Papers associated with kcnh2

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	Movement of the S4 segment in the hERG potassium channel during membrane depolarization., Elliott DJ, Dondas NY, Munsey TS, Sivaprasadarao A., Mol Membr Biol. December 1, 2009; 26 (8): 435-47.
	Inhibition of the human ether-a-go-go-related gene (HERG) K+ channels by Lindera erythrocarpa., Hong HK, Yoon WJ, Kim YH, Yoo ES, Jo SH., J Korean Med Sci. December 1, 2009; 24 (6): 1089-98.
	PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance., Perry M, Sachse FB, Abbruzzese J, Sanguinetti MC., Proc Natl Acad Sci U S A. November 24, 2009; 106 (47): 20075-80.
	H(1) antihistamine drug promethazine directly blocks hERG K(+) channel., Jo SH, Hong HK, Chong SH, Lee HS, Choe H., Pharmacol Res. November 1, 2009; 60 (5): 429-37.
	Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors., Mosley CA, Myers SJ, Murray EE, Santangelo R, Tahirovic YA, Kurtkaya N, Mullasseril P, Yuan H, Lyuboslavsky P, Le P, Wilson LJ, Yepes M, Dingledine R, Traynelis SF, Liotta DC., Bioorg Med Chem. September 1, 2009; 17 (17): 6463-80.
	A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels., Gustina AS, Trudeau MC., Proc Natl Acad Sci U S A. August 4, 2009; 106 (31): 13082-7.
	The role of hERG1 K+ channels and a functional link between hERG1 K+ channels and SDF-1 in acute leukemic cell migration., Li H, Du YM, Guo L, Jie S, Zhang S, Du W, Chen X, Liu W, Fan L, Zhu J, Zou A, Huang S., Exp Cell Res. August 1, 2009; 315 (13): 2256-64.
	Characterization of novel KCNH2 mutations in type 2 long QT syndrome manifesting as seizures., Keller DI, Grenier J, Christé G, Dubouloz F, Osswald S, Brink M, Ficker E, Chahine M., Can J Cardiol. August 1, 2009; 25 (8): 455-62.
	Differential modulation of cardiac potassium channels by Grb adaptor proteins., Ureche ON, Ureche L, Henrion U, Strutz-Seebohm N, Bundis F, Steinmeyer K, Lang F, Seebohm G., Biochem Biophys Res Commun. June 19, 2009; 384 (1): 28-31.
	The evolutionarily conserved residue A653 plays a key role in HERG channel closing., Stepanovic SZ, Potet F, Petersen CI, Smith JA, Meiler J, Balser JR, Kupershmidt S., J Physiol. June 1, 2009; 587 (Pt 11): 2555-66.
	Block of HERG k channel by classic histamine h(1) receptor antagonist chlorpheniramine., Hong HK, Jo SH., Korean J Physiol Pharmacol. June 1, 2009; 13 (3): 215-20.
	Biophysical properties of zebrafish ether-à-go-go related gene potassium channels., Scholz EP, Niemer N, Hassel D, Zitron E, Bürgers HF, Bloehs R, Seyler C, Scherer D, Thomas D, Kathöfer S, Katus HA, Rottbauer WA, Karle CA., Biochem Biophys Res Commun. April 3, 2009; 381 (2): 159-64.
	Participation of HERG channel cytoplasmic structures on regulation by the G protein-coupled TRH receptor., Alonso-Ron C, Barros F, Manso DG, Gómez-Varela D, Miranda P, Carretero L, Domínguez P, de la Peña P., Pflugers Arch. April 1, 2009; 457 (6): 1237-52.
	Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels., Lee SY, Banerjee A, MacKinnon R., PLoS Biol. March 3, 2009; 7 (3): e47.
	Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro., Fanoe S, Jensen GB, Sjøgren P, Korsgaard MP, Grunnet M., Br J Clin Pharmacol. February 1, 2009; 67 (2): 172-9.
	Discovery of a novel activator of KCNQ1-KCNE1 K channel complexes., Mruk K, Kobertz WR., PLoS One. January 1, 2009; 4 (1): e4236.
	Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents., Scherer D, Hassel D, Bloehs R, Zitron E, von Löwenstern K, Seyler C, Thomas D, Konrad F, Bürgers HF, Seemann G, Rottbauer W, Katus HA, Karle CA, Scholz EP., Br J Pharmacol. January 1, 2009; 156 (2): 226-36.
	The effects of chiral isolates of methadone on the cardiac potassium channel IKr., Lin C, Somberg T, Molnar J, Somberg J., Cardiology. January 1, 2009; 113 (1): 59-65.
	Extracellular potassium dependency of block of HERG by quinidine and cisapride is primarily determined by the permeant ion and not by inactivation., Barrows B, Cheung K, Bialobrzeski T, Foster J, Schulze J, Miller A., Channels (Austin). January 1, 2009; 3 (4): 239-48.
	Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration., Kim YJ, Hong HK, Lee HS, Moh SH, Park JC, Jo SH, Choe H., J Cardiovasc Pharmacol. December 1, 2008; 52 (6): 485-93.
	Molecular determinants of hERG channel block by terfenadine and cisapride., Kamiya K, Niwa R, Morishima M, Honjo H, Sanguinetti MC., J Pharmacol Sci. November 1, 2008; 108 (3): 301-7.
	A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncope., Christé G, Thériault O, Chahine M, Millat G, Rodriguez-Lafrasse C, Rousson R, Deschênes I, Ficker E, Chevalier P., Heart Rhythm. November 1, 2008; 5 (11): 1577-86.
	Cardiac ion channel gene mutations in sudden infant death syndrome., Otagiri T, Kijima K, Osawa M, Ishii K, Makita N, Matoba R, Umetsu K, Hayasaka K., Pediatr Res. November 1, 2008; 64 (5): 482-7.
	[Analysis and analyzing mechanisms of HERG channel kinetics]., Wang X, Li L, Zou A, Tu D, Liao Y., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. October 1, 2008; 25 (5): 1068-73.
	A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels., Abdel-Mottaleb Y, Corzo G, Martin-Eauclaire MF, Satake H, Céard B, Peigneur S, Nambaru P, Bougis PE, Possani LD, Tytgat J., Biochem Pharmacol. September 15, 2008; 76 (6): 805-15.
	Clomipramine block of the hERG K+ channel: accessibility to F656 and Y652., Jo SH, Hong HK, Chong SH, Won KH, Jung SJ, Choe H., Eur J Pharmacol. September 11, 2008; 592 (1-3): 19-25.
	Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current., Larsen AP, Olesen SP, Grunnet M, Jespersen T., Pflugers Arch. September 1, 2008; 456 (6): 1137-48.
	Blockade of the human ether-a-go-go-related gene potassium channel by ketanserin., Tu DN, Zou AR, Liao YH, Du YM, Wang XP, Li L., Sheng Li Xue Bao. August 25, 2008; 60 (4): 525-34.
	Electropharmacological properties of telmisartan in blocking hKv1.5 and HERG potassium channels expressed on Xenopus laevis oocytes., Tu DN, Liao YH, Zou AR, Du YM, Run Q, Wang XP, Li L., Acta Pharmacol Sin. August 1, 2008; 29 (8): 913-22.
	[The persistent expression of HERG channel in Xenopus oocyte and alteration of current]., Wang XP, Li L, Zou AR, Tu DN, Liao YH., Zhongguo Ying Yong Sheng Li Xue Za Zhi. August 1, 2008; 24 (3): 329-33.
	Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin., Scherer D, von Löwenstern K, Zitron E, Scholz EP, Bloehs R, Kathöfer S, Thomas D, Bauer A, Katus HA, Karle CA, Kiesecker C., Naunyn Schmiedebergs Arch Pharmacol. July 1, 2008; 378 (1): 73-83.
	OdK2, a Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae., Abdel-Mottaleb Y, Vandendriessche T, Clynen E, Landuyt B, Jalali A, Vatanpour H, Schoofs L, Tytgat J., Toxicon. June 15, 2008; 51 (8): 1424-30.
	C101, a novel 4-amino-piperidine derivative selectively blocks N-type calcium channels., Zhang S, Su R, Zhang C, Liu X, Li J, Zheng J., Eur J Pharmacol. June 10, 2008; 587 (1-3): 42-7.
	Topological mapping of the asymmetric drug binding to the human ether-à-go-go-related gene product (HERG) potassium channel by use of tandem dimers., Myokai T, Ryu S, Shimizu H, Oiki S., Mol Pharmacol. June 1, 2008; 73 (6): 1643-51.
	Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)., Xu X, Recanatini M, Roberti M, Tseng GN., Mol Pharmacol. June 1, 2008; 73 (6): 1709-21.
	Thermodynamic and kinetic properties of amino-terminal and S4-S5 loop HERG channel mutants under steady-state conditions., Alonso-Ron C, de la Peña P, Miranda P, Domínguez P, Barros F., Biophys J. May 15, 2008; 94 (10): 3893-911.
	Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels., Cuypers E, Abdel-Mottaleb Y, Kopljar I, Rainier JD, Raes AL, Snyders DJ, Tytgat J., Toxicon. May 1, 2008; 51 (6): 974-83.
	An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels., Ma Z, Wong KY, Horrigan FT., J Gen Physiol. May 1, 2008; 131 (5): 483-502.
	A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator., Perry M, Sanguinetti MC., Mol Pharmacol. April 1, 2008; 73 (4): 1044-51.
	Structural basis for ether-a-go-go-related gene K+ channel subtype-dependent activation by niflumic acid., Fernandez D, Sargent J, Sachse FB, Sanguinetti MC., Mol Pharmacol. April 1, 2008; 73 (4): 1159-67.
	Modulation of voltage-gated Na+ and K+ channels by pumiliotoxin 251D: a "joint venture" alkaloid from arthropods and amphibians., Vandendriessche T, Abdel-Mottaleb Y, Maertens C, Cuypers E, Sudau A, Nubbemeyer U, Mebs D, Tytgat J., Toxicon. March 1, 2008; 51 (3): 334-44.
	Endoplasmic reticulum retention and rescue by heteromeric assembly regulate human ERG 1a/1b surface channel composition., Phartiyal P, Sale H, Jones EM, Robertson GA., J Biol Chem. February 15, 2008; 283 (7): 3702-7.
	Chlorthalidone inhibits the KvLQT1 potassium current in guinea-pig ventricular myocytes and oocytes from Xenopus laevis., Mancilla-Simbro C, López A, Martinez-Morales E, Soto-Perez-de-Celis E, Millan-PerezPeña L, Tsushima R, Salinas-Stefanon EM., Br J Pharmacol. February 1, 2008; 153 (3): 448-58.
	Protriptyline block of the human ether-à-go-go-related gene (HERG) K+ channel., Jo SH, Hong HK, Chong SH, Choe H., Life Sci. January 30, 2008; 82 (5-6): 331-40.
	Extracellular acidification and hyperkalemia induce changes in HERG inhibition by ibutilide., Lin C, Ke X, Ranade V, Somberg J., Cardiology. January 1, 2008; 110 (3): 209-16.
	The additive effects of the active component of grapefruit juice (naringenin) and antiarrhythmic drugs on HERG inhibition., Lin C, Ke X, Ranade V, Somberg J., Cardiology. January 1, 2008; 110 (3): 145-52.
	Cardiac sodium channel gene variants and sudden cardiac death in women., Albert CM, Nam EG, Rimm EB, Jin HW, Hajjar RJ, Hunter DJ, MacRae CA, Ellinor PT., Circulation. January 1, 2008; 117 (1): 16-23.
	Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels., Piper DR, Rupp J, Sachse FB, Sanguinetti MC, Tristani-Firouzi M., Cell Physiol Biochem. January 1, 2008; 21 (1-3): 37-46.
	Biophysical characterization of the short QT mutation hERG-N588K reveals a mixed gain-and loss-of-function., Grunnet M, Diness TG, Hansen RS, Olesen SP., Cell Physiol Biochem. January 1, 2008; 22 (5-6): 611-24.
	A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating., Brown S, Sonntag DP, Sanguinetti MC., Cell Physiol Biochem. January 1, 2008; 22 (5-6): 601-10.

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