Nicholas C Spitzer - Publications

Publications (73)

XB-PERS-686

Publications By Nicholas C Spitzer

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Postsynaptic receptors regulate presynaptic transmitter stability through transsynaptic bridges., Godavarthi SK, Hiramoto M, Ignatyev Y, Levin JB, Li HQ, Pratelli M, Borchardt J, Czajkowski C, Borodinsky LN, Sweeney L, Cline HT, Spitzer NC., Proc Natl Acad Sci U S A. April 9, 2024; 121 (15): e2318041121.
Mechanism for neurotransmitter-receptor matching., Hammond-Weinberger DR, Wang Y, Glavis-Bloom A, Spitzer NC., Proc Natl Acad Sci U S A. February 25, 2020; 117 (8): 4368-4374.
Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference., Dulcis D, Lippi G, Stark CJ, Do LH, Berg DK, Spitzer NC., Neuron. September 13, 2017; 95 (6): 1319-1333.e5.
Non-cell-autonomous mechanism of activity-dependent neurotransmitter switching., Guemez-Gamboa A, Xu L, Meng D, Spitzer NC., Neuron. June 4, 2014; 82 (5): 1004-16.
Imaging and manipulating calcium transients in developing Xenopus spinal neurons., Spitzer NC, Borodinsky LN, Root CM., Cold Spring Harb Protoc. July 1, 2013; 2013 (7): 653-64.
Reserve pool neuron transmitter respecification: Novel neuroplasticity., Dulcis D, Spitzer NC., Dev Neurobiol. April 1, 2012; 72 (4): 465-74.
Spatial and temporal second messenger codes for growth cone turning., Nicol X, Hong KP, Spitzer NC., Proc Natl Acad Sci U S A. August 16, 2011; 108 (33): 13776-81.
Contexts for dopamine specification by calcium spike activity in the CNS., Velázquez-Ulloa NA, Spitzer NC, Dulcis D., J Neurosci. January 5, 2011; 31 (1): 78-88.
cJun integrates calcium activity and tlx3 expression to regulate neurotransmitter specification., Marek KW, Kurtz LM, Spitzer NC., Nat Neurosci. August 1, 2010; 13 (8): 944-50.
Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior., Demarque M, Spitzer NC., Neuron. July 29, 2010; 67 (2): 321-34.
Target-dependent regulation of neurotransmitter specification and embryonic neuronal calcium spike activity., Xiao Q, Xu L, Spitzer NC., J Neurosci. April 21, 2010; 30 (16): 5792-801.
Spontaneous calcium spike activity in embryonic spinal neurons is regulated by developmental expression of the Na+, K+-ATPase beta3 subunit., Chang LW, Spitzer NC., J Neurosci. June 17, 2009; 29 (24): 7877-85.
Illumination controls differentiation of dopamine neurons regulating behaviour., Dulcis D, Spitzer NC., Nature. November 13, 2008; 456 (7219): 195-201.
Embryonically expressed GABA and glutamate drive electrical activity regulating neurotransmitter specification., Root CM, Velázquez-Ulloa NA, Monsalve GC, Minakova E, Spitzer NC., J Neurosci. April 30, 2008; 28 (18): 4777-84.
Neurite outgrowth and in vivo sensory innervation mediated by a Ca(V)2.2-laminin beta 2 stop signal., Sann SB, Xu L, Nishimune H, Sanes JR, Spitzer NC., J Neurosci. March 5, 2008; 28 (10): 2366-74.
Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction., Borodinsky LN, Spitzer NC., Proc Natl Acad Sci U S A. January 2, 2007; 104 (1): 335-40.
Second messenger pas de deux: the coordinated dance between calcium and cAMP., Borodinsky LN, Spitzer NC., Sci STKE. May 23, 2006; 2006 (336): pe22.
Local calcium transients contribute to disappearance of pFAK, focal complex removal and deadhesion of neuronal growth cones and fibroblasts., Conklin MW, Lin MS, Spitzer NC., Dev Biol. November 1, 2005; 287 (1): 201-12.
Activity-dependent homeostatic specification of transmitter expression in embryonic neurons., Borodinsky LN, Root CM, Cronin JA, Sann SB, Gu X, Spitzer NC., Nature. June 3, 2004; 429 (6991): 523-30.
Calcium transients regulate patterned actin assembly during myofibrillogenesis., Li H, Cook JD, Terry M, Spitzer NC, Ferrari MB., Dev Dyn. February 1, 2004; 229 (2): 231-42.
Dynamic interactions of cyclic AMP transients and spontaneous Ca(2+) spikes., Gorbunova YV, Spitzer NC., Nature. July 4, 2002; 418 (6893): 93-6.
Adaptation in the chemotactic guidance of nerve growth cones., Ming GL, Wong ST, Henley J, Yuan XB, Song HJ, Spitzer NC, Poo MM., Nature. May 23, 2002; 417 (6887): 411-8.
Filopodial calcium transients promote substrate-dependent growth cone turning., Gomez TM, Robles E, Poo M, Spitzer NC., Science. March 9, 2001; 291 (5510): 1983-7.
Differentiation of electrical excitability in motoneurons., Spitzer NC, Vincent A, Lautermilch NJ., Brain Res Bull. November 15, 2000; 53 (5): 547-52.
Specific frequencies of spontaneous Ca2+ transients upregulate GAD 67 transcripts in embryonic spinal neurons., Watt SD, Gu X, Smith RD, Spitzer NC., Mol Cell Neurosci. October 1, 2000; 16 (4): 376-87.
Antisense suppression of potassium channel expression demonstrates its role in maturation of the action potential., Vincent A, Lautermilch NJ, Spitzer NC., J Neurosci. August 15, 2000; 20 (16): 6087-94.
Sustained upregulation in embryonic spinal neurons of a Kv3.1 potassium channel gene encoding a delayed rectifier current., Gurantz D, Lautermilch NJ, Watt SD, Spitzer NC., J Neurobiol. February 15, 2000; 42 (3): 347-56.
Regulation of calcineurin by growth cone calcium waves controls neurite extension., Lautermilch NJ, Spitzer NC., J Neurosci. January 1, 2000; 20 (1): 315-25.
Ca(2+)-permeable AMPA receptors and spontaneous presynaptic transmitter release at developing excitatory spinal synapses., Rohrbough J, Spitzer NC., J Neurosci. October 1, 1999; 19 (19): 8528-41.
Calcium signaling in the developing Xenopus myotome., Ferrari MB, Spitzer NC., Dev Biol. September 15, 1999; 213 (2): 269-82.
In vivo regulation of axon extension and pathfinding by growth-cone calcium transients., Gomez TM, Spitzer NC., Nature. January 28, 1999; 397 (6717): 350-5.
Properties of ectopic neurons induced by Xenopus neurogenin1 misexpression., Olson EC, Schinder AF, Dantzker JL, Marcus EA, Spitzer NC, Harris WA., Mol Cell Neurosci. November 1, 1998; 12 (4-5): 281-99.
Development of electrical excitability in embryonic neurons: mechanisms and roles., Spitzer NC, Ribera AB., J Neurobiol. October 1, 1998; 37 (1): 190-7.
A calcium signaling cascade essential for myosin thick filament assembly in Xenopus myocytes., Ferrari MB, Ribbeck K, Hagler DJ, Spitzer NC., J Cell Biol. June 15, 1998; 141 (6): 1349-56.
AMPA and NMDA receptors expressed by differentiating Xenopus spinal neurons., Gleason EL, Spitzer NC., J Neurophysiol. June 1, 1998; 79 (6): 2986-98.
Purposeful patterns of spontaneous calcium transients in embryonic spinal neurons., Spitzer NC, Gu X., Semin Cell Dev Biol. February 1, 1997; 8 (1): 13-9.
Breaking the code: regulation of neuronal differentiation by spontaneous calcium transients., Gu X, Spitzer NC., Dev Neurosci. January 1, 1997; 19 (1): 33-41.
Spontaneous calcium transients regulate myofibrillogenesis in embryonic Xenopus myocytes., Ferrari MB, Rohrbough J, Spitzer NC., Dev Biol. September 15, 1996; 178 (2): 484-97.
Temporal regulation of Shaker- and Shab-like potassium channel gene expression in single embryonic spinal neurons during K+ current development., Gurantz D, Ribera AB, Spitzer NC., J Neurosci. May 15, 1996; 16 (10): 3287-95.
Regulation of intracellular Cl- levels by Na(+)-dependent Cl- cotransport distinguishes depolarizing from hyperpolarizing GABAA receptor-mediated responses in spinal neurons., Rohrbough J, Spitzer NC., J Neurosci. January 1, 1996; 16 (1): 82-91.
Distinct aspects of neuronal differentiation encoded by frequency of spontaneous Ca2+ transients., Gu X, Spitzer NC., Nature. June 29, 1995; 375 (6534): 784-7.
Convertible modes of inactivation of potassium channels in Xenopus myocytes differentiating in vitro., Ernsberger U, Spitzer NC., J Physiol. April 15, 1995; 484 ( Pt 2) 313-29.
Spontaneous calcium transients regulate neuronal plasticity in developing neurons., Spitzer NC, Olson E, Gu X., J Neurobiol. March 1, 1995; 26 (3): 316-24.
Spontaneous neuronal calcium spikes and waves during early differentiation., Gu X, Olson EC, Spitzer NC., J Neurosci. November 1, 1994; 14 (11 Pt 1): 6325-35.
Development of voltage-dependent and ligand-gated channels in excitable membranes., Spitzer NC., Prog Brain Res. January 1, 1994; 102 169-79.
Low-threshold Ca2+ current and its role in spontaneous elevations of intracellular Ca2+ in developing Xenopus neurons., Gu X, Spitzer NC., J Neurosci. November 1, 1993; 13 (11): 4936-48.
Calcium dependence of differentiation of GABA immunoreactivity in spinal neurons., Spitzer NC, Debaca RC, Allen KA, Holliday J., J Comp Neurol. November 1, 1993; 337 (1): 168-75.
In vivo development of voltage-dependent ionic currents in embryonic Xenopus spinal neurons., Desarmenien MG, Clendening B, Spitzer NC., J Neurosci. June 1, 1993; 13 (6): 2575-81.
Calcium regulates neuronal differentiation both directly and via co-cultured myocytes., Holliday J, Spitzer NC., J Neurobiol. April 1, 1993; 24 (4): 506-14.
Role of calcium and protein kinase C in development of the delayed rectifier potassium current in Xenopus spinal neurons., Desarmenien MG, Spitzer NC., Neuron. November 1, 1991; 7 (5): 797-805.

Postsynaptic receptors regulate presynaptic transmitter stability through transsynaptic bridges., Godavarthi SK, Hiramoto M, Ignatyev Y, Levin JB, Li HQ, Pratelli M, Borchardt J, Czajkowski C, Borodinsky LN, Sweeney L, Cline HT, Spitzer NC., Proc Natl Acad Sci U S A. April 9, 2024; 121 (15): e2318041121.

Mechanism for neurotransmitter-receptor matching., Hammond-Weinberger DR, Wang Y, Glavis-Bloom A, Spitzer NC., Proc Natl Acad Sci U S A. February 25, 2020; 117 (8): 4368-4374.

Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference., Dulcis D, Lippi G, Stark CJ, Do LH, Berg DK, Spitzer NC., Neuron. September 13, 2017; 95 (6): 1319-1333.e5.

Non-cell-autonomous mechanism of activity-dependent neurotransmitter switching., Guemez-Gamboa A, Xu L, Meng D, Spitzer NC., Neuron. June 4, 2014; 82 (5): 1004-16.

Imaging and manipulating calcium transients in developing Xenopus spinal neurons., Spitzer NC, Borodinsky LN, Root CM., Cold Spring Harb Protoc. July 1, 2013; 2013 (7): 653-64.

Reserve pool neuron transmitter respecification: Novel neuroplasticity., Dulcis D, Spitzer NC., Dev Neurobiol. April 1, 2012; 72 (4): 465-74.

Spatial and temporal second messenger codes for growth cone turning., Nicol X, Hong KP, Spitzer NC., Proc Natl Acad Sci U S A. August 16, 2011; 108 (33): 13776-81.

Contexts for dopamine specification by calcium spike activity in the CNS., Velázquez-Ulloa NA, Spitzer NC, Dulcis D., J Neurosci. January 5, 2011; 31 (1): 78-88.

cJun integrates calcium activity and tlx3 expression to regulate neurotransmitter specification., Marek KW, Kurtz LM, Spitzer NC., Nat Neurosci. August 1, 2010; 13 (8): 944-50.

Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior., Demarque M, Spitzer NC., Neuron. July 29, 2010; 67 (2): 321-34.

Target-dependent regulation of neurotransmitter specification and embryonic neuronal calcium spike activity., Xiao Q, Xu L, Spitzer NC., J Neurosci. April 21, 2010; 30 (16): 5792-801.

Spontaneous calcium spike activity in embryonic spinal neurons is regulated by developmental expression of the Na+, K+-ATPase beta3 subunit., Chang LW, Spitzer NC., J Neurosci. June 17, 2009; 29 (24): 7877-85.

Illumination controls differentiation of dopamine neurons regulating behaviour., Dulcis D, Spitzer NC., Nature. November 13, 2008; 456 (7219): 195-201.

Embryonically expressed GABA and glutamate drive electrical activity regulating neurotransmitter specification., Root CM, Velázquez-Ulloa NA, Monsalve GC, Minakova E, Spitzer NC., J Neurosci. April 30, 2008; 28 (18): 4777-84.

Neurite outgrowth and in vivo sensory innervation mediated by a Ca(V)2.2-laminin beta 2 stop signal., Sann SB, Xu L, Nishimune H, Sanes JR, Spitzer NC., J Neurosci. March 5, 2008; 28 (10): 2366-74.

Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction., Borodinsky LN, Spitzer NC., Proc Natl Acad Sci U S A. January 2, 2007; 104 (1): 335-40.

Second messenger pas de deux: the coordinated dance between calcium and cAMP., Borodinsky LN, Spitzer NC., Sci STKE. May 23, 2006; 2006 (336): pe22.

Local calcium transients contribute to disappearance of pFAK, focal complex removal and deadhesion of neuronal growth cones and fibroblasts., Conklin MW, Lin MS, Spitzer NC., Dev Biol. November 1, 2005; 287 (1): 201-12.

Activity-dependent homeostatic specification of transmitter expression in embryonic neurons., Borodinsky LN, Root CM, Cronin JA, Sann SB, Gu X, Spitzer NC., Nature. June 3, 2004; 429 (6991): 523-30.

Calcium transients regulate patterned actin assembly during myofibrillogenesis., Li H, Cook JD, Terry M, Spitzer NC, Ferrari MB., Dev Dyn. February 1, 2004; 229 (2): 231-42.

Dynamic interactions of cyclic AMP transients and spontaneous Ca(2+) spikes., Gorbunova YV, Spitzer NC., Nature. July 4, 2002; 418 (6893): 93-6.

Adaptation in the chemotactic guidance of nerve growth cones., Ming GL, Wong ST, Henley J, Yuan XB, Song HJ, Spitzer NC, Poo MM., Nature. May 23, 2002; 417 (6887): 411-8.

Filopodial calcium transients promote substrate-dependent growth cone turning., Gomez TM, Robles E, Poo M, Spitzer NC., Science. March 9, 2001; 291 (5510): 1983-7.

Differentiation of electrical excitability in motoneurons., Spitzer NC, Vincent A, Lautermilch NJ., Brain Res Bull. November 15, 2000; 53 (5): 547-52.

Specific frequencies of spontaneous Ca2+ transients upregulate GAD 67 transcripts in embryonic spinal neurons., Watt SD, Gu X, Smith RD, Spitzer NC., Mol Cell Neurosci. October 1, 2000; 16 (4): 376-87.

Antisense suppression of potassium channel expression demonstrates its role in maturation of the action potential., Vincent A, Lautermilch NJ, Spitzer NC., J Neurosci. August 15, 2000; 20 (16): 6087-94.

Sustained upregulation in embryonic spinal neurons of a Kv3.1 potassium channel gene encoding a delayed rectifier current., Gurantz D, Lautermilch NJ, Watt SD, Spitzer NC., J Neurobiol. February 15, 2000; 42 (3): 347-56.

Regulation of calcineurin by growth cone calcium waves controls neurite extension., Lautermilch NJ, Spitzer NC., J Neurosci. January 1, 2000; 20 (1): 315-25.

Ca(2+)-permeable AMPA receptors and spontaneous presynaptic transmitter release at developing excitatory spinal synapses., Rohrbough J, Spitzer NC., J Neurosci. October 1, 1999; 19 (19): 8528-41.

Calcium signaling in the developing Xenopus myotome., Ferrari MB, Spitzer NC., Dev Biol. September 15, 1999; 213 (2): 269-82.

In vivo regulation of axon extension and pathfinding by growth-cone calcium transients., Gomez TM, Spitzer NC., Nature. January 28, 1999; 397 (6717): 350-5.

Properties of ectopic neurons induced by Xenopus neurogenin1 misexpression., Olson EC, Schinder AF, Dantzker JL, Marcus EA, Spitzer NC, Harris WA., Mol Cell Neurosci. November 1, 1998; 12 (4-5): 281-99.

Development of electrical excitability in embryonic neurons: mechanisms and roles., Spitzer NC, Ribera AB., J Neurobiol. October 1, 1998; 37 (1): 190-7.

A calcium signaling cascade essential for myosin thick filament assembly in Xenopus myocytes., Ferrari MB, Ribbeck K, Hagler DJ, Spitzer NC., J Cell Biol. June 15, 1998; 141 (6): 1349-56.

AMPA and NMDA receptors expressed by differentiating Xenopus spinal neurons., Gleason EL, Spitzer NC., J Neurophysiol. June 1, 1998; 79 (6): 2986-98.

Purposeful patterns of spontaneous calcium transients in embryonic spinal neurons., Spitzer NC, Gu X., Semin Cell Dev Biol. February 1, 1997; 8 (1): 13-9.

Breaking the code: regulation of neuronal differentiation by spontaneous calcium transients., Gu X, Spitzer NC., Dev Neurosci. January 1, 1997; 19 (1): 33-41.

Spontaneous calcium transients regulate myofibrillogenesis in embryonic Xenopus myocytes., Ferrari MB, Rohrbough J, Spitzer NC., Dev Biol. September 15, 1996; 178 (2): 484-97.

Temporal regulation of Shaker- and Shab-like potassium channel gene expression in single embryonic spinal neurons during K+ current development., Gurantz D, Ribera AB, Spitzer NC., J Neurosci. May 15, 1996; 16 (10): 3287-95.

Regulation of intracellular Cl- levels by Na(+)-dependent Cl- cotransport distinguishes depolarizing from hyperpolarizing GABAA receptor-mediated responses in spinal neurons., Rohrbough J, Spitzer NC., J Neurosci. January 1, 1996; 16 (1): 82-91.

Distinct aspects of neuronal differentiation encoded by frequency of spontaneous Ca2+ transients., Gu X, Spitzer NC., Nature. June 29, 1995; 375 (6534): 784-7.

Convertible modes of inactivation of potassium channels in Xenopus myocytes differentiating in vitro., Ernsberger U, Spitzer NC., J Physiol. April 15, 1995; 484 ( Pt 2) 313-29.

Spontaneous calcium transients regulate neuronal plasticity in developing neurons., Spitzer NC, Olson E, Gu X., J Neurobiol. March 1, 1995; 26 (3): 316-24.

Spontaneous neuronal calcium spikes and waves during early differentiation., Gu X, Olson EC, Spitzer NC., J Neurosci. November 1, 1994; 14 (11 Pt 1): 6325-35.

Development of voltage-dependent and ligand-gated channels in excitable membranes., Spitzer NC., Prog Brain Res. January 1, 1994; 102 169-79.

Low-threshold Ca2+ current and its role in spontaneous elevations of intracellular Ca2+ in developing Xenopus neurons., Gu X, Spitzer NC., J Neurosci. November 1, 1993; 13 (11): 4936-48.

Calcium dependence of differentiation of GABA immunoreactivity in spinal neurons., Spitzer NC, Debaca RC, Allen KA, Holliday J., J Comp Neurol. November 1, 1993; 337 (1): 168-75.

In vivo development of voltage-dependent ionic currents in embryonic Xenopus spinal neurons., Desarmenien MG, Clendening B, Spitzer NC., J Neurosci. June 1, 1993; 13 (6): 2575-81.

Calcium regulates neuronal differentiation both directly and via co-cultured myocytes., Holliday J, Spitzer NC., J Neurobiol. April 1, 1993; 24 (4): 506-14.

Role of calcium and protein kinase C in development of the delayed rectifier potassium current in Xenopus spinal neurons., Desarmenien MG, Spitzer NC., Neuron. November 1, 1991; 7 (5): 797-805.

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