F., Biochem Biophys Res Commun. March 23, 2001; 282 (1): 249-56.
TASK (TWIK-related acid-sensitive K+ channel) is expressed in glomerulosa cells of rat adrenal cortex and inhibited by angiotensin II., Czirják G, Fischer T, Spät A, Lesage F, Enyedi P., Mol Endocrinol. June 1, 2000; 14 (6): 863-74.
TREK-1 is a heat-activated background K(+) channel., Maingret F, Lauritzen I, Patel AJ, Heurteaux C, Reyes R, Lesage F, Lazdunski M, Honoré E., EMBO J. June 1, 2000; 19 (11): 2483-91.
Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure., Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M., J Biol Chem. April 23, 1999; 274 (17): 11751-60.
A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids., Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M., EMBO J. June 15, 1998; 17 (12): 3297-308.
TASK, a human background K+ channel to sense external pH variations near physiological pH., Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M., EMBO J. September 1, 1997; 16 (17): 5464-71.
The structure, function and distribution of the mouse TWIK-1 K+ channel., Lesage F, Lauritzen I, Duprat F, Reyes R, Fink M, Heurteaux C, Lazdunski M., FEBS Lett. January 27, 1997; 402 (1): 28-32.
Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel., Fink M, Duprat F, Lesage F, Reyes R, Romey G, Heurteaux C, Lazdunski M., EMBO J. December 16, 1996; 15 (24): 6854-62.
Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge., Lesage F, Reyes R, Fink M, Duprat F, Guillemare E, Lazdunski M., EMBO J. December 2, 1996; 15 (23): 6400-7.
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current., Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M, Romey G., Nature. November 7, 1996; 384 (6604): 78-80.
A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression., Fink M, Duprat F, Lesage F, Heurteaux C, Romey G, Barhanin J, Lazdunski M., J Biol Chem. October 18, 1996; 271 (42): 26341-8.
Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels., Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattéi MG, Lazdunski M., EMBO J. July 1, 1996; 15 (13): 3322-31.
TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure., Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J., EMBO J. March 1, 1996; 15 (5): 1004-11.
A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties., Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J., J Biol Chem. February 23, 1996; 271 (8): 4183-7.
Dominant negative chimeras provide evidence for homo and heteromultimeric assembly of inward rectifier K+ channel proteins via their N-terminal end., Fink M, Duprat F, Heurteaux C, Lesage F, Romey G, Barhanin J, Lazdunski M., FEBS Lett. January 2, 1996; 378 (1): 64-8.
Susceptibility of cloned K+ channels to reactive oxygen species., Duprat F, Guillemare E, Romey G, Fink M, Lesage F, Lazdunski M, Honore E., Proc Natl Acad Sci U S A. December 5, 1995; 92 (25): 11796-800.
Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels., Lesage F, Guillemare E, Fink M, Duprat F, Heurteaux C, Fosset M, Romey G, Barhanin J, Lazdunski M., J Biol Chem. December 1, 1995; 270 (48): 28660-7.
Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers., Duprat F, Lesage F, Guillemare E, Fink M, Hugnot JP, Bigay J, Lazdunski M, Romey G, Barhanin J., Biochem Biophys Res Commun. July 17, 1995; 212 (2): 657-63.
Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain., Lesage F, Duprat F, Fink M, Guillemare E, Coppola T, Lazdunski M, Hugnot JP., FEBS Lett. October 10, 1994; 353 (1): 37-42.
Injection of a K+ channel (Kv1.3) cRNA in fertilized eggs leads to functional expression in cultured myotomal muscle cells from Xenopus embryos., Honoré E, Guillemare E, Lesage F, Barhanin J, Lazdunski M., FEBS Lett. July 18, 1994; 348 (3): 259-62.
Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel., Attali B, Lesage F, Ziliani P, Guillemare E, Honoré E, Waldmann R, Hugnot JP, Mattéi MG, Lazdunski M, Barhanin J., J Biol Chem. November 15, 1993; 268 (32): 24283-9.
The protein IsK is a dual activator of K+ and Cl- channels., Attali B, Guillemare E, Lesage F, Honoré E, Romey G, Lazdunski M, Barhanin J., Nature. October 28, 1993; 365 (6449): 850-2.
Are Xenopus oocytes unique in displaying functional IsK channel heterologous expression?, Lesage F, Attali B, Lakey J, Honoré E, Romey G, Faurobert E, Lazdunski M, Barhanin J., Recept Channels. January 1, 1993; 1 (2): 143-52.
Effects of the level of mRNA expression on biophysical properties, sensitivity to neurotoxins, and regulation of the brain delayed-rectifier K+ channels Kv1.2., Guillemare E, Honoré E, Pradier L, Lesage F, Schweitz H, Attali B, Barhanin J, Lazdunski M., Biochemistry. December 15, 1992; 31 (49): 12463-8.
Different types of K+ channel current are generated by different levels of a single mRNA., Honoré E, Attali B, Romey G, Lesage F, Barhanin J, Lazdunski M., EMBO J. July 1, 1992; 11 (7): 2465-71.
Regulation of a major cloned voltage-gated K+ channel from human T lymphocytes., Attali B, Honoré E, Lesage F, Lazdunski M, Barhanin J., FEBS Lett. June 1, 1992; 303 (2-3): 229-32.
Receptor-mediated regulation of IsK, a very slowly activating, voltage-dependent K+ channel in Xenopus oocytes., Honore E, Attali B, Lesage F, Barhanin J, Lazdunski M., Biochem Biophys Res Commun. May 15, 1992; 184 (3): 1135-41.
Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes., Attali B, Romey G, Honoré E, Schmid-Alliana A, Mattéi MG, Lesage F, Ricard P, Barhanin J, Lazdunski M., J Biol Chem. April 25, 1992; 267 (12): 8650-7.
ISK, a slowly activating voltage-sensitive K+ channel. Characterization of multiple cDNAs and gene organization in the mouse., Lesage F, Attali B, Lazdunski M, Barhanin J., FEBS Lett. April 20, 1992; 301 (2): 168-72.
Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart., Honoré E, Attali B, Romey G, Heurteaux C, Ricard P, Lesage F, Lazdunski M, Barhanin J., EMBO J. October 1, 1991; 10 (10): 2805-11.

Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK., Royal P, Andres-Bilbe A, Ávalos Prado P, Verkest C, Wdziekonski B, Schaub S, Baron A, Lesage F, Gasull X, Levitz J, Sandoz G., Neuron. January 16, 2019; 101 (2): 232-245.e6.

The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size., Christensen AH, Chatelain FC, Huttner IG, Olesen MS, Soka M, Feliciangeli S, Horvat C, Santiago CF, Vandenberg JI, Schmitt N, Olesen SP, Lesage F, Fatkin D., J Mol Cell Cardiol. August 1, 2016; 97 24-35.

Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels., Blin S, Chatelain FC, Feliciangeli S, Kang D, Lesage F, Bichet D., J Biol Chem. October 10, 2014; 289 (41): 28202-12.

Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel., Rodrigues N, Bennis K, Vivier D, Pereira V, C Chatelain F, Chapuy E, Deokar H, Busserolles J, Lesage F, Eschalier A, Ducki S., Eur J Med Chem. March 21, 2014; 75 391-402.

Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane., Chatelain FC, Bichet D, Feliciangeli S, Larroque MM, Braud VM, Douguet D, Lesage F., J Biol Chem. December 6, 2013; 288 (49): 35081-92.

TWIK1, a unique background channel with variable ion selectivity., Chatelain FC, Bichet D, Douguet D, Feliciangeli S, Bendahhou S, Reichold M, Warth R, Barhanin J, Lesage F., Proc Natl Acad Sci U S A. April 3, 2012; 109 (14): 5499-504.

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue., Sandoz G, Douguet D, Chatelain F, Lazdunski M, Lesage F., Proc Natl Acad Sci U S A. August 25, 2009; 106 (34): 14628-33.

Mtap2 is a constituent of the protein network that regulates twik-related K+ channel expression and trafficking., Sandoz G, Tardy MP, Thümmler S, Feliciangeli S, Lazdunski M, Lesage F., J Neurosci. August 20, 2008; 28 (34): 8545-52.

Does sumoylation control K2P1/TWIK1 background K+ channels?, Feliciangeli S, Bendahhou S, Sandoz G, Gounon P, Reichold M, Warth R, Lazdunski M, Barhanin J, Lesage F., Cell. August 10, 2007; 130 (3): 563-9.

AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels., Sandoz G, Thümmler S, Duprat F, Feliciangeli S, Vinh J, Escoubas P, Guy N, Lazdunski M, Lesage F., EMBO J. December 13, 2006; 25 (24): 5864-72.

Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit., Hibino H, Pironkova R, Onwumere O, Rousset M, Charnet P, Hudspeth AJ, Lesage F., Proc Natl Acad Sci U S A. January 7, 2003; 100 (1): 307-12.

Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels., Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F., Biochem Biophys Res Commun. March 23, 2001; 282 (1): 249-56.

TASK (TWIK-related acid-sensitive K+ channel) is expressed in glomerulosa cells of rat adrenal cortex and inhibited by angiotensin II., Czirják G, Fischer T, Spät A, Lesage F, Enyedi P., Mol Endocrinol. June 1, 2000; 14 (6): 863-74.

TREK-1 is a heat-activated background K(+) channel., Maingret F, Lauritzen I, Patel AJ, Heurteaux C, Reyes R, Lesage F, Lazdunski M, Honoré E., EMBO J. June 1, 2000; 19 (11): 2483-91.

Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure., Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M., J Biol Chem. April 23, 1999; 274 (17): 11751-60.

A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids., Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M., EMBO J. June 15, 1998; 17 (12): 3297-308.

TASK, a human background K+ channel to sense external pH variations near physiological pH., Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M., EMBO J. September 1, 1997; 16 (17): 5464-71.

The structure, function and distribution of the mouse TWIK-1 K+ channel., Lesage F, Lauritzen I, Duprat F, Reyes R, Fink M, Heurteaux C, Lazdunski M., FEBS Lett. January 27, 1997; 402 (1): 28-32.

Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel., Fink M, Duprat F, Lesage F, Reyes R, Romey G, Heurteaux C, Lazdunski M., EMBO J. December 16, 1996; 15 (24): 6854-62.

Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge., Lesage F, Reyes R, Fink M, Duprat F, Guillemare E, Lazdunski M., EMBO J. December 2, 1996; 15 (23): 6400-7.

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current., Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M, Romey G., Nature. November 7, 1996; 384 (6604): 78-80.

A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression., Fink M, Duprat F, Lesage F, Heurteaux C, Romey G, Barhanin J, Lazdunski M., J Biol Chem. October 18, 1996; 271 (42): 26341-8.

Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels., Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattéi MG, Lazdunski M., EMBO J. July 1, 1996; 15 (13): 3322-31.

TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure., Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J., EMBO J. March 1, 1996; 15 (5): 1004-11.

A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties., Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J., J Biol Chem. February 23, 1996; 271 (8): 4183-7.

Dominant negative chimeras provide evidence for homo and heteromultimeric assembly of inward rectifier K+ channel proteins via their N-terminal end., Fink M, Duprat F, Heurteaux C, Lesage F, Romey G, Barhanin J, Lazdunski M., FEBS Lett. January 2, 1996; 378 (1): 64-8.

Susceptibility of cloned K+ channels to reactive oxygen species., Duprat F, Guillemare E, Romey G, Fink M, Lesage F, Lazdunski M, Honore E., Proc Natl Acad Sci U S A. December 5, 1995; 92 (25): 11796-800.

Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels., Lesage F, Guillemare E, Fink M, Duprat F, Heurteaux C, Fosset M, Romey G, Barhanin J, Lazdunski M., J Biol Chem. December 1, 1995; 270 (48): 28660-7.

Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers., Duprat F, Lesage F, Guillemare E, Fink M, Hugnot JP, Bigay J, Lazdunski M, Romey G, Barhanin J., Biochem Biophys Res Commun. July 17, 1995; 212 (2): 657-63.

Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain., Lesage F, Duprat F, Fink M, Guillemare E, Coppola T, Lazdunski M, Hugnot JP., FEBS Lett. October 10, 1994; 353 (1): 37-42.

Injection of a K+ channel (Kv1.3) cRNA in fertilized eggs leads to functional expression in cultured myotomal muscle cells from Xenopus embryos., Honoré E, Guillemare E, Lesage F, Barhanin J, Lazdunski M., FEBS Lett. July 18, 1994; 348 (3): 259-62.

Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel., Attali B, Lesage F, Ziliani P, Guillemare E, Honoré E, Waldmann R, Hugnot JP, Mattéi MG, Lazdunski M, Barhanin J., J Biol Chem. November 15, 1993; 268 (32): 24283-9.

The protein IsK is a dual activator of K+ and Cl- channels., Attali B, Guillemare E, Lesage F, Honoré E, Romey G, Lazdunski M, Barhanin J., Nature. October 28, 1993; 365 (6449): 850-2.

Are Xenopus oocytes unique in displaying functional IsK channel heterologous expression?, Lesage F, Attali B, Lakey J, Honoré E, Romey G, Faurobert E, Lazdunski M, Barhanin J., Recept Channels. January 1, 1993; 1 (2): 143-52.

Effects of the level of mRNA expression on biophysical properties, sensitivity to neurotoxins, and regulation of the brain delayed-rectifier K+ channels Kv1.2., Guillemare E, Honoré E, Pradier L, Lesage F, Schweitz H, Attali B, Barhanin J, Lazdunski M., Biochemistry. December 15, 1992; 31 (49): 12463-8.

Different types of K+ channel current are generated by different levels of a single mRNA., Honoré E, Attali B, Romey G, Lesage F, Barhanin J, Lazdunski M., EMBO J. July 1, 1992; 11 (7): 2465-71.

Regulation of a major cloned voltage-gated K+ channel from human T lymphocytes., Attali B, Honoré E, Lesage F, Lazdunski M, Barhanin J., FEBS Lett. June 1, 1992; 303 (2-3): 229-32.

Receptor-mediated regulation of IsK, a very slowly activating, voltage-dependent K+ channel in Xenopus oocytes., Honore E, Attali B, Lesage F, Barhanin J, Lazdunski M., Biochem Biophys Res Commun. May 15, 1992; 184 (3): 1135-41.

Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes., Attali B, Romey G, Honoré E, Schmid-Alliana A, Mattéi MG, Lesage F, Ricard P, Barhanin J, Lazdunski M., J Biol Chem. April 25, 1992; 267 (12): 8650-7.

ISK, a slowly activating voltage-sensitive K+ channel. Characterization of multiple cDNAs and gene organization in the mouse., Lesage F, Attali B, Lazdunski M, Barhanin J., FEBS Lett. April 20, 1992; 301 (2): 168-72.

Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart., Honoré E, Attali B, Romey G, Heurteaux C, Ricard P, Lesage F, Lazdunski M, Barhanin J., EMBO J. October 1, 1991; 10 (10): 2805-11.

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