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Summary Expression Phenotypes Gene Literature (72) GO Terms (5) Nucleotides (86) Proteins (38) Interactants (137) Wiki

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19th International Xenopus Conference Meeting Report: Latest developments and future perspectives., Zhou C, Kulkarni S., Dev Dyn. February 1, 2024; 253 (2): 272-276.

Adipose tissue derived stem cell secretome induces motor and histological gains after complete spinal cord injury in Xenopus laevis and mice., Assunção-Silva RC, Pinho A, Cibrão JR, Pereira IM, Monteiro S, Silva NA, Campos J, Rebelo AL, Schlosser G, Pinto L, Pandit A, Salgado AJ., J Tissue Eng. January 1, 2024; 15 20417314231203824.              

Critical contribution of the intracellular C-terminal region to TRESK channel activity is revealed by the epithelial Na+ current ratio method., Debreczeni D, Baukál D, Pergel E, Veres I, Czirják G., J Biol Chem. June 1, 2023; 299 (6): 104737.                        

Structure of a eukaryotic cholinephosphotransferase-1 reveals mechanisms of substrate recognition and catalysis., Wang L, Zhou M., Nat Commun. May 13, 2023; 14 (1): 2753.

Do Amino Acid Antiporters Have Asymmetric Substrate Specificity?, Gauthier-Coles G, Fairweather SJ, Bröer A, Bröer S., Biomolecules. February 6, 2023; 13 (2):                 

Flux coupling, not specificity, shapes the transport and phylogeny of SLC6 glycine transporters., Le Guellec B, Rousseau F, Bied M, Supplisson S., Proc Natl Acad Sci U S A. October 11, 2022; 119 (41): e2205874119.                                              

Human Melanocortin-2 Receptor: Identifying a Role for Residues in the TM4, EC2, and TM5 Domains in Activation and Trafficking as a Result of Co-Expression with the Accessory Protein, Mrap1 in Chinese Hamster Ovary Cells., Davis PV, Shaughnessy CA, Dores RM., Biomolecules. October 4, 2022; 12 (10):

Bupivacaine as a euthanasia agent for African Clawed Frogs (Xenopus laevis)., Navarro K, Jampachaisri K, Chu D, Pacharinsak C., PLoS One. January 1, 2022; 17 (12): e0279331.      

Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex., Zhang Y, Li S, Zeng C, Huang G, Zhu X, Wang Q, Wang K, Zhou Q, Yan C, Zhang W, Yang G, Liu M, Tao Q, Tao Q, Lei J, Shi Y., Cell Res. June 1, 2020; 30 (6): 532-540.                                

Identifying Common Features in the Activation of Melanocortin-2 Receptors: Studies on the Xenopus tropicalis Melanocortin-2 Receptor., Davis PE, Wilkinson EC, Dores RM., Int J Mol Sci. August 26, 2019; 20 (17):           

Functional analysis of a triplet deletion in the gene encoding the sodium glucose transporter 3, a potential risk factor for ADHD., Schäfer N, Friedrich M, Jørgensen ME, Kollert S, Koepsell H, Wischmeyer E, Lesch KP, Geiger D, Döring F., PLoS One. October 4, 2018; 13 (10): e0205109.                

Effects of trimethoprim-sulfadiazine and detomidine on the function of equine Kv 11.1 channels in a two-electrode voltage-clamp (TEVC) oocyte model., Trachsel DS, Tejada MA, Groesfjeld Christensen V, Pedersen PJ, Kanters JK, Buhl R, Calloe K, Klaerke DA., J Vet Pharmacol Ther. August 1, 2018; 41 (4): 536-545.

Point mutation of a conserved aspartate, D69, in the muscarinic M 2  receptor does not modify voltage-sensitive agonist potency., Ågren R, Sahlholm K, Nilsson J, Århem P., Biochem Biophys Res Commun. January 29, 2018; 496 (1): 101-104.  

Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ -independent manner and an amino acid residue at the slide helix governs the activation., Chen IS, Tateyama M, Fukata Y, Uesugi M, Kubo Y., J Physiol. September 1, 2017; 595 (17): 5895-5912.

Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance., Mulinta R, Yao SYM, Ng AML, Cass CE, Young JD., J Biol Chem. June 9, 2017; 292 (23): 9505-9522.                    

Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating., Gonzalez-Perez V, Xia XM, Lingle CJ., Nat Commun. September 21, 2015; 6 8341.        

The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters., Aseervatham J, Tran L, Machaca K, Boudker O., PLoS One. September 1, 2015; 10 (9): e0136779.            

The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes., Shibano T, Mamada H, Hakuno F, Takahashi S, Taira M., PLoS One. May 6, 2015; 10 (5): e0127271.                                

Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis., Kobayashi Y, Hamamoto A, Hirayama T, Saito Y., Gen Comp Endocrinol. February 1, 2015; 212 114-23.                

A novel PKD2L1 C-terminal domain critical for trimerization and channel function., Zheng W, Hussein S, Yang J, Huang J, Zhang F, Hernandez-Anzaldo S, Fernandez-Patron C, Cao Y, Cao Y, Zeng H, Tang J, Chen XZ., Sci Rep. January 12, 2015; 5 9460.              

The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production., Zhang R, Wang K, Lv W, Yu W, Xie S, Xu K, Schwarz W, Xiong S, Sun B., Biochim Biophys Acta. April 1, 2014; 1838 (4): 1088-95.              

Both transmembrane domains of BK β1 subunits are essential to confer the normal phenotype of β1-containing BK channels., Kuntamallappanavar G, Toro L, Dopico AM., PLoS One. January 1, 2014; 9 (10): e109306.          

The SLC16 gene family - structure, role and regulation in health and disease., Halestrap AP., Mol Aspects Med. January 1, 2013; 34 (2-3): 337-49.

Arg188 in rice sucrose transporter OsSUT1 is crucial for substrate transport., Sun Y, Ward JM., BMC Biochem. November 21, 2012; 13 26.          

Effect of simultaneously replacing putative TM6 and TM12 of human NBCe1-A with those from NBCn1 on surface abundance in Xenopus oocytes., Chen LM, Qin X, Moss FJ, Liu Y, Boron WF., J Membr Biol. March 1, 2012; 245 (3): 131-40.

The intracellular amino terminus plays a dominant role in desensitization of ATP-gated P2X receptor ion channels., Allsopp RC, Evans RJ., J Biol Chem. December 30, 2011; 286 (52): 44691-701.            

The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein., Ovens MJ, Manoharan C, Wilson MC, Murray CM, Halestrap AP., Biochem J. October 15, 2010; 431 (2): 217-25.              

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10., Ovens MJ, Davies AJ, Wilson MC, Murray CM, Halestrap AP., Biochem J. January 15, 2010; 425 (3): 523-30.              

Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore., Alexander C, Ivetac A, Liu X, Norimatsu Y, Serrano JR, Landstrom A, Sansom M, Dawson DC., Biochemistry. October 27, 2009; 48 (42): 10078-88.                

Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptors., Asatryan L, Popova M, Woodward JJ, King BF, Alkana RL, Davies DL., Neuropharmacology. October 1, 2008; 55 (5): 835-43.

Structural signatures and membrane helix 4 in GLUT1: inferences from human blood-brain glucose transport mutants., Pascual JM, Wang D, Yang R, Shi L, Yang H, De Vivo DC., J Biol Chem. June 13, 2008; 283 (24): 16732-42.

Presence of aquaporin and V-ATPase on the contractile vacuole of Amoeba proteus., Nishihara E, Yokota E, Tazaki A, Orii H, Katsuhara M, Kataoka K, Igarashi H, Moriyama Y, Shimmen T, Sonobe S., Biol Cell. March 1, 2008; 100 (3): 179-88.

The Xenopus FcR family demonstrates continually high diversification of paired receptors in vertebrate evolution., Guselnikov SV, Ramanayake T, Erilova AY, Mechetina LV, Najakshin AM, Robert J, Taranin AV., BMC Evol Biol. February 8, 2008; 8 148.                

A conductive pathway generated from fragments of the human red cell anion exchanger AE1., Parker MD, Young MT, Daly CM, Meech RW, Boron WF, Tanner MJ., J Physiol. May 15, 2007; 581 (Pt 1): 33-50.

Ivermectin Interaction with transmembrane helices reveals widespread rearrangements during opening of P2X receptor channels., Silberberg SD, Li M, Swartz KJ., Neuron. April 19, 2007; 54 (2): 263-74.

Specific mutations in transmembrane helix 8 of human concentrative Na+/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling., Slugoski MD, Loewen SK, Ng AM, Smith KM, Yao SY, Karpinski E, Cass CE, Baldwin SA, Young JD., Biochemistry. February 13, 2007; 46 (6): 1684-93.

Recent progress in structure-function analyses of Nramp proton-dependent metal-ion transporters., Courville P, Chaloupka R, Cellier MF., Biochem Cell Biol. December 1, 2006; 84 (6): 960-78.

Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels., Silberberg SD, Chang TH, Swartz KJ., J Gen Physiol. April 1, 2005; 125 (4): 347-59.                

Mutational analysis of the alpha-1 repeat of the cardiac Na(+)-Ca2+ exchanger., Ottolia M, Nicoll DA, Philipson KD., J Biol Chem. January 14, 2005; 280 (2): 1061-9.

The amino acid transporter asc-1 is not involved in cystinuria., Pineda M, Font M, Bassi MT, Manzoni M, Borsani G, Marigo V, Fernández E, Río RM, Purroy J, Zorzano A, Nunes V, Palacín M., Kidney Int. October 1, 2004; 66 (4): 1453-64.

Cross-linking of glycine receptor transmembrane segments two and three alters coupling of ligand binding with channel opening., Lobo IA, Trudell JR, Harris RA., J Neurochem. August 1, 2004; 90 (4): 962-9.

Cation stoichiometry and cation pathway in the Na,K-ATPase and nongastric H,K-ATPase., Horisberger JD, Guennoun S, Burnay M, Geering K., Ann N Y Acad Sci. April 1, 2003; 986 127-32.

Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides., Reimann F, Dabrowski M, Jones P, Gribble FM, Ashcroft FM., J Physiol. February 15, 2003; 547 (Pt 1): 159-68.

Cooperativity and flexibility of cystic fibrosis transmembrane conductance regulator transmembrane segments participate in membrane localization of a charged residue., Carveth K, Buck T, Anthony V, Skach WR., J Biol Chem. October 18, 2002; 277 (42): 39507-14.

Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation., Yao SY, Ng AM, Vickers MF, Sundaram M, Cass CE, Baldwin SA, Young JD., J Biol Chem. July 12, 2002; 277 (28): 24938-48.

Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains., Matsuo H, Kanai Y, Kim JY, Chairoungdua A, Kim DK, Inatomi J, Shigeta Y, Ishimine H, Chaekuntode S, Tachampa K, Choi HW, Babu E, Fukuda J, Endou H., J Biol Chem. June 7, 2002; 277 (23): 21017-26.

Characterisation and cloning of a Na(+)-dependent broad-specificity neutral amino acid transporter from NBL-1 cells: a novel member of the ASC/B(0) transporter family., Pollard M, Meredith D, McGivan JD., Biochim Biophys Acta. April 12, 2002; 1561 (2): 202-8.

The oxidant thimerosal modulates gating behavior of KCNQ1 by interaction with the channel outer shell., Kerst G, Brousos H, Schreiber R, Nitschke R, Hug MJ, Greger R, Bleich M., J Membr Biol. March 15, 2002; 186 (2): 89-100.

Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain., Chairoungdua A, Kanai Y, Matsuo H, Inatomi J, Kim DK, Endou H., J Biol Chem. December 28, 2001; 276 (52): 49390-9.

A disulfide bond is required for functional assembly of NCX1 from complementary fragments., Qiu Z, Chen J, Nicoll DA, Philipson KD., Biochem Biophys Res Commun. October 5, 2001; 287 (4): 825-8.

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