Papers associated with kcnh2

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	PIKfyve sensitivity of hERG channels., Pakladok T, Almilaji A, Munoz C, Alesutan I, Lang F., Cell Physiol Biochem. January 1, 2013; 31 (6): 785-94.
	Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1., Aidery P, Kisselbach J, Schweizer PA, Becker R, Katus HA, Thomas D., Gene. December 10, 2012; 511 (1): 26-33.
	A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins., Peigneur S, Béress L, Möller C, Marí F, Forssmann WG, Tytgat J., FASEB J. December 1, 2012; 26 (12): 5141-51.
	Kcnh1 voltage-gated potassium channels are essential for early zebrafish development., Stengel R, Rivera-Milla E, Sahoo N, Ebert C, Bollig F, Heinemann SH, Schönherr R, Englert C., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.
	Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels., Twiner MJ, Doucette GJ, Rasky A, Huang XP, Roth BL, Sanguinetti MC., Chem Res Toxicol. September 17, 2012; 25 (9): 1975-84.
	Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule., Garg V, Sachse FB, Sanguinetti MC., J Gen Physiol. September 1, 2012; 140 (3): 307-24.
	Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels., Tan PS, Perry MD, Ng CA, Vandenberg JI, Hill AP., J Gen Physiol. September 1, 2012; 140 (3): 293-306.
	Coexisting mutations/polymorphisms of the long QT syndrome genes in patients with repaired Tetralogy of Fallot are associated with the risks of life-threatening events., Chiu SN, Wu MH, Su MJ, Wang JK, Lin MT, Chang CC, Hsu HW, Shen CT, Thériault O, Chahine M., Hum Genet. August 1, 2012; 131 (8): 1295-304.
	Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A., Kulzer M, Seyler C, Welke F, Scherer D, Xynogalos P, Scholz EP, Thomas D, Becker R, Karle CA, Katus HA, Zitron E., Biochem Biophys Res Commun. July 27, 2012; 424 (2): 315-20.
	Acute alteration of cardiac ECG, action potential, I(Kr) and the human ether-a-go-go-related gene (hERG) K+ channel by PCB 126 and PCB 77., Park MH, Park WS, Jo SH., Toxicol Appl Pharmacol. July 1, 2012; 262 (1): 60-9.
	Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis., Van Slyke AC, Cheng YM, Mafi P, Allard CR, Hull CM, Shi YP, Claydon TW., Am J Physiol Cell Physiol. June 15, 2012; 302 (12): C1797-806.
	18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels., Du YM, Xia CK, Zhao N, Dong Q, Lei M, Xia JH., Acta Pharmacol Sin. June 1, 2012; 33 (6): 752-60.
	Identification and functional characterization of the novel human ether-a-go-go-related gene (hERG) R744P mutant associated with hereditary long QT syndrome 2., Aidery P, Kisselbach J, Gaspar H, Baldea I, Schweizer PA, Becker R, Katus HA, Thomas D., Biochem Biophys Res Commun. February 24, 2012; 418 (4): 830-5.
	Pharmacophore modeling for hERG channel facilitation., Yamakawa Y, Furutani K, Inanobe A, Ohno Y, Kurachi Y., Biochem Biophys Res Commun. February 3, 2012; 418 (1): 161-6.
	Stimulation of HERG channel activity by β-catenin., Munoz C, Saxena A, Pakladok T, Bogatikov E, Wilmes J, Seebohm G, Föller M, Lang F., PLoS One. January 1, 2012; 7 (8): e43353.
	A molecular switch driving inactivation in the cardiac K+ channel HERG., Köpfer DA, Hahn U, Ohmert I, Vriend G, Pongs O, de Groot BL, Zachariae U., PLoS One. January 1, 2012; 7 (7): e41023.
	A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents., Furutani K, Yamakawa Y, Inanobe A, Iwata M, Ohno Y, Kurachi Y., Biochem Biophys Res Commun. November 11, 2011; 415 (1): 141-6.
	Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway., Ferrer T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E, Tristani-Firouzi M., J Biol Chem. November 11, 2011; 286 (45): 39091-9.
	Strong activation of ether-à-go-go-related gene 1 K+ channel isoforms by NS1643 in human embryonic kidney 293 and Chinese hamster ovary cells., Schuster AM, Glassmeier G, Bauer CK., Mol Pharmacol. November 1, 2011; 80 (5): 930-42.
	Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide., Garg V, Stary-Weinzinger A, Sachse F, Sanguinetti MC., Mol Pharmacol. October 1, 2011; 80 (4): 630-7.
	Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration., Lee BH, Lee SH, Chu D, Hyun JW, Choe H, Choi BH, Jo SH., Acta Pharmacol Sin. September 1, 2011; 32 (9): 1128-37.
	Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells., Crottès D, Martial S, Rapetti-Mauss R, Pisani DF, Loriol C, Pellissier B, Martin P, Chevet E, Borgese F, Soriani O., J Biol Chem. August 12, 2011; 286 (32): 27947-58.
	Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant., Es-Salah-Lamoureux Z, Xiong PY, Goodchild SJ, Ahern CA, Fedida D., Biophys J. August 3, 2011; 101 (3): 662-70.
	Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction., Choi SH, Shin TJ, Hwang SH, Lee BH, Kang J, Kim HJ, Jo SH, Choe H, Nah SY., Eur J Pharmacol. August 1, 2011; 663 (1-3): 59-67.
	Functional characterization of the LQT2-causing mutation R582C and the associated voltage-dependent fluorescence signal., Fougere RR, Es-Salah-Lamoureux Z, Rezazadeh S, Eldstrom J, Fedida D., Heart Rhythm. August 1, 2011; 8 (8): 1273-80.
	A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties., Peigneur S, Billen B, Derua R, Waelkens E, Debaveye S, Béress L, Tytgat J., Biochem Pharmacol. July 1, 2011; 82 (1): 81-90.
	Differential effects of ginsenoside metabolites on HERG k channel currents., Choi SH, Shin TJ, Hwang SH, Lee BH, Kang J, Kim HJ, Oh JW, Bae CS, Lee SH, Nah SY., J Ginseng Res. June 1, 2011; 35 (2): 191-9.
	Demonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channel., de la Peña P, Alonso-Ron C, Machín A, Fernández-Trillo J, Carretero L, Domínguez P, Barros F., J Biol Chem. May 27, 2011; 286 (21): 19065-75.
	hERGAPDbase: a database documenting hERG channel inhibitory potentials and APD-prolongation activities of chemical compounds., Hishigaki H, Kuhara S., Database (Oxford). May 17, 2011; 2011 bar017.
	HERG channel inhibitors in extracts of Coptidis rhizoma., Schramm A, Baburin I, Hering S, Hamburger M., Planta Med. May 1, 2011; 77 (7): 692-7.
	Trapping and dissociation of propafenone derivatives in HERG channels., Windisch A, Timin E, Schwarz T, Stork-Riedler D, Erker T, Ecker G, Hering S., Br J Pharmacol. April 1, 2011; 162 (7): 1542-52.
	hERG potassium channel gating is mediated by N- and C-terminal region interactions., Gustina AS, Trudeau MC., J Gen Physiol. March 1, 2011; 137 (3): 315-25.
	Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function., Jimenez-Vargas JM, Restano-Cassulini R, Quintero-Hernández V, Gurrola GB, Possani LD., Peptides. March 1, 2011; 32 (3): 560-7.
	hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine., Staudacher I, Wang L, Wan X, Obers S, Wenzel W, Tristram F, Koschny R, Staudacher K, Kisselbach J, Koelsch P, Schweizer PA, Katus HA, Ficker E, Thomas D., Naunyn Schmiedebergs Arch Pharmacol. February 1, 2011; 383 (2): 119-39.
	Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643., Grunnet M, Abbruzzese J, Sachse FB, Sanguinetti MC., Mol Pharmacol. January 1, 2011; 79 (1): 1-9.
	A potent potassium channel blocker from Mesobuthus eupeus scorpion venom., Gao B, Peigneur S, Tytgat J, Zhu S., Biochimie. December 1, 2010; 92 (12): 1847-53.
	Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels., Van Slyke AC, Rezazadeh S, Snopkowski M, Shi P, Allard CR, Claydon TW., Biophys J. November 3, 2010; 99 (9): 2841-52.
	Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels., Larsen AP, Bentzen BH, Grunnet M., Br J Pharmacol. October 1, 2010; 161 (3): 614-28.
	Response of i(kr) and HERG currents to the antipsychotics tiapride and sulpiride., Jo SH, Lee SY., Korean J Physiol Pharmacol. October 1, 2010; 14 (5): 305-10.
	Aconitine blocks HERG and Kv1.5 potassium channels., Li Y, Tu D, Xiao H, Du Y, Zou A, Liao Y, Dong S., J Ethnopharmacol. August 19, 2010; 131 (1): 187-95.
	Modification of hERG1 channel gating by Cd2+., Abbruzzese J, Sachse FB, Tristani-Firouzi M, Sanguinetti MC., J Gen Physiol. August 1, 2010; 136 (2): 203-24.
	Regulation of the voltage-insensitive step of HERG activation by extracellular pH., Zhou Q, Bett GC., Am J Physiol Heart Circ Physiol. June 1, 2010; 298 (6): H1710-8.
	Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening., Es-Salah-Lamoureux Z, Fougere R, Xiong PY, Robertson GA, Fedida D., PLoS One. May 3, 2010; 5 (5): e10876.
	Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine., Obers S, Staudacher I, Ficker E, Dennis A, Koschny R, Erdal H, Bloehs R, Kisselbach J, Karle CA, Schweizer PA, Katus HA, Thomas D., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2010; 381 (5): 385-400.
	The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism., Gessner G, Macianskiene R, Starkus JG, Schönherr R, Heinemann SH., Eur J Pharmacol. April 25, 2010; 632 (1-3): 52-9.
	Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling., Ciau-Uitz A, Pinheiro P, Gupta R, Enver T, Patient R., Dev Cell. April 20, 2010; 18 (4): 569-78.
	Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine., Hong HK, Park MH, Lee BH, Jo SH., Biochem Biophys Res Commun. April 9, 2010; 394 (3): 536-41.
	Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652., Xing J, Ma J, Zhang P, Fan X., Eur J Pharmacol. March 25, 2010; 630 (1-3): 1-9.
	Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics., Larsen AP, Olesen SP., PLoS One. February 2, 2010; 5 (2): e9021.
	Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT)., Eckey K, Strutz-Seebohm N, Katz G, Fuhrmann G, Henrion U, Pott L, Linke WA, Arad M, Lang F, Seebohm G., Cell Physiol Biochem. January 1, 2010; 26 (4-5): 503-12.

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