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Allosteric Activation of α7 Nicotinic Acetylcholine Receptors by Novel 2-Arylamino-thiazole-5-carboxylic Acid Amide Derivatives for the Improvement of Cognitive Deficits in Mice. , Yang C, Meng Y, Wang X , Li X, Yu T, Liao W, Xie W, Jiang Q, Wang H, Shi C, Jiao W, Bian X, Hu F, Wang X , Liu Y , Zhang L, Wang K, Sun Q., J Med Chem. April 25, 2024; 67 (8): 6344-6364.
Integrative analysis confirms TPX2 as a novel biomarker for clinical implication, tumor microenvironment, and immunotherapy response across human solid tumors. , Zhu M, Wang X , Zhang Q , Xie C, Wang T, Shen K, Zhang L, Zhou X ., Aging (Albany NY). February 2, 2024; 16 (3): 2563-2590.
Response of Odorant Receptors with Phenylacetaldehyde and the Effects on the Behavior of the Rice Water Weevil (Lissorhoptrus oryzophilus). , Zhang X, Wang X , Zhao S, Fang K, Wang Z, Liu J , Xi J, Wang S, Zhang J., J Agric Food Chem. May 3, 2023; 71 (17): 6541-6551.
mRNA 3' -UTR-mediate translational control through PAS and CPE in sheep oocyte. , Song CR, Zhang RJ, Xue FR, Zhang XJ, Wang XY , Sun D, Ding K, Yang Q, Wang XY , Liang CG., Theriogenology. April 15, 2023; 201 30-40.
Bile acids regulate the epithelial Na+ channel in native tissues through direct binding at multiple sites. , Wang XP , Tomilin V, Nickerson AJ, Tian R, Ertem M, McKernan A, Lei X, Pochynyuk O, Kashlan OB., J Physiol. November 1, 2022; 600 (21): 4695-4711.
Transcriptome characterization and SSR discovery in the giant spiny frog Quasipaa spinosa. , Wang X , Xie Y, Hu W , Wei Z, Wei X, Yuan H, Yao H, Dunxue C., Gene. October 30, 2022; 842 146793.
Cell landscape of larval and adult Xenopus laevis at single-cell resolution. , Liao Y, Ma L, Guo Q, E W, Fang X, Yang L, Ruan F, Wang J , Zhang P, Sun Z, Chen H , Lin Z, Wang X , Wang X , Sun H, Fang X, Zhou Y, Chen M, Shen W, Guo G, Han X., Nat Commun. July 25, 2022; 13 (1): 4306.
An odorant receptor of the green mirid bug, Apolygus lucorum, tuned to linalool. , Zhang S, Wang X , Wang G, Liu F, Liu Y ., Insect Biochem Mol Biol. May 1, 2022; 144 103764.
Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution. , Wang X , Hu W , Li X, Huang D, Li Q , Chan H, Zeng J, Xie C, Chen H , Liu X, Gin T, Wang MH, Cheng ASL, Kang W, To KF, Plewczynski D, Zhang Q , Chen X, Chan DCW, Ko H, Wong SH, Yu J, Chan MTV, Zhang L, Wu WKK., Cancer Res. April 15, 2022; 82 (8): 1482-1491.
Bisphenol A induces apoptosis in response to DNA damage through c-Abl/YAPY357/ p73 pathway in P19 embryonal carcinoma stem cells. , Ren F, Ning H, Ge Y, Yin Z, Chen L, Hu D, Shen S, Wang X , Wang S, Li R, He J., Toxicology. March 30, 2022; 470 153138.
Activation by cleavage of the epithelial Na+ channel α and γ subunits independently coevolved with the vertebrate terrestrial migration. , Wang XP , Balchak DM, Gentilcore C, Clark NL, Kashlan OB., Elife. January 5, 2022; 11
Synthesis and Biological Evaluation of Novel Triazine Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors. , Wang X , Xiao H, Wang J , Huang Z , Peng G, Xie W, Bian X, Liu H , Shi C, Yang T, Li X, Gao J, Meng Y, Jiang Q, Chen W, Hu F, Wei N, Wang X , Zhang L, Wang K, Sun Q., J Med Chem. August 26, 2021; 64 (16): 12379-12396.
Bisphenol A exposure induces apoptosis and impairs early embryonic development in Xenopus laevis. , Ge Y, Ren F, Chen L, Hu D, Wang X , Cui Y, Suo Y, Zhang H , He J, Yin Z, Ning H., Environ Pollut. July 1, 2021; 280 116901.
Heterologous Expression and Functional Analysis of Aedes aegypti Odorant Receptors to Human Odors in Xenopus Oocytes. , Wang X , Chen Z, Wang Y, Liu F, Jiang S, Liu N., J Vis Exp. June 8, 2021; (172):
A plasma membrane transporter coordinates phosphate reallocation and grain filling in cereals. , Ma B, Zhang L, Gao Q, Wang J , Li X, Wang H, Liu Y , Lin H, Liu J , Wang X , Li Q , Deng Y, Tang W, Luan S, He Z., Nat Genet. June 1, 2021; 53 (6): 906-915.
Phosphoproteomic Analysis of X enopus laevis Reveals Expression and Phosphorylation of Hypoxia-Inducible PFKFB3 during Dehydration. , Hawkins LJ , Wang X , Xue X, Wang H, Storey KB ., iScience. October 23, 2020; 23 (10): 101598.
Multiple acid-base and electrolyte disturbances upregulate NBCn1, NBCn2, IRBIT and L- IRBIT in the mTAL. , Wang JL , Wang XY , Wang DK, Parker MD , Musa-Aziz R, Popple J, Guo YM, Min TX, Xia T, Tan M, Liu Y , Boron WF, Chen LM., J Physiol. August 1, 2020; 598 (16): 3395-3415.
Three Host Plant Volatiles, Hexanal, Lauric Acid, and Tetradecane, are Detected by an Antenna-Biased Expressed Odorant Receptor 27 in the Dark Black Chafer Holotrichia parallela. , Wang X , Wang S, Yi J, Li Y, Liu J , Wang J , Xi J., J Agric Food Chem. July 15, 2020; 68 (28): 7316-7323.
Tumor-Suppressive MicroRNA-216b Binds to TPX2, Activating the p53 Signaling in Human Cutaneous Squamous Cell Carcinoma. , Feng C, Zhang HL , Zeng A, Bai M, Wang XJ ., Mol Ther Nucleic Acids. June 5, 2020; 20 186-195.
EphA7 is required for otic epithelial homeostasis by modulating Claudin6 in Xenopus. , Wang X , Sun J, Wang Z, Li C, Mao B ., Biochem Biophys Res Commun. May 28, 2020; 526 (2): 375-380.
Paraoxonase 3 functions as a chaperone to decrease functional expression of the epithelial sodium channel. , Shi S, Montalbetti N, Wang X , Rush BM, Marciszyn AL, Baty CJ, Tan RJ, Carattino MD, Kleyman TR., J Biol Chem. April 10, 2020; 295 (15): 4950-4962.
d-Glucuronolactone attenuates para-xylene-induced defects in neuronal development and plasticity in Xenopus tectum in vivo. , Liao Y, Luo Y, Ding N, Gao J, Wang X , Shen W., Toxicology. January 30, 2020; 430 152341.
In Situ Hybridization and Immunostaining of Xenopus Brain. , Liu KL , Wang XM , Li ZL, Liu Y , He RQ ., Methods Mol Biol. January 1, 2020; 2047 363-375.
NA3 glycan: a potential therapy for retinal pigment epithelial deficiency. , Chintalapudi SR, Wang X , Wang X , Shi Y , Kocak M, Palamoor M, Davis RN, Hollingsworth TJ, Jablonski MM ., FEBS J. December 1, 2019; 286 (24): 4876-4888.
Natural product incarvillateine aggravates epileptic seizures by inhibiting GABAA currents. , Bian X, Zhang Y , Huang B, Wang X , Wang G, Zhu Y, Liu Y , Liang J, Jia Y, Wang K., Eur J Pharmacol. September 5, 2019; 858 172496.
Chemical conversion of nicotinamide into type I positive allosteric modulator of α7 nAChRs. , Li X, Xie W, Wang X , Huang Z , Bian X, Wang K, Sun Q., Bioorg Med Chem Lett. August 1, 2019; 29 (15): 1928-1933.
Murine epithelial sodium (Na+) channel regulation by biliary factors. , Wang XP , Im SJ, Balchak DM, Montalbetti N, Carattino MD, Ray EC, Kashlan OB., J Biol Chem. June 28, 2019; 294 (26): 10182-10193.
Disruption of an amino acid transporter LHT1 leads to growth inhibition and low yields in rice. , Wang X , Yang G, Shi M, Hao D, Wei Q, Wang Z, Fu S, Su Y, Xia J., BMC Plant Biol. June 20, 2019; 19 (1): 268.
Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model. , Sun LL, Yang TY, Wei NN, Lu W, Jiao WX, Zhou QQ, Miao YZ, Gao Q, Wang XT , Sun Q, Wang K., Acta Pharmacol Sin. June 1, 2019; 40 (6): 737-745.
Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice. , Li Y, Sun L, Yang T, Jiao W, Tang J, Huang X , Huang Z , Meng Y, Luo L, Wang X , Bian X, Zhang F, Wang K, Sun Q., J Med Chem. January 10, 2019; 62 (1): 159-173.
Function and pharmacology of glutamate-gated chloride channel exon 9 splice variants from the diamondback moth Plutella xylostella. , Wang X , O Reilly AO, Williamson MS, Puinean AM, Yang Y , Wu S , Wu Y., Insect Biochem Mol Biol. January 1, 2019; 104 58-64.
Conserved cysteines in the finger domain of the epithelial Na+ channel α and γ subunits are proximal to the dynamic finger-thumb domain interface. , Blobner BM, Wang XP , Kashlan OB., J Biol Chem. March 30, 2018; 293 (13): 4928-4939.
Heterologous formation of neonicotinoid-sensitive nAChRs containing UNC-38 and UNC-29 subunits from Bursaphelenchus xylophilus. , Yu N, Liu Y , Wang X , Li J, Bao H, Liu Z., Pestic Biochem Physiol. November 1, 2017; 143 168-172.
Covalent Modifications of Histone H3K9 Promote Binding of CHD3. , Tencer AH, Cox KL, Di L, Bridgers JB, Lyu J, Wang X , Sims JK, Weaver TM, Allen HF, Zhang Y , Gatchalian J, Darcy MA, Gibson MD, Ikebe J, Li W , Wade PA, Hayes JJ, Strahl BD, Kono H, Poirier MG, Musselman CA, Kutateladze TG., Cell Rep. October 10, 2017; 21 (2): 455-466.
Mutations on M3 helix of Plutella xylostella glutamate-gated chloride channel confer unequal resistance to abamectin by two different mechanisms. , Wang X , Puinean AM, O Reilly AO, Williamson MS, Smelt CLC, Millar NS, Wu Y., Insect Biochem Mol Biol. July 1, 2017; 86 50-57.
The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis. , Gao Q, Zhang J, Wang X , Liu Y , He R , Liu X, Wang F, Feng J, Yang D, Wang Z, Meng A, Yan X., Nat Commun. June 7, 2017; 8 15279.
Novel mutations involving βI-, βIIA-, or βIVB-tubulin isotypes with functional resemblance to βIII-tubulin in breast cancer. , Wang W, Zhang H , Wang X , Patterson J, Winter P, Graham K, Ghosh S, Lee JC , Katsetos CD, Mackey JR, Tuszynski JA, Wong GK, Ludueña RF., Protoplasma. May 1, 2017; 254 (3): 1163-1173.
Two spatially and temporally distinct Ca2+ signals convey Arabidopsis thaliana responses to K+ deficiency. , Behera S, Long Y, Schmitz-Thom I, Wang XP , Zhang C, Li H, Steinhorst L, Manishankar P, Ren XL, Offenborn JN, Wu WH, Kudla J, Wang Y., New Phytol. January 1, 2017; 213 (2): 739-750.
BoALMT1, an Al-Induced Malate Transporter in Cabbage, Enhances Aluminum Tolerance in Arabidopsis thaliana. , Zhang L, Wu XX, Wang J , Qi C, Wang X , Wang G, Li M, Li X, Guo YD., Front Plant Sci. January 1, 2017; 8 2156.
Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway. , Li S, Wang X , Ma QH, Yang WL, Zhang XG, Dawe GS, Xiao ZC., Sci Rep. December 23, 2016; 6 39320.
EphA7 modulates apical constriction of hindbrain neuroepithelium during neurulation in Xenopus. , Wang X , Sun J, Li C, Mao B ., Biochem Biophys Res Commun. October 28, 2016; 479 (4): 759-765.
Synergistic and compensatory effects of two point mutations conferring target-site resistance to fipronil in the insect GABA receptor RDL. , Zhang Y , Meng X, Yang Y , Li H, Wang X , Yang B, Zhang J, Li C, Millar NS, Liu Z., Sci Rep. August 25, 2016; 6 32335.
A three amino acid deletion in the transmembrane domain of the nicotinic acetylcholine receptor α6 subunit confers high-level resistance to spinosad in Plutella xylostella. , Wang J , Wang X , Lansdell SJ, Zhang J, Millar NS, Wu Y., Insect Biochem Mol Biol. April 1, 2016; 71 29-36.
A Comprehensive Analysis of the Phylogeny, Genomic Organization and Expression of Immunoglobulin Light Chain Genes in Alligator sinensis, an Endangered Reptile Species. , Wang X , Cheng G, Lu Y, Zhang C, Wu X, Han H, Zhao Y, Ren L., PLoS One. January 1, 2016; 11 (2): e0147704.
A single-point mutation enhances dual functionality of a scorpion toxin. , Wang X , Gao B, Zhu S., Comp Biochem Physiol C Toxicol Pharmacol. January 1, 2016; 179 72-8.
Reduction in mRNA and protein expression of a nicotinic acetylcholine receptor α8 subunit is associated with resistance to imidacloprid in the brown planthopper, Nilaparvata lugens. , Zhang Y , Wang X , Yang B, Hu Y, Huang L, Bass C, Liu Z., J Neurochem. November 1, 2015; 135 (4): 686-94.
Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics. , Jiang D, Du Y, Nomura Y, Wang X , Wu Y, Zhorov BS, Dong K., Insect Biochem Mol Biol. November 1, 2015; 66 88-95.
Selective actions of Lynx proteins on different nicotinic acetylcholine receptors in the locust, Locusta migratoria manilensis. , Wang X , Bao H, Sun H, Zhang Y , Fang J, Liu Q, Liu Z., J Neurochem. August 1, 2015; 134 (3): 455-62.
Xenopus Claudin-6 is required for embryonic pronephros morphogenesis and terminal differentiation. , Sun J, Wang X , Li C, Mao B ., Biochem Biophys Res Commun. July 3, 2015; 462 (3): 178-83.
Dorsoventral patterning of the Xenopus eye involves differential temporal changes in the response of optic stalk and retinal progenitors to Hh signalling. , Wang X , Lupo G, He R , Barsacchi G, Harris WA , Liu Y ., Neural Dev. March 20, 2015; 10 7.