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ccl19 and ccl21 affect cell movements and differentiation in early Xenopus development. , Goto T , Michiue T , Shibuya H ., Dev Growth Differ. April 1, 2023; 65 (3): 175-189.
maea affects head formation through ß-catenin degradation during early Xenopus laevis development. , Goto T , Shibuya H ., Dev Growth Differ. January 1, 2023; 65 (1): 29-36.
ccr7 affects both morphogenesis and differentiation during early Xenopus embryogenesis. , Goto T , Michiue T , Shibuya H ., Dev Growth Differ. June 1, 2022; 64 (5): 254-260.
Selective inhibition of the kinase DYRK1A by targeting its folding process. , Kii I, Sumida Y, Goto T , Sonamoto R, Okuno Y, Yoshida S, Kato-Sumida T, Koike Y, Abe M, Nonaka Y, Ikura T, Ito N, Shibuya H , Hosoya T, Hagiwara M., Nat Commun. April 22, 2016; 7 11391.
IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling. , Goto T , Sato A, Adachi S, Iemura S, Natsume T, Shibuya H ., J Biol Chem. December 20, 2013; 288 (51): 36351-60.
WNK4 is an essential effector of anterior formation in FGF signaling. , Shimizu M, Goto T , Sato A, Shibuya H ., Genes Cells. June 1, 2013; 18 (6): 442-9.
IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling. , Goto T , Sato A, Shimizu M, Adachi S, Satoh K, Iemura S, Natsume T, Shibuya H ., PLoS One. January 1, 2013; 8 (4): e60865.
Xenopus furry contributes to release of microRNA gene silencing. , Goto T , Fukui A , Shibuya H , Keller R , Asashima M ., Proc Natl Acad Sci U S A. November 9, 2010; 107 (45): 19344-9.
Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. , Ogawa Y, Nonaka Y, Goto T , Ohnishi E, Hiramatsu T, Kii I, Yoshida M, Ikura T, Onogi H, Shibuya H , Hosoya T, Ito N, Hagiwara M., Nat Commun. October 5, 2010; 1 86.
Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase. , Ohnishi E, Goto T , Sato A, Kim MS , Iemura S, Ishitani T, Natsume T, Ohnishi J, Shibuya H ., Mol Cell Biol. February 1, 2010; 30 (3): 675-83.
TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. , Watanabe Y, Itoh S, Goto T , Ohnishi E, Inamitsu M, Itoh F, Satoh K, Wiercinska E, Yang W, Shi L, Tanaka A, Nakano N, Mommaas AM, Shibuya H , Ten Dijke P, Kato M., Mol Cell. January 15, 2010; 37 (1): 123-34.
Nemo-like kinase- myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development. , Satoh K, Ohnishi J, Sato A, Takeyama M, Iemura S, Natsume T, Shibuya H ., Mol Cell Biol. November 1, 2007; 27 (21): 7623-30.
NARF, an nemo-like kinase ( NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). , Yamada M, Ohnishi J, Ohkawara B, Iemura S, Satoh K, Hyodo-Miura J, Kawachi K, Natsume T, Shibuya H ., J Biol Chem. July 28, 2006; 281 (30): 20749-20760.
Manipulation of alternative splicing by a newly developed inhibitor of Clks. , Muraki M, Ohkawara B, Hosoya T, Onogi H, Koizumi J, Koizumi T, Sumi K, Yomoda J, Murray MV, Kimura H, Furuichi K, Shibuya H , Krainer AR, Suzuki M , Hagiwara M., J Biol Chem. June 4, 2004; 279 (23): 24246-54.
Role of the TAK1- NLK- STAT3 pathway in TGF-beta-mediated mesoderm induction. , Ohkawara B, Shirakabe K, Hyodo-Miura J, Matsuo R, Ueno N , Matsumoto K , Shibuya H ., Genes Dev. February 15, 2004; 18 (4): 381-6.
Negative regulation of Wnt signalling by HMG2L1, a novel NLK-binding protein. , Yamada M, Ohkawara B, Ichimura N, Hyodo-Miura J, Urushiyama S, Shirakabe K, Shibuya H ., Genes Cells. August 1, 2003; 8 (8): 677-84.
The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/ JNK signalling pathway. , Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H , Takada S, Minami Y., Genes Cells. July 1, 2003; 8 (7): 645-54.
Involvement of NLK and Sox11 in neural induction in Xenopus development. , Hyodo-Miura J, Urushiyama S, Nagai S, Nishita M, Ueno N , Shibuya H ., Genes Cells. May 1, 2002; 7 (5): 487-96.
BIP, a BRAM-interacting protein involved in TGF-beta signalling, regulates body length in Caenorhabditis elegans. , Sugawara K, Morita K, Ueno N , Shibuya H ., Genes Cells. July 1, 2001; 6 (7): 599-606.
Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. , Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H , Akiyama T., Genes Dev. July 15, 2000; 14 (14): 1741-9.
The TGF-beta family member derrière is involved in regulation of the establishment of left- right asymmetry. , Hanafusa H , Masuyama N, Kusakabe M , Shibuya H , Nishida E ., EMBO Rep. July 1, 2000; 1 (1): 32-9.
Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer. , Nishita M, Hashimoto MK, Ogata S, Laurent MN, Ueno N , Shibuya H , Cho KW ., Nature. February 17, 2000; 403 (6771): 781-5.
The TAK1- NLK- MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. , Ishitani T, Ninomiya-Tsuji J, Nagai S, Nishita M, Meneghini M, Barker N, Waterman M, Bowerman B, Clevers H, Shibuya H , Matsumoto K ., Nature. June 24, 1999; 399 (6738): 798-802.
Identification of two Smad4 proteins in Xenopus. Their common and distinct properties. , Masuyama N, Hanafusa H , Kusakabe M , Shibuya H , Nishida E ., J Biol Chem. April 23, 1999; 274 (17): 12163-70.
A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction. , Miyama K, Yamada G, Yamamoto TS , Takagi C, Miyado K, Sakai M, Ueno N , Shibuya H ., Dev Biol. April 1, 1999; 208 (1): 123-33.
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1- TAK1 in the BMP signaling pathway. , Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N , Nishida E , Shibuya H , Matsumoto K ., EMBO J. January 4, 1999; 18 (1): 179-87.
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. , Shibuya H , Iwata H, Masuyama N, Gotoh Y, Yamaguchi K, Irie K, Matsumoto K , Nishida E , Ueno N ., EMBO J. February 16, 1998; 17 (4): 1019-28.