Sarah H Shafik - Publications

Publications (12)

XB-PERS-4121

Publications By Sarah H Shafik

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The role of SWEET4 proteins in the post-phloem sugar transport pathway of Setaria viridis sink tissues., Chen L, Ganguly DR, Shafik SH, Danila F, Grof CPL, Sharwood RE, Furbank RT., J Exp Bot. May 19, 2023; 74 (10): 2968-2986.
Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT., Shafik SH, Richards SN, Corry B, Martin RE., PLoS Biol. May 4, 2022; 20 (5): e3001616.
Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity., Relitti N, Federico S, Pozzetti L, Butini S, Lamponi S, Taramelli D, D'Alessandro S, Martin RE, Shafik SH, Summers RL, Babij SK, Habluetzel A, Tapanelli S, Caldelari R, Gemma S, Campiani G., Eur J Med Chem. April 5, 2021; 215 113227.
Identifying the major lactate transporter of Toxoplasma gondii tachyzoites., Zeng JM, Hapuarachchi SV, Shafik SH, Martin RE, Kirk K, van Dooren GG, Lehane AM., Sci Rep. March 24, 2021; 11 (1): 6787.
Inferring a complete genotype-phenotype map from a small number of measured phenotypes., Sailer ZR, Shafik SH, Summers RL, Joule A, Patterson-Robert A, Martin RE, Harms MJ., PLoS Comput Biol. September 29, 2020; 16 (9): e1008243.
The natural function of the malaria parasite's chloroquine resistance transporter., Shafik SH, Cobbold SA, Barkat K, Richards SN, Lancaster NS, Llinás M, Hogg SJ, Summers RL, McConville MJ, Martin RE., Nat Commun. August 6, 2020; 11 (1): 3922.
The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens., Hapuarachchi SV, Cobbold SA, Shafik SH, Dennis AS, McConville MJ, Martin RE, Kirk K, Lehane AM., PLoS Pathog. February 8, 2017; 13 (2): e1006180.
Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter., Richards SN, Nash MN, Baker ES, Webster MW, Lehane AM, Shafik SH, Martin RE., PLoS Pathog. July 21, 2016; 12 (7): e1005725.
Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs., van Schalkwyk DA, Nash MN, Shafik SH, Summers RL, Lehane AM, Smith PJ, Martin RE., J Infect Dis. March 1, 2016; 213 (5): 800-10.
Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities., Pulcini S, Staines HM, Lee AH, Shafik SH, Bouyer G, Moore CM, Daley DA, Hoke MJ, Altenhofen LM, Painter HJ, Mu J, Ferguson DJ, Llinás M, Martin RE, Fidock DA, Cooper RA, Krishna S., Sci Rep. September 30, 2015; 5 14552.
A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum., Marchetti RV, Lehane AM, Shafik SH, Winterberg M, Martin RE, Kirk K., Nat Commun. March 31, 2015; 6 6721.
1H-NMR metabolite profiles of different strains of Plasmodium falciparum., Teng R, Lehane AM, Winterberg M, Shafik SH, Summers RL, Martin RE, van Schalkwyk DA, Junankar PR, Kirk K., Biosci Rep. November 21, 2014; 34 (6): e00150.

The role of SWEET4 proteins in the post-phloem sugar transport pathway of Setaria viridis sink tissues., Chen L, Ganguly DR, Shafik SH, Danila F, Grof CPL, Sharwood RE, Furbank RT., J Exp Bot. May 19, 2023; 74 (10): 2968-2986.

Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT., Shafik SH, Richards SN, Corry B, Martin RE., PLoS Biol. May 4, 2022; 20 (5): e3001616.

Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity., Relitti N, Federico S, Pozzetti L, Butini S, Lamponi S, Taramelli D, D'Alessandro S, Martin RE, Shafik SH, Summers RL, Babij SK, Habluetzel A, Tapanelli S, Caldelari R, Gemma S, Campiani G., Eur J Med Chem. April 5, 2021; 215 113227.

Identifying the major lactate transporter of Toxoplasma gondii tachyzoites., Zeng JM, Hapuarachchi SV, Shafik SH, Martin RE, Kirk K, van Dooren GG, Lehane AM., Sci Rep. March 24, 2021; 11 (1): 6787.

Inferring a complete genotype-phenotype map from a small number of measured phenotypes., Sailer ZR, Shafik SH, Summers RL, Joule A, Patterson-Robert A, Martin RE, Harms MJ., PLoS Comput Biol. September 29, 2020; 16 (9): e1008243.

The natural function of the malaria parasite's chloroquine resistance transporter., Shafik SH, Cobbold SA, Barkat K, Richards SN, Lancaster NS, Llinás M, Hogg SJ, Summers RL, McConville MJ, Martin RE., Nat Commun. August 6, 2020; 11 (1): 3922.

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens., Hapuarachchi SV, Cobbold SA, Shafik SH, Dennis AS, McConville MJ, Martin RE, Kirk K, Lehane AM., PLoS Pathog. February 8, 2017; 13 (2): e1006180.

Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter., Richards SN, Nash MN, Baker ES, Webster MW, Lehane AM, Shafik SH, Martin RE., PLoS Pathog. July 21, 2016; 12 (7): e1005725.

Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs., van Schalkwyk DA, Nash MN, Shafik SH, Summers RL, Lehane AM, Smith PJ, Martin RE., J Infect Dis. March 1, 2016; 213 (5): 800-10.

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities., Pulcini S, Staines HM, Lee AH, Shafik SH, Bouyer G, Moore CM, Daley DA, Hoke MJ, Altenhofen LM, Painter HJ, Mu J, Ferguson DJ, Llinás M, Martin RE, Fidock DA, Cooper RA, Krishna S., Sci Rep. September 30, 2015; 5 14552.

A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum., Marchetti RV, Lehane AM, Shafik SH, Winterberg M, Martin RE, Kirk K., Nat Commun. March 31, 2015; 6 6721.

1H-NMR metabolite profiles of different strains of Plasmodium falciparum., Teng R, Lehane AM, Winterberg M, Shafik SH, Summers RL, Martin RE, van Schalkwyk DA, Junankar PR, Kirk K., Biosci Rep. November 21, 2014; 34 (6): e00150.

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