Papers associated with kcnh2

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	Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncology., Sakellakis M, Yoon SM, Reet J, Chalkias A., Channels (Austin). December 1, 2024; 18 (1): 2297605.
	Functional and clinical characterization of a novel homozygous KCNH2 missense variant in the pore region of Kv11.1 leading to a viable but severe long-QT syndrome., Delinière A, Jaupart L, Janin A, Millat G, Boulin T, Andrini O, Chevalier P., Gene. March 1, 2024; 897 148076.
	The plant-derived alkaloid aloperine prevents ischemia/reperfusion injury-induced sudden cardiac death., Hu Z, Li J, Liu Q, Manville RW, Abbott GW., FASEB J. July 1, 2023; 37 (7): e22999.
	Molecular Determinants for the High-Affinity Blockade of Human Ether-à-go-go-Related Gene K + Channel by Tolterodine., Wang N, Yang Y, Wen J, Fan XR, Li J, Xiong B, Zhang J, Zeng B, Shen JW, Chen GL., J Cardiovasc Pharmacol. November 1, 2022; 80 (5): 679-689.
	Coupling the Cardiac Voltage-Gated Sodium Channel to Channelrhodopsin-2 Generates Novel Optical Switches for Action Potential Studies., Vom Dahl C, Müller CE, Berisha X, Nagel G, Zimmer T., Membranes (Basel). September 20, 2022; 12 (10):
	Loss-of-function variants in Kv 11.1 cardiac channels as a biomarker for SUDEP., Soh MS, Bagnall RD, Bennett MF, Bleakley LE, Mohamed Syazwan ES, Phillips AM, Chiam MDF, McKenzie CE, Hildebrand M, Crompton D, Bahlo M, Semsarian C, Scheffer IE, Berkovic SF, Reid CA., Ann Clin Transl Neurol. July 1, 2021; 8 (7): 1422-1432.
	Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer., Levin M., Cell. April 15, 2021;
	External Cd2+ and protons activate the hyperpolarization-gated K+ channel KAT1 at the voltage sensor., Zhou Y, Assmann SM, Jegla T., J Gen Physiol. January 4, 2021; 153 (1):
	Electrophysiological effects of non-vitamin K antagonist oral anticoagulants on atrial repolarizing potassium channels., Wiedmann F, Schlund D, Kraft M, Nietfeld J, Katus HA, Schmidt C, Thomas D., Europace. September 1, 2020; 22 (9): 1409-1418.
	GiTx1(β/κ-theraphotoxin-Gi1a), a novel toxin from the venom of Brazilian tarantula Grammostola iheringi (Mygalomorphae, Theraphosidae): Isolation, structural assessments and activity on voltage-gated ion channels., Montandon GG, Cassoli JS, Peigneur S, Verano-Braga T, Santos DMD, Paiva ALB, Moraes ÉR, Kushmerick C, Borges MH, Richardson M, Pimenta AMC, Kjeldsen F, Diniz MRV, Tytgat J, Lima ME., Biochimie. September 1, 2020; 176 138-149.
	The hERG channel activator, RPR260243, enhances protective IKr current early in the refractory period reducing arrhythmogenicity in zebrafish hearts., Shi YP, Pang Z, Venkateshappa R, Gunawan M, Kemp J, Truong E, Chang C, Lin E, Shafaattalab S, Faizi S, Rayani K, Tibbits GF, Claydon VE, Claydon TW., Am J Physiol Heart Circ Physiol. August 1, 2020; 319 (2): H251-H261.
	Structure of KCNH2 cyclic nucleotide-binding homology domain reveals a functionally vital salt-bridge., Ben-Bassat A, Giladi M, Haitin Y., J Gen Physiol. April 6, 2020; 152 (4):
	Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms., Bohannon BM, de la Cruz A, Wu X, Jowais JJ, Perez ME, Dykxhoorn DM, Liin SI, Larsson HP., Elife. March 24, 2020; 9
	Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574., Zangerl-Plessl EM, Berger M, Drescher M, Chen Y, Wu W, Maulide N, Sanguinetti M, Stary-Weinzinger A., J Chem Inf Model. January 27, 2020; 60 (1): 360-371.
	Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds., Hull CM, Genge CE, Hobbs Y, Rayani K, Lin E, Gunawan M, Shafaattalab S, Tibbits GF, Claydon TW., Am J Physiol Regul Integr Comp Physiol. December 1, 2019; 317 (6): R921-R931.
	Regulation of Eag1 gating by its intracellular domains., Whicher JR, MacKinnon R., Elife. September 6, 2019; 8
	The molecular determinants of R-roscovitine block of hERG channels., Cernuda B, Fernandes CT, Allam SM, Orzillo M, Suppa G, Chia Chang Z, Athanasopoulos D, Buraei Z., PLoS One. September 3, 2019; 14 (9): e0217733.
	Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels., Chen IS, Liu C, Tateyama M, Karbat I, Uesugi M, Reuveny E, Kubo Y., Br J Pharmacol. September 1, 2019; 176 (17): 3161-3179.
	Temperature Dependence of the Biophysical Mechanisms Underlying the Inhibition and Enhancement Effect of Amiodarone on hERG Channels., Lo YC, Kuo CC., Mol Pharmacol. September 1, 2019; 96 (3): 330-344.
	The acute effects of hydrocortisone on cardiac electrocardiography, action potentials, intracellular calcium, and contraction: The role of protein kinase C., Park MH, Park SI, Kim JH, Yu J, Lee EH, Seo SR, Jo SH., Mol Cell Endocrinol. August 20, 2019; 494 110488.
	Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels., Wang ZJ, Tiwari PB, Üren A, Brelidze TI., BMC Pharmacol Toxicol. July 17, 2019; 20 (1): 42.
	Antinociceptive effects of new pyrazoles compounds mediated by the ASIC-1α channel, TRPV-1 and μMOR receptors., Florentino IF, Silva DPB, Cardoso CS, Menegatti R, de Carvalho FS, Lião LM, Pinto PM, Peigneur S, Costa EA, Tytgat J., Biomed Pharmacother. July 1, 2019; 115 108915.
	Importance of the Choice of a Recombinant System to Produce Large Amounts of Functional Membrane Protein hERG., Vasseur L, Cens T, Wagner R, Saint N, Kugler V, Chavanieu A, Ouvry C, Dupré C, Ferry G, Boutin JA., Int J Mol Sci. June 28, 2019; 20 (13):
	ANK2 functionally interacts with KCNH2 aggravating long QT syndrome in a double mutation carrier., Gessner G, Runge S, Koenen M, Heinemann SH, Koenen M, Haas J, Meder B, Thomas D, Katus HA, Schweizer PA., Biochem Biophys Res Commun. May 14, 2019; 512 (4): 845-851.
	Fluorescent analogues of BeKm-1 with high and specific activity against the hERG channel., Vasseur L, Chavanieu A, Combemale S, Caumes C, Béroud R, De Waard M, Ducrot P, Boutin JA, Ferry G, Cens T., Toxicon X. February 23, 2019; 2 100010.
	A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels., Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter EP, Tucker SJ, Baukrowitz T., Science. February 22, 2019; 363 (6429): 875-880.
	Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations., Furutani K, Tsumoto K, Chen IS, Handa K, Yamakawa Y, Sack JT, Kurachi Y., J Gen Physiol. February 4, 2019; 151 (2): 214-230.
	Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation., Shi YP, Thouta S, Cheng YM, Claydon TW., J Gen Physiol. February 4, 2019; 151 (2): 231-246.
	Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice., Li Y, Sun L, Yang T, Jiao W, Tang J, Huang X, Huang Z, Meng Y, Luo L, Wang X, Bian X, Zhang F, Wang K, Sun Q., J Med Chem. January 10, 2019; 62 (1): 159-173.
	Bipolar switching by HCN voltage sensor underlies hyperpolarization activation., Cowgill J, Klenchin VA, Alvarez-Baron C, Tewari D, Blair A, Chanda B., Proc Natl Acad Sci U S A. January 8, 2019; 116 (2): 670-678.
	Nocturnal Atrial Fibrillation Caused by Mutation in KCND2, Encoding Pore-Forming (α) Subunit of the Cardiac Kv4.2 Potassium Channel., Drabkin M, Zilberberg N, Menahem S, Mulla W, Halperin D, Yogev Y, Wormser O, Perez Y, Kadir R, Etzion Y, Katz A, Birk OS., Circ Genom Precis Med. November 1, 2018; 11 (11): e002293.
	Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain., Kume S, Shimomura T, Tateyama M, Kubo Y., J Physiol. October 1, 2018; 596 (19): 4629-4650.
	Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain., de la Peña P, Domínguez P, Barros F., Pflugers Arch. July 1, 2018; 470 (7): 1069-1085.
	Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo., Baburin I, Varkevisser R, Schramm A, Saxena P, Beyl S, Szkokan P, Linder T, Stary-Weinzinger A, van der Heyden MAG, Houtman M, Takanari H, Jonsson M, Beekman JHD, Hamburger M, Vos MA, Hering S., Pharmacol Res. May 1, 2018; 131 150-163.
	Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels., Dai G, James ZM, Zagotta WN., J Gen Physiol. April 2, 2018; 150 (4): 625-635.
	Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype., Thouta S, Lo G, Grajauskas L, Claydon T., Sci Rep. March 21, 2018; 8 (1): 4962.
	Probing the molecular basis of hERG drug block with unnatural amino acids., Macdonald LC, Kim RY, Kurata HT, Fedida D., Sci Rep. January 10, 2018; 8 (1): 289.
	The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues., Dou Y, Macdonald LC, Wu Y, Fedida D., Biophys J. November 7, 2017; 113 (9): 1979-1991.
	Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3., Gardner A, Wu W, Thomson S, Zangerl-Plessl EM, Stary-Weinzinger A, Sanguinetti MC., Mol Pharmacol. October 1, 2017; 92 (4): 437-450.
	APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel KV10.1., Moreels L, Peigneur S, Galan DT, De Pauw E, Béress L, Waelkens E, Pardo LA, Quinton L, Tytgat J., Mar Drugs. September 13, 2017; 15 (9):
	Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference., Scherer D, Schworm B, Seyler C, Xynogalos P, Scholz EP, Thomas D, Katus HA, Zitron E., Naunyn Schmiedebergs Arch Pharmacol. July 1, 2017; 390 (7): 701-710.
	Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4., Abbott GW., Sci Rep. December 6, 2016; 6 38412.
	Ginsenoside Rg3, a Gating Modifier of EAG Family K+ Channels., Wu W, Gardner A, Sachse FB, Sanguinetti MC., Mol Pharmacol. October 1, 2016; 90 (4): 469-82.
	Mitragynine and its potential blocking effects on specific cardiac potassium channels., Tay YL, Teah YF, Chong YM, Jamil MFA, Kollert S, Adenan MI, Wahab HA, Döring F, Wischmeyer E, Tan ML., Toxicol Appl Pharmacol. August 15, 2016; 305 22-39.
	hERG Channel Blocking Ipecac Alkaloids Identified by Combined In Silico - In Vitro Screening., Kratz JM, Mair CE, Oettl SK, Saxena P, Scheel O, Schuster D, Hering S, Rollinger JM., Planta Med. July 1, 2016; 82 (11-12): 1009-15.
	Molecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine Myocardium., Pedersen PJ, Thomsen KB, Olander ER, Hauser F, Tejada Mde L, Poulsen KL, Grubb S, Buhl R, Calloe K, Klaerke DA., PLoS One. September 4, 2015; 10 (9): e0138320.
	HPLC-Based Activity Profiling for hERG Channel Inhibitors in the South African Medicinal Plant Galenia africana., Du K, De Mieri M, Saxena P, Phungula KV, Wilhelm A, Hrubaru MM, van Rensburg E, Zietsman PC, Hering S, van der Westhuizen JH, Hamburger M., Planta Med. August 1, 2015; 81 (12-13): 1154-62.
	Interactions between the N-terminal tail and the gating machinery of hERG K⁺ channels both in closed and open/inactive states., de la Peña P, Machín A, Fernández-Trillo J, Domínguez P, Barros F., Pflugers Arch. August 1, 2015; 467 (8): 1747-56.
	hERG Channel Inhibitory Daphnane Diterpenoid Orthoesters and Polycephalones A and B with Unprecedented Skeletons from Gnidia polycephala., De Mieri M, Du K, Neuburger M, Saxena P, Zietsman PC, Hering S, van der Westhuizen JH, Hamburger M., J Nat Prod. July 24, 2015; 78 (7): 1697-707.
	C-Linker Accounts for Differential Sensitivity of ERG1 and ERG2 K+ Channels to RPR260243-Induced Slow Deactivation., Gardner A, Sanguinetti MC., Mol Pharmacol. July 1, 2015; 88 (1): 19-28.

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