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Summary Expression Phenotypes Gene Literature (25) GO Terms (9) Nucleotides (71) Proteins (43) Interactants (194) Wiki
XB-GENEPAGE-994090

Papers associated with lgr5



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Essential roles of YAP-TEAD complex in adult stem cell development during thyroid hormone-induced intestinal remodeling of Xenopus laevis., Hasebe T, Fujimoto K, Ishizuya-Oka A., Cell Tissue Res. May 1, 2022; 388 (2): 313-329.


Tril dampens Nodal signaling through Pellino2- and Traf6-mediated activation of Nedd4l., Kim HS, Green YS, Xie Y, Christian JL., Proc Natl Acad Sci U S A. September 7, 2021; 118 (36):                       


Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification., Reis AH, Sokol SY., Sci Rep. June 28, 2021; 11 (1): 13433.            


Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs., Aztekin C, Hiscock TW, Gurdon J, Jullien J, Marioni J, Simons BD., Development. June 1, 2021; 148 (11):                                             


The development of adult intestinal stem cells: Insights from studies on thyroid hormone-dependent anuran metamorphosis., Shi YB, Shi YB, Shibata Y, Tanizaki Y, Fu L., Vitam Horm. January 1, 2021; 116 269-293.


Thyroid hormone-induced expression of Foxl1 in subepithelial fibroblasts correlates with adult stem cell development during Xenopus intestinal remodeling., Hasebe T, Fujimoto K, Ishizuya-Oka A., Sci Rep. November 26, 2020; 10 (1): 20715.                


Effects of bisphenol A and its alternative bisphenol F on Notch signaling and intestinal development: A novel signaling by which bisphenols disrupt vertebrate development., Zhu M, Li Y, Niu Y, Li J, Qin Z., Environ Pollut. August 1, 2020; 263 (Pt B): 114443.


Involvement of epigenetic modifications in thyroid hormone-dependent formation of adult intestinal stem cells during amphibian metamorphosis., Fu L, Yin J, Shi YB., Gen Comp Endocrinol. January 15, 2019; 271 91-96.      


Expression of hyaluronan synthases upregulated by thyroid hormone is involved in intestinal stem cell development during Xenopus laevis metamorphosis., Fujimoto K, Hasebe T, Kajita M, Ishizuya-Oka A., Dev Genes Evol. December 1, 2018; 228 (6): 267-273.


RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6., Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lefèvre C, Khatoo M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C, de Sousa SB, Karaman B, Latypova X, Başaran S, Yücel EB, Tan TT, Vlaminck L, Nayak SS, Shukla A, Girisha KM, Le Caignec C, Soshnikova N, Uyguner ZO, Vleminckx K, Vleminckx K, Barker N, Kayserili H, Reversade B., Nature. May 1, 2018; 557 (7706): 564-569.  


Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover., Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C., Dev Cell. October 9, 2017; 43 (1): 71-82.e6.                                


Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors., Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ., Sci Signal. June 27, 2017; 10 (485):


Thyroid Hormone-Induced Activation of Notch Signaling is Required for Adult Intestinal Stem Cell Development During Xenopus Laevis Metamorphosis., Hasebe T, Fujimoto K, Kajita M, Fu L, Shi YB, Shi YB, Ishizuya-Oka A., Stem Cells. April 1, 2017; 35 (4): 1028-1039.            


The Sox transcriptional factors: Functions during intestinal development in vertebrates., Fu L, Shi YB., Semin Cell Dev Biol. March 1, 2017; 63 58-67.        


Thyroid hormone activates Wnt/β-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis., Hasebe T, Fujimoto K, Kajita M, Ishizuya-Oka A., Cell Tissue Res. August 1, 2016; 365 (2): 309-18.


Molecular and cytological analyses reveal distinct transformations of intestinal epithelial cells during Xenopus metamorphosis., Okada M, Wen L, Miller TC, Su D, Shi YB., Cell Biosci. January 1, 2015; 5 74.                                


The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength., de Lau W, Peng WC, Gros P, Clevers H., Genes Dev. February 15, 2014; 28 (4): 305-16.          


Crystal structures of Lgr4 and its complex with R-spondin1., Xu K, Xu Y, Xu Y, Rajashankar KR, Robev D, Nikolov DB., Structure. September 3, 2013; 21 (9): 1683-9.


Multi-functional norrin is a ligand for the LGR4 receptor., Deng C, Reddy P, Cheng Y, Luo CW, Hsiao CL, Hsueh AJ., J Cell Sci. May 1, 2013; 126 (Pt 9): 2060-8.                                  


Imparting regenerative capacity to limbs by progenitor cell transplantation., Lin G, Chen Y, Chen Y, Slack JM., Dev Cell. January 14, 2013; 24 (1): 41-51.                          


Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin., Zebisch M, Xu Y, Xu Y, Krastev C, MacDonald BT, Chen M, Gilbert RJ, He X, Jones EY., Nat Commun. January 1, 2013; 4 2787.              


Thyroid hormone regulation of adult intestinal stem cell development: mechanisms and evolutionary conservations., Sun G, Shi YB., Int J Biol Sci. January 1, 2012; 8 (8): 1217-24.      


LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling., Glinka A, Dolde C, Kirsch N, Huang YL, Kazanskaya O, Ingelfinger D, Boutros M, Cruciat CM, Niehrs C., EMBO Rep. September 30, 2011; 12 (10): 1055-61.


Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro., Spence JR, Mayhew CN, Rankin SA, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM., Nature. February 3, 2011; 470 (7332): 105-9.      


Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-dependent metamorphosis in Xenopus laevis., Sun G, Hasebe T, Fujimoto K, Lu R, Fu L, Matsuda H, Kajita M, Ishizuya-Oka A, Shi YB., PLoS One. October 22, 2010; 5 (10): e13605.                    

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