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Summary Expression Phenotypes Gene Literature (45) GO Terms (2) Nucleotides (153) Proteins (55) Interactants (189) Wiki
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Papers associated with orc2



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Role for a Xenopus Orc2-related protein in controlling DNA replication., Carpenter PB, Mueller PR, Dunphy WG., Nature. January 25, 1996; 379 (6563): 357-60.

A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle., Hua XH, Yan H, Newport J., J Cell Biol. April 7, 1997; 137 (1): 183-92.            

Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes., Pak DT, Pflumm M, Chesnokov I, Huang DW, Kellum R, Marr J, Romanowski P, Botchan MR., Cell. October 31, 1997; 91 (3): 311-23.

Protein kinase A is required for chromosomal DNA replication., Costanzo V, Avvedimento EV, Gottesman ME, Gautier J, Grieco D., Curr Biol. August 26, 1999; 9 (16): 903-6.

Cyclin A-dependent kinase activity affects chromatin binding of ORC, Cdc6, and MCM in egg extracts of Xenopus laevis., Findeisen M, El-Denary M, Kapitza T, Graf R, Strausfeld U., Eur J Biochem. September 1, 1999; 264 (2): 415-26.

The roles of the MCM, ORC, and Cdc6 proteins in determining the replication competence of chromatin in quiescent cells., Madine MA, Swietlik M, Pelizon C, Romanowski P, Mills AD, Laskey RA., J Struct Biol. April 1, 2000; 129 (2-3): 198-210.

Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals., Natale DA, Li CJ, Sun WH, DePamphilis ML., EMBO J. June 1, 2000; 19 (11): 2728-38.

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis., Méndez J, Stillman B., Mol Cell Biol. November 1, 2000; 20 (22): 8602-12.

Identification and characterization of the human ORC6 homolog., Dhar SK, Dutta A., J Biol Chem. November 10, 2000; 275 (45): 34983-8.

Aberrant replication timing induces defective chromosome condensation in Drosophila ORC2 mutants., Loupart ML, Krause SA, Heck MS., Curr Biol. December 1, 2000; 10 (24): 1547-56.

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin., Tada S, Li A, Maiorano D, Méchali M, Blow JJ., Nat Cell Biol. February 1, 2001; 3 (2): 107-13.

Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication., Furstenthal L, Kaiser BK, Swanson C, Jackson PK., J Cell Biol. March 19, 2001; 152 (6): 1267-78.                    

The binding of ORC2 to chromatin from terminally differentiated cells., Xu H, Lu ZH, Leno GH., Exp Cell Res. April 1, 2002; 274 (2): 334-41.

The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication., Van Hatten RA, Tutter AV, Holway AH, Khederian AM, Walter JC, Michael WM., J Cell Biol. November 25, 2002; 159 (4): 541-7.          

Characterization of a novel origin recognition complex-like complex: implications for DNA recognition, cell cycle control, and locus-specific gene amplification., Mohammad M, York RD, Hommel J, Kapler GM., Mol Cell Biol. July 1, 2003; 23 (14): 5005-17.

DNA damage-induced replication arrest in Xenopus egg extracts., Stokes MP, Michael WM., J Cell Biol. October 27, 2003; 163 (2): 245-55.                

The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation., Oehlmann M, Score AJ, Blow JJ., J Cell Biol. April 26, 2004; 165 (2): 181-90.                  

A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes., Grishina I, Lattes B., Cell Cycle. August 1, 2005; 4 (8): 1120-6.

ORC is necessary at the interphase-to-mitosis transition to recruit cdc2 kinase and disassemble RPA foci., Cuvier O, Lutzmann M, Méchali M., Curr Biol. March 7, 2006; 16 (5): 516-23.

The N-terminal noncatalytic region of Xenopus RecQ4 is required for chromatin binding of DNA polymerase alpha in the initiation of DNA replication., Matsuno K, Kumano M, Kubota Y, Hashimoto Y, Takisawa H., Mol Cell Biol. July 1, 2006; 26 (13): 4843-52.                

ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and replication licensing., Gillespie PJ, Khoudoli GA, Stewart G, Swedlow JR, Blow JJ., Curr Biol. October 9, 2007; 17 (19): 1657-62.        

Cdc7-Drf1 kinase links chromosome cohesion to the initiation of DNA replication in Xenopus egg extracts., Takahashi TS, Basu A, Bermudez V, Hurwitz J, Walter JC., Genes Dev. July 15, 2008; 22 (14): 1894-905.            

The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication., Aparicio T, Guillou E, Coloma J, Montoya G, Méndez J., Nucleic Acids Res. April 1, 2009; 37 (7): 2087-95.              

Origin-dependent initiation of DNA replication within telomeric sequences., Kurth I, Gautier J., Nucleic Acids Res. January 1, 2010; 38 (2): 467-76.          

Treslin collaborates with TopBP1 in triggering the initiation of DNA replication., Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Cell. February 5, 2010; 140 (3): 349-59.                        

Continued primer synthesis at stalled replication forks contributes to checkpoint activation., Van C, Yan S, Michael WM, Waga S, Cimprich KA., J Cell Biol. April 19, 2010; 189 (2): 233-46.              

The midblastula transition defines the onset of Y RNA-dependent DNA replication in Xenopus laevis., Collart C, Christov CP, Smith JC, Krude T., Mol Cell Biol. September 1, 2011; 31 (18): 3857-70.

Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos., Kisielewska J, Blow JJ., Development. January 1, 2012; 139 (1): 63-74.              

Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation., Gambus A, Blow JJ., Cell Cycle. April 15, 2013; 12 (8): 1225-32.                

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks., Lee J, Dunphy WG., Mol Biol Cell. May 1, 2013; 24 (9): 1343-53.          

Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts., Taylor EM, Bonsu NM, Price RJ, Lindsay HD., Nucleic Acids Res. September 1, 2013; 41 (16): 7725-37.              

Tight Chk1 Levels Control Replication Cluster Activation in Xenopus., Platel M, Goldar A, Wiggins JM, Barbosa P, Libeau P, Priam P, Narassimprakash H, Grodzenski X, Marheineke K., PLoS One. June 5, 2015; 10 (6): e0129090.                    

MutSα maintains the mismatch repair capability by inhibiting PCNA unloading., Kawasoe Y, Tsurimoto T, Nakagawa T, Masukata H, Takahashi TS., Elife. July 12, 2016; 5                                     

Xenopus Mcm10 is a CDK-substrate required for replication fork stability., Chadha GS, Gambus A, Gillespie PJ, Blow JJ., Cell Cycle. August 17, 2016; 15 (16): 2183-2195.            

Rethinking origin licensing., Bell SP., Elife. January 19, 2017; 6   

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines., Gardner NJ, Gillespie PJ, Carrington JT, Shanks EJ, McElroy SP, Haagensen EJ, Frearson JA, Woodland A, Blow JJ., Cell Chem Biol. August 17, 2017; 24 (8): 981-992.e4.                        

MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication., Kumagai A, Dunphy WG., Mol Biol Cell. November 1, 2017; 28 (22): 2998-3012.              

Suppression of targeting of Dbf4-dependent kinase to pre-replicative complex in G0 nuclei., Okada T, Okabe G, Tak YS, Mimura S, Takisawa H, Kubota Y., Genes Cells. February 1, 2018; 23 (2): 94-104.

Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts., Larsen NB, Gao AO, Sparks JL, Gallina I, Wu RA, Mann M, Räschle M, Walter JC, Duxin JP., Mol Cell. February 7, 2019; 73 (3): 574-588.e7.                

RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR., Lyu K, Kumagai A, Dunphy WG., Cell Cycle. April 1, 2019; 18 (8): 898-913.              

Inhibition of DNA replication initiation by silver nanoclusters., Tao Y, Aparicio T, Li M, Leong KW, Zha S, Gautier J., Nucleic Acids Res. May 21, 2021; 49 (9): 5074-5083.                        

Polo-like kinase 1 (Plk1) regulates DNA replication origin firing and interacts with Rif1 in Xenopus., Ciardo D, Haccard O, Narassimprakash H, Cornu D, Guerrera IC, Goldar A, Marheineke K., Nucleic Acids Res. September 27, 2021; 49 (17): 9851-9869.                                        

Differential nuclear import sets the timing of protein access to the embryonic genome., Nguyen T, Costa EJ, Deibert T, Reyes J, Keber FC, Tomschik M, Stadlmeier M, Gupta M, Kumar CK, Cruz ER, Amodeo A, Gatlin JC, Wühr M., Nat Commun. October 6, 2022; 13 (1): 5887.                                  

Rif1 restrains the rate of replication origin firing in Xenopus laevis., Haccard O, Ciardo D, Narrissamprakash H, Bronchain O, Kumagai A, Dunphy WG, Goldar A, Marheineke K., Commun Biol. July 29, 2023; 6 (1): 788.                                

Resection of DNA double-strand breaks activates Mre11-Rad50-Nbs1- and Rad9-Hus1-Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts., Tatsukawa K, Sakamoto R, Kawasoe Y, Kubota Y, Tsurimoto T, Takahashi TS, Ohashi E., Nucleic Acids Res. April 12, 2024; 52 (6): 3146-3163.                  

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