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Profile Publications (91)

Publications By Randall T. Moon

Results 1 - 50 of 91 results

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Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness., Cheng J, Tsuda M, Okolotowicz K, Dwyer M, Bushway PJ, Colas AR, Lancman JJ, Schade D, Perea-Gil I, Bruyneel AAN, Lee J, Vadgama N, Quach J, McKeithan WL, Biechele TL, Wu JC, Moon RT, Si Dong PD, Karakikes I, Cashman JR, Mercola M., Cell Chem Biol. May 20, 2021; 28 (5): 625-635.e5.

Transcription-Based Reporters of Wnt/{beta}-Catenin Signaling., Biechele TL, Adams AM, Moon RT., Cold Spring Harb Protoc. June 1, 2009; 2009 (6): pdb.prot5223.

Requirement of Wnt/beta-catenin signaling in pronephric kidney development., Lyons JP, Miller RK, Zhou X, Weidinger G, Deroo T, Denayer T, Park JI, Ji H, Hong JY, Li A, Moon RT, Jones EA, Vleminckx K, Vize PD, McCrea PD., Mech Dev. January 1, 2009; 126 (3-4): 142-59.        

Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1., Louie SH, Yang XY, Conrad WH, Muster J, Angers S, Moon RT, Cheyette BN., PLoS One. January 1, 2009; 4 (2): e4310.                    

Wnt/beta-catenin signaling has an essential role in the initiation of limb regeneration., Yokoyama H, Ogino H, Stoick-Cooper CL, Grainger RM, Moon RT., Dev Biol. June 1, 2007; 306 (1): 170-8.        

Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling., Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C, Biechele TL, Gingras AC, Zheng N, Maccoss MJ, Angers S, Moon RT., Science. May 18, 2007; 316 (5827): 1043-6.

Small-molecule synergist of the Wnt/beta-catenin signaling pathway., Zhang Q, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg MH, Jian X, Randazzo PA, Schultz PG, Moon RT, Ding S., Proc Natl Acad Sci U S A. May 1, 2007; 104 (18): 7444-8.

WNTS and WNT receptors as therapeutic tools and targets in human disease processes., Chien AJ, Moon RT., Front Biosci. January 1, 2007; 12 448-57.

The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation., Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, MacCoss MJ, Moon RT., Nat Cell Biol. April 1, 2006; 8 (4): 348-57.

Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets., Park JI, Kim SW, Lyons JP, Ji H, Nguyen TT, Cho K, Barton MC, Deroo T, Vleminckx K, Moon RT, McCrea PD., Dev Cell. June 1, 2005; 8 (6): 843-54.            

Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes., Waxman JS, Hocking AM, Stoick CL, Moon RT., Development. December 1, 2004; 131 (23): 5909-21.

Teaching resource. Beta-catenin signaling and axis specification., Moon RT., Sci STKE. June 29, 2004; 2004 (240): tr6.

A PKC wave follows the calcium wave after activation of Xenopus eggs., Larabell CA, Rowning BA, Moon RT., Differentiation. February 1, 2004; 72 (1): 41-7.          

Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos., Sheldahl LC, Slusarski DC, Pandur P, Miller JR, Kühl M, Moon RT., J Cell Biol. May 26, 2003; 161 (4): 769-77.            

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy., Robitaille J, MacDonald ML, Kaykas A, Sheldahl LC, Zeisler J, Dubé MP, Zhang LH, Singaraja RR, Guernsey DL, Zheng B, Siebert LF, Hoskin-Mott A, Trese MT, Pimstone SN, Shastry BS, Moon RT, Hayden MR, Goldberg YP, Samuels ME., Nat Genet. October 1, 2002; 32 (2): 326-30.

The promise and perils of Wnt signaling through beta-catenin., Moon RT, Bowerman B, Boutros M, Perrimon N., Science. May 31, 2002; 296 (5573): 1644-6.

Developmental biology: signalling polarity., Moon RT, Shah K., Nature. May 16, 2002; 417 (6886): 239-40.

Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation., Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT., Dev Cell. April 1, 2002; 2 (4): 449-61.  

The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos., Park M, Moon RT., Nat Cell Biol. January 1, 2002; 4 (1): 20-5.

Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+ signaling., Kühl M, Geis K, Sheldahl LC, Pukrop T, Moon RT, Wedlich D., Mech Dev. August 1, 2001; 106 (1-2): 61-76.

G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway., Liu T, DeCostanzo AJ, Liu X, Wang Hy, Hallagan S, Moon RT, Malbon CC., Science. June 1, 2001; 292 (5522): 1718-22.

Inhibition of Tcf3 binding by I-mfa domain proteins., Snider L, Thirlwell H, Miller JR, Moon RT, Groudine M, Tapscott SJ., Mol Cell Biol. March 1, 2001; 21 (5): 1866-73.

The maternal Xenopus beta-catenin signaling pathway, activated by frizzled homologs, induces goosecoid in a cell non-autonomous manner., Brown JD, Hallagan SE, McGrew LL, Miller JR, Moon RT., Dev Growth Differ. August 1, 2000; 42 (4): 347-57.              

The bHLH class protein pMesogenin1 can specify paraxial mesoderm phenotypes., Yoon JK, Moon RT, Wold B., Dev Biol. June 15, 2000; 222 (2): 376-91.            

Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus., Kühl M, Sheldahl LC, Malbon CC, Moon RT., J Biol Chem. April 28, 2000; 275 (17): 12701-11.            

The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression., Takemaru KI, Moon RT., J Cell Biol. April 17, 2000; 149 (2): 249-54.          

Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP., Taunton J, Rowning BA, Coughlin ML, Wu M, Moon RT, Mitchison TJ, Larabell CA., J Cell Biol. February 7, 2000; 148 (3): 519-30.                  

Expression, crystallization and preliminary X-ray studies of the PDZ domain of Dishevelled protein., Khlebtsova N, Hung LW, Henderson K, Moon R, Earnest T., Acta Crystallogr D Biol Crystallogr. February 1, 2000; 56 (Pt 2): 212-4.

Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function., Liu T, Liu X, Wang Hy, Moon RT, Malbon CC., J Biol Chem. November 19, 1999; 274 (47): 33539-44.

Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus., McGrew LL, Takemaru K, Bates R, Moon RT., Mech Dev. September 1, 1999; 87 (1-2): 21-32.

A role for xGCNF in midbrain-hindbrain patterning in Xenopus laevis., Song K, Takemaru KI, Moon RT., Dev Biol. September 1, 1999; 213 (1): 170-9.            

Maternal and embryonic expression of zebrafish lef1., Dorsky RI, Snyder A, Cretekos CJ, Grunwald DJ, Geisler R, Haffter P, Moon RT, Raible DW., Mech Dev. August 1, 1999; 86 (1-2): 147-50.

Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of dishevelled that is dependent on cortical rotation., Miller JR, Rowning BA, Larabell CA, Yang-Snyder JA, Bates RL, Moon RT., J Cell Biol. July 26, 1999; 146 (2): 427-37.                

Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner., Sheldahl LC, Park M, Malbon CC, Moon RT., Curr Biol. July 1, 1999; 9 (13): 695-8.        

XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development., Brannon M, Brown JD, Bates R, Kimelman D, Moon RT., Development. June 1, 1999; 126 (14): 3159-70.                  

Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A., Seeling JM, Miller JR, Gil R, Moon RT, White R, Virshup DM., Science. March 26, 1999; 283 (5410): 2089-91.

Membrane-tethered Drosophila Armadillo cannot transduce Wingless signal on its own., Cox RT, Pai LM, Miller JR, Orsulic S, Stein J, McCormick CA, Audeh Y, Wang W, Moon RT, Peifer M., Development. March 1, 1999; 126 (6): 1327-35.

Regulation of ribosomal S6 protein kinase-p90(rsk), glycogen synthase kinase 3, and beta-catenin in early Xenopus development., Torres MA, Eldar-Finkelman H, Krebs EG, Moon RT., Mol Cell Biol. February 1, 1999; 19 (2): 1427-37.

Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways., Axelrod JD, Miller JR, Shulman JM, Moon RT, Perrimon N., Genes Dev. August 15, 1998; 12 (16): 2610-22.    

From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus., Moon RT, Kimelman D., Bioessays. July 1, 1998; 20 (7): 536-45.

BMP-2/-4 and Wnt-8 cooperatively pattern the Xenopus mesoderm., Hoppler S, Moon RT., Mech Dev. February 1, 1998; 71 (1-2): 119-29.

Wnt and FGF pathways cooperatively pattern anteroposterior neural ectoderm in Xenopus., McGrew LL, Hoppler S, Moon RT., Mech Dev. December 1, 1997; 69 (1-2): 105-14.          

Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling., Slusarski DC, Corces VG, Moon RT., Nature. November 27, 1997; 390 (6658): 410-3.

Analysis of the signaling activities of localization mutants of beta-catenin during axis specification in Xenopus., Miller JR, Moon RT., J Cell Biol. October 6, 1997; 139 (1): 229-43.                

Positive and negative regulation of muscle cell identity by members of the hedgehog and TGF-beta gene families., Du SJ, Devoto SH, Westerfield M, Moon RT., J Cell Biol. October 6, 1997; 139 (1): 145-56.              

A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus., Brannon M, Gomperts M, Sumoy L, Moon RT, Kimelman D., Genes Dev. September 15, 1997; 11 (18): 2359-70.

Structurally related receptors and antagonists compete for secreted Wnt ligands., Moon RT, Brown JD, Yang-Snyder JA, Miller JR., Cell. March 21, 1997; 88 (6): 725-8.

Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway., Larabell CA, Torres M, Rowning BA, Yost C, Miller JR, Wu M, Kimelman D, Moon RT., J Cell Biol. March 10, 1997; 136 (5): 1123-36.                

Microtubule-mediated transport of organelles and localization of beta-catenin to the future dorsal side of Xenopus eggs., Rowning BA, Wells J, Wu M, Gerhart JC, Moon RT, Larabell CA., Proc Natl Acad Sci U S A. February 18, 1997; 94 (4): 1224-9.

Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos., Hoppler S, Brown JD, Moon RT., Genes Dev. November 1, 1996; 10 (21): 2805-17.            

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