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Summary Expression Phenotypes Gene Literature (92) GO Terms (0) Nucleotides (58) Proteins (33) Interactants (87) Wiki
XB--1218174

Papers associated with hcn2



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HCN2 channel-induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling., Pai VP, Levin M., Wound Repair Regen. November 1, 2022; 30 (6): 681-706.                      


Effect of Ginkgo biloba extract on pacemaker channels encoded by HCN gene., Chen H, Chen Y, Yang J, Wu P, Wang X, Huang C., Herz. June 1, 2021; 46 (3): 255-261.


Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer., Levin M., Cell. April 15, 2021;               


HCN2 activation modulation: An electrophysiological and molecular study of the well-preserved LCI sequence in the pore channel., Hernandez A, Hernández-Centeno R, Espino-Saldaña ÁE, Martínez-Torres A., Arch Biochem Biophys. August 15, 2020; 689 108436.


The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms., Wang ZJ, Blanco I, Hayoz S, Brelidze TI., J Biol Chem. June 12, 2020; 295 (24): 8164-8173.


HCN2 Channel-Induced Rescue of Brain Teratogenesis via Local and Long-Range Bioelectric Repair., Pai VP, Cervera J, Mafe S, Willocq V, Lederer EK, Levin M., Front Cell Neurosci. January 1, 2020; 14 136.                      


N6-modified cAMP derivatives that activate protein kinase A also act as full agonists of murine HCN2 channels., Leypold T, Bonus M, Spiegelhalter F, Schwede F, Schwabe T, Gohlke H, Kusch J., J Biol Chem. November 22, 2019; 294 (47): 17978-17987.              


Incorporation of one N-glycosylation-deficient subunit within a tetramer of HCN2 channel is tolerated., Kaku R, Matsuoka Y, Yang J., Neuroreport. October 16, 2019; 30 (15): 998-1003.      


cAMP binds to closed, inactivated, and open sea urchin HCN channels in a state-dependent manner., Idikuda V, Gao W, Su Z, Liu Q, Zhou L., J Gen Physiol. February 4, 2019; 151 (2): 200-213.              


The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function., Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L, Decher N., FASEB J. November 1, 2018; 32 (11): 6159-6173.            


Hydrophobic alkyl chains substituted to the 8-position of cyclic nucleotides enhance activation of CNG and HCN channels by an intricate enthalpy - entropy compensation., Otte M, Schweinitz A, Bonus M, Enke U, Schumann C, Gohlke H, Benndorf K., Sci Rep. October 8, 2018; 8 (1): 14960.                        


All four subunits of HCN2 channels contribute to the activation gating in an additive but intricate manner., Sunkara MR, Schwabe T, Ehrlich G, Kusch J, Benndorf K., J Gen Physiol. September 3, 2018; 150 (9): 1261-1271.            


Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family., Alvarez-Baron CP, Klenchin VA, Chanda B., J Gen Physiol. August 6, 2018; 150 (8): 1203-1213.            


Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK., Schmidpeter PAM, Gao X, Uphadyay V, Rheinberger J, Nimigean CM., J Gen Physiol. June 4, 2018; 150 (6): 821-834.          


Shank3-deficient thalamocortical neurons show HCN channelopathy and alterations in intrinsic electrical properties., Zhu M, Idikuda VK, Wang J, Wei F, Kumar V, Shah N, Waite CB, Liu Q, Zhou L., J Physiol. April 1, 2018; 596 (7): 1259-1276.


Activation gating in HCN2 channels., Hummert S, Thon S, Eick T, Schmauder R, Schulz E, Benndorf K., PLoS Comput Biol. March 22, 2018; 14 (3): e1006045.            


HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns., Pai VP, Pietak A, Willocq V, Ye B, Shi NQ, Levin M., Nat Commun. March 8, 2018; 9 (1): 998.                        


Booting up the organism during development: Pre-behavioral functions of the vertebrate brain in guiding body morphogenesis., Herrera-Rincon C, Levin M., Commun Integr Biol. February 15, 2018; 11 (1): e1433440.    


Gain-of-function HCN2 variants in genetic epilepsy., Li M, Maljevic S, Phillips AM, Petrovski S, Hildebrand MS, Burgess R, Mount T, Zara F, Striano P, Schubert J, Thiele H, Nürnberg P, Wong M, Weisenberg JL, Thio LL, Lerche H, Scheffer IE, Berkovic SF, Petrou S, Reid CA., Hum Mutat. February 1, 2018; 39 (2): 202-209.


Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b., Bankston JR, DeBerg HA, Stoll S, Zagotta WN., J Biol Chem. October 27, 2017; 292 (43): 17794-17803.


HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner., Pai VP, Willocq V, Pitcairn EJ, Lemire JM, Paré JF, Shi NQ, McLaughlin KA, Levin M., Biol Open. October 15, 2017; 6 (10): 1445-1457.                              


The brain is required for normal muscle and nerve patterning during early Xenopus development., Herrera-Rincon C, Pai VP, Moran KM, Lemire JM, Levin M., Nat Commun. September 25, 2017; 8 (1): 587.              


Gabapentin Modulates HCN4 Channel Voltage-Dependence., Tae HS, Smith KM, Phillips AM, Boyle KA, Li M, Forster IC, Hatch RJ, Richardson R, Hughes DI, Graham BA, Petrou S, Reid CA., Front Pharmacol. May 26, 2017; 8 554.            


A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction., Stallmeyer B, Kuß J, Kotthoff S, Zumhagen S, Vowinkel K, Rinné S, Matschke LA, Friedrich C, Schulze-Bahr E, Rust S, Seebohm G, Decher N, Schulze-Bahr E., Circ Res. May 12, 2017; 120 (10): e33-e44.


Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis in Xenopus laevis., Pitcairn E, Harris H, Epiney J, Pai VP, Lemire JM, Ye B, Shi NQ, Levin M, McLaughlin KA., Commun Integr Biol. May 10, 2017; 10 (3): e1309488.                            


Patch-clamp fluorometry-based channel counting to determine HCN channel conductance., Liu C, Xie C, Grant K, Su Z, Gao W, Liu Q, Zhou L., J Gen Physiol. July 1, 2016; 148 (1): 65-76.          


The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contain multiple S-palmitoylation sites., Itoh M, Ishihara K, Nakashima N, Takano M., J Physiol Sci. May 1, 2016; 66 (3): 241-8.


HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition., Magee KE, Madden Z, Young EC., J Membr Biol. December 1, 2015; 248 (6): 1043-60.


Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides., Thon S, Schulz E, Kusch J, Benndorf K., Biophys J. December 1, 2015; 109 (11): 2268-76.            


An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities., Wemhöner K, Kanyshkova T, Silbernagel N, Fernandez-Orth J, Bittner S, Kiper AK, Rinné S, Netter MF, Meuth SG, Budde T, Decher N., Front Mol Neurosci. November 3, 2015; 8 63.          


Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b., DeBerg HA, Bankston JR, Rosenbaum JC, Brzovic PS, Zagotta WN, Stoll S., Structure. April 7, 2015; 23 (4): 734-44.


HCN2 channels: a permanent open state and conductance changes., Pittoors F, Van Bogaert PP., J Membr Biol. February 1, 2015; 248 (1): 67-81.


cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore., Lyashchenko AK, Redd KJ, Goldstein PA, Tibbs GR., PLoS One. July 1, 2014; 9 (7): e101236.                    


State-dependent and site-directed photodynamic transformation of HCN2 channel by singlet oxygen., Gao W, Su Z, Liu Q, Zhou L., J Gen Physiol. May 1, 2014; 143 (5): 633-44.              


Avoiding the formation of vesicles by patch excision from Xenopus oocytes., Thon S, Benndorf K., J Neurosci Methods. March 30, 2014; 225 29-31.


Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP., Hu L, Santoro B, Saponaro A, Liu H, Moroni A, Siegelbaum S., J Gen Physiol. December 1, 2013; 142 (6): 599-612.                  


Flavonoid regulation of HCN2 channels., Carlson AE, Rosenbaum JC, Brelidze TI, Klevit RE, Zagotta WN., J Biol Chem. November 15, 2013; 288 (46): 33136-45.


Elementary functional properties of single HCN2 channels., Thon S, Schmauder R, Benndorf K., Biophys J. October 1, 2013; 105 (7): 1581-9.


HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain., Tibbs GR, Rowley TJ, Sanford RL, Herold KF, Proekt A, Hemmings HC, Andersen OS, Goldstein PA, Flood PD., J Pharmacol Exp Ther. June 1, 2013; 345 (3): 363-73.


Flavonoid regulation of EAG1 channels., Carlson AE, Brelidze TI, Zagotta WN., J Gen Physiol. March 1, 2013; 141 (3): 347-58.                  


Protein kinase C activation inhibits rat and human hyperpolarization activated cyclic nucleotide gated channel (HCN)1--mediated current in mammalian cells., Reetz O, Strauss U., Cell Physiol Biochem. January 1, 2013; 31 (4-5): 532-41.


Ethanol enhances human hyperpolarization-activated cyclic nucleotide-gated currents., Chen Y, Wu P, Fan X, Chen H, Yang J, Song T, Huang C., Alcohol Clin Exp Res. December 1, 2012; 36 (12): 2036-46.


A leucine zipper motif essential for gating of hyperpolarization-activated channels., Wemhöner K, Silbernagel N, Marzian S, Netter MF, Rinné S, Stansfeld PJ, Decher N., J Biol Chem. November 23, 2012; 287 (48): 40150-60.


Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel., Wu S, Gao W, Xie C, Xu X, Vorvis C, Marni F, Hackett AR, Liu Q, Zhou L., J Gen Physiol. July 1, 2012; 140 (1): 29-39.            


Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels., Bankston JR, Camp SS, DiMaio F, Lewis AS, Chetkovich DM, Zagotta WN., Proc Natl Acad Sci U S A. May 15, 2012; 109 (20): 7899-904.


Asymmetric divergence in structure and function of HCN channel duplicates in Ciona intestinalis., Jackson HA, Hegle A, Nazzari H, Jegla T, Accili EA., PLoS One. January 1, 2012; 7 (11): e47590.                


Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels., Lolicato M, Nardini M, Gazzarrini S, Möller S, Bertinetti D, Herberg FW, Bolognesi M, Martin H, Fasolini M, Bertrand JA, Arrigoni C, Thiel G, Moroni A., J Biol Chem. December 30, 2011; 286 (52): 44811-20.


The hyperpolarization-activated cyclic nucleotide-gated HCN2 channel transports ammonium in the distal nephron., Carrisoza-Gaytán R, Rangel C, Salvador C, Saldaña-Meyer R, Escalona C, Satlin LM, Liu W, Zavilowitz B, Trujillo J, Bobadilla NA, Escobar LI., Kidney Int. October 1, 2011; 80 (8): 832-40.


A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties., Peigneur S, Billen B, Derua R, Waelkens E, Debaveye S, Béress L, Tytgat J., Biochem Pharmacol. July 1, 2011; 82 (1): 81-90.


Local anesthetic inhibits hyperpolarization-activated cationic currents., Meng QT, Xia ZY, Liu J, Bayliss DA, Chen X., Mol Pharmacol. May 1, 2011; 79 (5): 866-73.

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