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Summary Expression Phenotypes Gene Literature (105) GO Terms (5) Nucleotides (93) Proteins (35) Interactants (862) Wiki
XB-GENEPAGE-6258962

Papers associated with lefty



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Embryonic asymmetry: left TGFbeta at the right time?, King T, Brown NA., Curr Biol. April 1, 1997; 7 (4): R212-5.

Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos., Meno C, Ito Y, Saijoh Y, Matsuda Y, Tashiro K, Kuhara S, Hamada H., Genes Cells. August 1, 1997; 2 (8): 513-24.    

Molecular mechanisms of vertebrate left-right development., Ramsdell AF, Yost HJ., Trends Genet. November 1, 1998; 14 (11): 459-65.

Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis., Chazaud C, Chambon P, Dollé P., Development. June 1, 1999; 126 (12): 2589-96.

The SIL gene is required for mouse embryonic axial development and left-right specification., Izraeli S, Lowe LA, Bertness VL, Good DJ, Dorward DW, Kirsch IR, Kuehn MR., Nature. June 17, 1999; 399 (6737): 691-4.

Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression., Yokouchi Y, Vogan KJ, Pearse RV, Tabin CJ., Cell. September 3, 1999; 98 (5): 573-83.

The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry., Rodríguez Esteban C, Capdevila J, Economides AN, Pascual J, Ortiz A, Izpisúa Belmonte JC., Nature. September 16, 1999; 401 (6750): 243-51.

Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation., Hashimoto H, Itoh M, Yamanaka Y, Yamashita S, Shimizu T, Solnica-Krezel L, Hibi M, Hirano T., Dev Biol. January 1, 2000; 217 (1): 138-52.  

Mesendoderm and left-right brain, heart and gut development are differentially regulated by pitx2 isoforms., Essner JJ, Branford WW, Zhang J, Yost HJ., Development. March 1, 2000; 127 (5): 1081-93.      

The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus., Cheng AM, Thisse B, Thisse C, Wright CV., Development. March 1, 2000; 127 (5): 1049-61.                

Nodal signaling patterns the organizer., Gritsman K, Talbot WS, Schier AF., Development. March 1, 2000; 127 (5): 921-32.

Mechanisms of left-right determination in vertebrates., Capdevila J, Vogan KJ, Tabin CJ, Izpisúa Belmonte JC., Cell. March 31, 2000; 101 (1): 9-21.          

The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination., Murcia NS, Richards WG, Yoder BK, Mucenski ML, Dunlap JR, Woychik RP., Development. June 1, 2000; 127 (11): 2347-55.

Regulation of gut and heart left-right asymmetry by context-dependent interactions between xenopus lefty and BMP4 signaling., Branford WW, Essner JJ, Yost HJ., Dev Biol. July 15, 2000; 223 (2): 291-306.              

Expression of the zinc finger gene fez-like in zebrafish forebrain., Hashimoto H, Yabe T, Hirata T, Shimizu T, Bae Y, Yamanaka Y, Hirano T, Hibi M., Mech Dev. October 1, 2000; 97 (1-2): 191-5.

Expression cloning of Xantivin, a Xenopus lefty/antivin-related gene, involved in the regulation of activin signaling during mesoderm induction., Tanegashima K, Yokota C, Takahashi S, Asashima M., Mech Dev. December 1, 2000; 99 (1-2): 3-14.  

Dickkopf1 and the Spemann-Mangold head organizer., Niehrs C, Kazanskaya O, Wu W, Glinka A., Int J Dev Biol. January 1, 2001; 45 (1): 237-40.    

The pitx2 homeobox protein is required early for endoderm formation and nodal signaling. ., Faucourt M, Houliston E, Besnardeau L, Kimelman D, Lepage T., Dev Biol. January 15, 2001; 229 (2): 287-306.                

Neural induction in the absence of mesoderm: beta-catenin-dependent expression of secreted BMP antagonists at the blastula stage in Xenopus., Wessely O, Agius E, Oelgeschläger M, Pera EM, De Robertis EM., Dev Biol. June 1, 2001; 234 (1): 161-73.              

Timing of endogenous activin-like signals and regional specification of the Xenopus embryo., Lee MA, Heasman J, Whitman M., Development. August 1, 2001; 128 (15): 2939-52.            

Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor., Kramer KL, Yost HJ., Dev Cell. January 1, 2002; 2 (1): 115-24.  

Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion., Sakuma R, Ohnishi Yi Y, Meno C, Fujii H, Juan H, Takeuchi J, Ogura T, Li E, Miyazono K, Hamada H., Genes Cells. April 1, 2002; 7 (4): 401-12.

Asymmetries in H+/K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning., Levin M, Thorlin T, Robinson KR, Nogi T, Mercola M., Cell. October 4, 2002; 111 (1): 77-89.              

Lefty-dependent inhibition of Nodal- and Wnt-responsive organizer gene expression is essential for normal gastrulation., Branford WW, Yost HJ., Curr Biol. December 23, 2002; 12 (24): 2136-41.              

PKCgamma regulates syndecan-2 inside-out signaling during xenopus left-right development., Kramer KL, Barnette JE, Yost HJ., Cell. December 27, 2002; 111 (7): 981-90.                

Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein., Mogi K, Goto M, Ohno E, Azumi Y, Takeuchi S, Toyoizumi R., Int J Dev Biol. February 1, 2003; 47 (1): 15-29.                  

Regulation of nodal and BMP signaling by tomoregulin-1 (X7365) through novel mechanisms., Chang C, Eggen BJ, Weinstein DC, Brivanlou AH., Dev Biol. March 1, 2003; 255 (1): 1-11.                    

Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality., Concha ML, Russell C, Regan JC, Tawk M, Sidi S, Gilmour DT, Kapsimali M, Sumoy L, Goldstone K, Amaya E, Kimelman D, Nicolson T, Gründer S, Gomperts M, Clarke JD, Wilson SW., Neuron. July 31, 2003; 39 (3): 423-38.

Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors., Cheng SK, Olale F, Brivanlou AH, Schier AF., PLoS Biol. February 1, 2004; 2 (2): E30.                  

The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish., Hashimoto H, Rebagliati M, Ahmad N, Muraoka O, Kurokawa T, Hibi M, Suzuki T., Development. April 1, 2004; 131 (8): 1741-53.

Two modes by which Lefty proteins inhibit nodal signaling., Chen C, Shen MM., Curr Biol. April 6, 2004; 14 (7): 618-24.

Xantivin suppresses the activity of EGF-CFC genes to regulate nodal signaling., Tanegashima K, Haramoto Y, Yokota C, Takahashi S, Asashima M., Int J Dev Biol. June 1, 2004; 48 (4): 275-83.          

Xenopus nodal related-1 is indispensable only for left-right axis determination., Toyoizumi R, Ogasawara T, Takeuchi S, Mogi K., Int J Dev Biol. January 1, 2005; 49 (8): 923-38.                

Exploration of the extracellular space by a large-scale secretion screen in the early Xenopus embryo., Pera EM, Hou S, Strate I, Wessely O, De Robertis EM., Int J Dev Biol. January 1, 2005; 49 (7): 781-96.                                  

Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos., Fukumoto T, Kema IP, Levin M., Curr Biol. May 10, 2005; 15 (9): 794-803.      

Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis., Bisgrove BW, Snarr BS, Emrazian A, Yost HJ., Dev Biol. November 15, 2005; 287 (2): 274-88.

The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo., Chen C, Ware SM, Sato A, Houston-Hawkins DE, Habas R, Matzuk MM, Shen MM, Brown CW., Development. January 1, 2006; 133 (2): 319-29.              

XCR2, one of three Xenopus EGF-CFC genes, has a distinct role in the regulation of left-right patterning., Onuma Y, Yeo CY, Whitman M., Development. January 1, 2006; 133 (2): 237-50.                                      

Cooperative non-cell and cell autonomous regulation of Nodal gene expression and signaling by Lefty/Antivin and Brachyury in Xenopus., Cha YR, Takahashi S, Wright CV., Dev Biol. February 15, 2006; 290 (2): 246-64.                        

Nodal-related gene Xnr5 is amplified in the Xenopus genome., Takahashi S, Onuma Y, Yokota C, Westmoreland JJ, Asashima M, Wright CV., Genesis. July 1, 2006; 44 (7): 309-21.          

Formation of the ascidian epidermal sensory neurons: insights into the origin of the chordate peripheral nervous system., Pasini A, Amiel A, Rothbächer U, Roure A, Lemaire P, Darras S., PLoS Biol. July 1, 2006; 4 (7): e225.              

Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo., Ho DM, Chan J, Bayliss P, Whitman M., Dev Biol. July 15, 2006; 295 (2): 730-42.            

Subtilisin-like proprotein convertase activity is necessary for left-right axis determination in Xenopus neurula embryos., Toyoizumi R, Takeuchi S, Mogi K., Dev Genes Evol. October 1, 2006; 216 (10): 607-22.

Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides., Rana AA, Collart C, Gilchrist MJ, Smith JC., PLoS Genet. November 17, 2006; 2 (11): e193.                                    

Anteriorward shifting of asymmetric Xnr1 expression and contralateral communication in left-right specification in Xenopus., Ohi Y, Wright CV., Dev Biol. January 15, 2007; 301 (2): 447-63.

The left-right axis is regulated by the interplay of Coco, Xnr1 and derrière in Xenopus embryos., Vonica A, Brivanlou AH., Dev Biol. March 1, 2007; 303 (1): 281-94.              

Evolution of axis specification mechanisms in jawed vertebrates: insights from a chondrichthyan., Coolen M, Sauka-Spengler T, Nicolle D, Le-Mentec C, Lallemand Y, Da Silva C, Plouhinec JL, Robert B, Wincker P, Shi DL, Mazan S., PLoS One. April 18, 2007; 2 (4): e374.              

Xenopus Lefty requires proprotein cleavage but not N-linked glycosylation to inhibit nodal signaling., Westmoreland JJ, Takahashi S, Wright CV., Dev Dyn. August 1, 2007; 236 (8): 2050-61.        

Long-range action of Nodal requires interaction with GDF1., Tanaka C, Sakuma R, Nakamura T, Hamada H, Saijoh Y., Genes Dev. December 15, 2007; 21 (24): 3272-82.        

Transcriptional response of Mexican axolotls to Ambystoma tigrinum virus (ATV) infection., Cotter JD, Storfer A, Page RB, Beachy CK, Voss SR., BMC Genomics. October 20, 2008; 9 493.      

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