Results 1 - 50 of 209 results
Deterministic nuclear reprogramming of mammalian nuclei to a totipotency-like state by Amphibian meiotic oocytes for stem cell therapy in humans. , Wen MH, Barbosa Triana H, Butler R, Hu HW, Dai YH, Lawrence N, Hong JJ, Garrett N, Jones-Green R, Rawlins EL, Dong Z, Koziol MJ, Gurdon JB ., Biol Open. March 1, 2024; 13 (3):
The initiation and maintenance of a differentiated state in development. , Javed K, Gurdon JB ., Dev Biol. March 1, 2022; 483 34-38.
DNA-induced spatial entrapment of general transcription machinery can stabilize gene expression in a nondividing cell. , Javed K, Jullien J , Agarwal G, Lawrence N, Butler R, Ioannou PS, Nazir F, Gurdon JB ., Proc Natl Acad Sci U S A. January 25, 2022; 119 (4):
A Brief History of Xenopus in Biology. , De Robertis EM , Gurdon JB ., Cold Spring Harb Protoc. December 1, 2021; 2021 (12):
Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs. , Aztekin C , Hiscock TW, Gurdon J , Jullien J , Marioni J, Simons BD., Development. June 1, 2021; 148 (11):
Injected cells provide a valuable complement to cell-free systems for analysis of gene expression. , Gurdon JB , Javed K, Wen MH, Barbosa Triana HM., Exp Cell Res. November 15, 2020; 396 (2): 112296.
Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription. , Oikawa M, Simeone A, Hormanseder E , Teperek M, Gaggioli V, O'Doherty A, Falk E, Sporniak M, D'Santos C, Franklin VNR, Kishore K, Bradshaw CR , Keane D, Freour T, David L, Grzybowski AT, Ruthenburg AJ, Gurdon J , Jullien J ., Nat Commun. July 13, 2020; 11 (1): 3491.
Long-term association of a transcription factor with its chromatin binding site can stabilize gene expression and cell fate commitment. , Gurdon JB , Javed K, Vodnala M, Garrett N., Proc Natl Acad Sci U S A. June 30, 2020; 117 (26): 15075-15084.
The myeloid lineage is required for the emergence of a regeneration-permissive environment following Xenopus tail amputation. , Aztekin C , Hiscock TW, Butler R, De Jesús Andino F, Robert J , Gurdon JB , Jullien J ., Development. February 5, 2020; 147 (3):
Identification of a regeneration-organizing cell in the Xenopus tail. , Aztekin C , Hiscock TW, Marioni JC, Gurdon JB , Simons BD, Jullien J ., Science. May 17, 2019; 364 (6441): 653-658.
Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes. , Miyamoto K , Nguyen KT, Allen GE, Jullien J , Kumar D , Otani T, Bradshaw CR , Livesey FJ, Kellis M, Gurdon JB ., Cell Rep. July 10, 2018; 24 (2): 304-311.
H3K4 Methylation-Dependent Memory of Somatic Cell Identity Inhibits Reprogramming and Development of Nuclear Transfer Embryos. , Hörmanseder E , Simeone A, Allen GE, Bradshaw CR , Figlmüller M, Gurdon J , Jullien J ., Cell Stem Cell. July 6, 2017; 21 (1): 135-143.e6.
Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways. , Jullien J , Vodnala M, Pasque V, Oikawa M, Miyamoto K , Allen G, David SA, Brochard V, Wang S, Bradshaw C , Koseki H, Sartorelli V, Beaujean N, Gurdon J ., Mol Cell. March 2, 2017; 65 (5): 873-884.e8.
Nuclear transplantation, the conservation of the genome, and prospects for cell replacement. , Gurdon JB ., FEBS J. January 1, 2017; 284 (2): 211-217.
Sperm is epigenetically programmed to regulate gene transcription in embryos. , Teperek M, Simeone A, Gaggioli V, Miyamoto K , Allen GE, Erkek S, Kwon T , Marcotte EM , Zegerman P, Bradshaw CR , Peters AH, Gurdon JB , Jullien J ., Genome Res. August 1, 2016; 26 (8): 1034-46.
Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications. , Koziol MJ, Bradshaw CR , Allen GE, Costa ASH, Frezza C, Gurdon JB ., Nat Struct Mol Biol. January 1, 2016; 23 (1): 24-30.
Cell Fate Determination by Transcription Factors. , Gurdon JB ., Curr Top Dev Biol. January 1, 2016; 116 445-54.
The Expression of TALEN before Fertilization Provides a Rapid Knock-Out Phenotype in Xenopus laevis Founder Embryos. , Miyamoto K , Suzuki KT , Suzuki M , Sakane Y, Sakuma T, Herberg S, Simeone A, Simpson D, Jullien J , Yamamoto T , Gurdon JB ., PLoS One. November 18, 2015; 10 (11): e0142946.
Histone H3 lysine 9 trimethylation is required for suppressing the expression of an embryonically activated retrotransposon in Xenopus laevis. , Herberg S, Simeone A, Oikawa M, Jullien J , Bradshaw CR , Teperek M, Gurdon J , Miyamoto K ., Sci Rep. September 21, 2015; 5 14236.
Harveian Oration 2014: Stem cells and cell replacement prospects . , Gurdon J ., Clin Med (Lond). April 1, 2015; 15 (2): 160-7.
Manipulation and in vitro maturation of Xenopus laevis oocytes, followed by intracytoplasmic sperm injection, to study embryonic development. , Miyamoto K , Simpson D, Gurdon JB ., J Vis Exp. February 9, 2015; (96): e52496.
Initiation and maintenance of pluripotency gene expression in the absence of cohesin. , Lavagnolli T, Gupta P, Hörmanseder E , Mira-Bontenbal H, Dharmalingam G, Carroll T , Gurdon JB , Fisher AG, Merkenschlager M., Genes Dev. January 1, 2015; 29 (1): 23-38.
Sperm and spermatids contain different proteins and bind distinct egg factors. , Teperek M, Miyamoto K , Simeone A, Feret R, Deery MJ, Gurdon JB , Jullien J ., Int J Mol Sci. September 19, 2014; 15 (9): 16719-40.
Hierarchical molecular events driven by oocyte-specific factors lead to rapid and extensive reprogramming. , Jullien J , Miyamoto K , Pasque V, Allen GE, Bradshaw CR , Garrett NJ, Halley-Stott RP, Kimura H, Ohsumi K, Gurdon JB ., Mol Cell. August 21, 2014; 55 (4): 524-36.
Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP. , Wickramasinghe VO, Andrews R, Ellis P, Langford C, Gurdon JB , Stewart M, Venkitaraman AR, Laskey RA., Nucleic Acids Res. April 1, 2014; 42 (8): 5059-71.
A view of amphibian embryology during the last century. , Gurdon JB ., Int J Dev Biol. January 1, 2014; 58 (10-12): 723-5.
The egg and the nucleus: a battle for supremacy (Nobel Lecture). , Gurdon JB ., Angew Chem Int Ed Engl. December 23, 2013; 52 (52): 13890-9.
Transcriptional regulation and nuclear reprogramming: roles of nuclear actin and actin-binding proteins. , Miyamoto K , Gurdon JB ., Cell Mol Life Sci. September 1, 2013; 70 (18): 3289-302.
Nuclear Wave1 is required for reprogramming transcription in oocytes and for normal development. , Miyamoto K , Teperek M, Yusa K, Allen GE, Bradshaw CR , Gurdon JB ., Science. August 30, 2013; 341 (6149): 1002-5.
The egg and the nucleus: a battle for supremacy. , Gurdon JB ., Development. June 1, 2013; 140 (12): 2449-56.
The cloning of a frog. , Gurdon JB ., Development. June 1, 2013; 140 (12): 2446-8.
HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes. , Jullien J , Astrand C, Szenker E, Garrett N, Almouzni G , Gurdon JB ., Epigenetics Chromatin. October 29, 2012; 5 (1): 17.
On the cellular and developmental lethality of a Xenopus nucleocytoplasmic hybrid. , Narbonne P, Halley-Stott RP, Gurdon JB ., Commun Integr Biol. July 1, 2012; 5 (4): 329-33.
Widespread transcription in an amphibian oocyte relates to its reprogramming activity on transplanted somatic nuclei. , Simeoni I, Gilchrist MJ , Garrett N, Armisen J, Gurdon JB ., Stem Cells Dev. January 20, 2012; 21 (2): 181-90.
Amphibian interorder nuclear transfer embryos reveal conserved embryonic gene transcription, but deficient DNA replication or chromosome segregation. , Narbonne P, Gurdon JB ., Int J Dev Biol. January 1, 2012; 56 (10-12): 975-86.
Epigenetic factors influencing resistance to nuclear reprogramming. , Pasque V, Jullien J , Miyamoto K , Halley-Stott RP, Gurdon JB ., Trends Genet. December 1, 2011; 27 (12): 516-25.
Deficient induction response in a Xenopus nucleocytoplasmic hybrid. , Narbonne P, Simpson DE, Gurdon JB ., PLoS Biol. November 1, 2011; 9 (11): e1001197.
Nuclear actin in transcriptional reprogramming by oocytes: are actin nucleators key players? , Miyamoto K , Pasque V, Gurdon JB ., Cell Cycle. September 15, 2011; 10 (18): 3040-1.
Nuclear actin and transcriptional activation. , Miyamoto K , Gurdon JB ., Commun Integr Biol. September 1, 2011; 4 (5): 582-3.
Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process? , Jullien J , Pasque V, Halley-Stott RP, Miyamoto K , Gurdon JB ., Nat Rev Mol Cell Biol. June 23, 2011; 12 (7): 453-9.
Nuclear transfer to eggs and oocytes. , Gurdon JB , Wilmut I., Cold Spring Harb Perspect Biol. June 1, 2011; 3 (6):
Histone variant macroH2A confers resistance to nuclear reprogramming. , Pasque V, Gillich A, Garrett N, Gurdon JB ., EMBO J. May 6, 2011; 30 (12): 2373-87.
Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. , Miyamoto K , Pasque V, Jullien J , Gurdon JB ., Genes Dev. May 1, 2011; 25 (9): 946-58.
Reprogramming of gene expression following nuclear transfer to the Xenopus oocyte. , Jullien J , Gurdon J ., Biol Aujourdhui. January 1, 2011; 205 (2): 105-10.
Epigenetic stability of repressed states involving the histone variant macroH2A revealed by nuclear transfer to Xenopus oocytes. , Pasque V, Halley-Stott RP, Gillich A, Garrett N, Gurdon JB ., Nucleus. January 1, 2011; 2 (6): 533-9.
Mammalian nuclear transplantation to Germinal Vesicle stage Xenopus oocytes - a method for quantitative transcriptional reprogramming. , Halley-Stott RP, Pasque V, Astrand C, Miyamoto K , Simeoni I, Jullien J , Gurdon JB ., Methods. May 1, 2010; 51 (1): 56-65.
Characterization of somatic cell nuclear reprogramming by oocytes in which a linker histone is required for pluripotency gene reactivation. , Jullien J , Astrand C, Halley-Stott RP, Garrett N, Gurdon JB ., Proc Natl Acad Sci U S A. March 23, 2010; 107 (12): 5483-8.
Histone H3 lysine 4 methylation is associated with the transcriptional reprogramming efficiency of somatic nuclei by oocytes. , Murata K, Kouzarides T, Bannister AJ, Gurdon JB ., Epigenetics Chromatin. February 4, 2010; 3 (1): 4.
Nuclear reprogramming in eggs. , Gurdon J ., Nat Med. October 1, 2009; 15 (10): 1141-4.
Xenopus oocytes reactivate muscle gene transcription in transplanted somatic nuclei independently of myogenic factors. , Biddle A, Simeoni I, Gurdon JB ., Development. August 1, 2009; 136 (16): 2695-703.