Papers associated with kcnh2

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	Green tea flavonoid epigallocatechin-3-gallate (EGCG) inhibits cardiac hERG potassium channels., Kelemen K, Kiesecker C, Zitron E, Bauer A, Scholz E, Bloehs R, Thomas D, Greten J, Remppis A, Schoels W, Katus HA, Karle CA., Biochem Biophys Res Commun. December 21, 2007; 364 (3): 429-35.
	Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656., Scholz EP, Konrad FM, Weiss DL, Zitron E, Kiesecker C, Bloehs R, Kulzer M, Thomas D, Kathöfer S, Bauer A, Maurer MH, Seemann G, Katus HA, Karle CA., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2007; 376 (4): 275-84.
	Activation gating of hERG potassium channels: S6 glycines are not required as gating hinges., Hardman RM, Stansfeld PJ, Dalibalta S, Sutcliffe MJ, Mitcheson JS., J Biol Chem. November 2, 2007; 282 (44): 31972-81.
	Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656., Scholz EP, Zitron E, Kiesecker C, Thomas D, Kathöfer S, Kreuzer J, Bauer A, Katus HA, Remppis A, Karle CA, Greten J., Nutr Metab Cardiovasc Dis. November 1, 2007; 17 (9): 666-75.
	Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator., Perry M, Sachse FB, Sanguinetti MC., Proc Natl Acad Sci U S A. August 21, 2007; 104 (34): 13827-32.
	State dependent dissociation of HERG channel inhibitors., Stork D, Timin EN, Berjukow S, Huber C, Hohaus A, Auer M, Hering S., Br J Pharmacol. August 1, 2007; 151 (8): 1368-76.
	Activation of ERG2 potassium channels by the diphenylurea NS1643., Elmedyb P, Olesen SP, Grunnet M., Neuropharmacology. August 1, 2007; 53 (2): 283-94.
	Zebrafish model for human long QT syndrome., Arnaout R, Ferrer T, Huisken J, Spitzer K, Stainier DY, Tristani-Firouzi M, Chi NC., Proc Natl Acad Sci U S A. July 3, 2007; 104 (27): 11316-21.
	Verapamil blocks HERG channel by the helix residue Y652 and F656 in the S6 transmembrane domain., Duan JJ, Ma JH, Zhang PH, Wang XP, Zou AR, Tu DN., Acta Pharmacol Sin. July 1, 2007; 28 (7): 959-67.
	Probing the outer mouth structure of the HERG channel with peptide toxin footprinting and molecular modeling., Tseng GN, Sonawane KD, Korolkova YV, Zhang M, Liu J, Grishin EV, Guy HR., Biophys J. May 15, 2007; 92 (10): 3524-40.
	Molecular interaction of droperidol with human ether-a-go-go-related gene channels: prolongation of action potential duration without inducing early afterdepolarization., Schwoerer AP, Blütner C, Brandt S, Binder S, Siebrands CC, Ehmke H, Friederich P., Anesthesiology. May 1, 2007; 106 (5): 967-76.
	Modulation of ERG channels by XE991., Elmedyb P, Calloe K, Schmitt N, Hansen RS, Grunnet M, Olesen SP., Basic Clin Pharmacol Toxicol. May 1, 2007; 100 (5): 316-22.
	Upregulation of KCNE1 induces QT interval prolongation in patients with chronic heart failure., Watanabe E, Yasui K, Kamiya K, Yamaguchi T, Sakuma I, Honjo H, Ozaki Y, Morimoto S, Hishida H, Kodama I., Circ J. April 1, 2007; 71 (4): 471-8.
	Inhibitory effects of coronary vasodilator papaverine on heterologously-expressed HERG currents in Xenopus oocytes., Kim CS, Lee N, Son SJ, Lee KS, Kim HS, Kwak YG, Chae SW, Lee SD, Jeon BH, Park JB., Acta Pharmacol Sin. April 1, 2007; 28 (4): 503-10.
	Maprotiline block of the human ether-a-go-go-related gene (HERG) K+ channel., Jo SH, Hong HK, Jung SJ, Chong SH, Yun JH, Koh YS, Choe H., Arch Pharm Res. April 1, 2007; 30 (4): 453-60.
	Structural requirements of human ether-a-go-go-related gene channels for block by bupivacaine., Siebrands CC, Friederich P., Anesthesiology. March 1, 2007; 106 (3): 523-31.
	The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents., Lin C, Ke X, Cvetanovic I, Ranade V, Somberg J., Cardiology. January 1, 2007; 108 (1): 18-27.
	The effects of quinidine and its chiral isolates on erg-1sm potassium current and correlation with gastrointestinal augmentation., Cvetanovic I, Lin C, Ranade V, Keshavarzian A, Somberg J., Am J Ther. January 1, 2007; 14 (3): 269-76.
	Differences between ion binding to eag and HERG voltage sensors contribute to differential regulation of activation and deactivation gating., Lin MC, Papazian DM., Channels (Austin). January 1, 2007; 1 (6): 429-37.
	Mutational analysis of block and facilitation of HERG current by a class III anti-arrhythmic agent, nifekalant., Hosaka Y, Iwata M, Kamiya N, Yamada M, Kinoshita K, Fukunishi Y, Tsujimae K, Hibino H, Aizawa Y, Inanobe A, Nakamura H, Kurachi Y., Channels (Austin). January 1, 2007; 1 (3): 198-208.
	Linkage between ''disruption of inactivation'' and ''reduction of K+ selectivity'' among hERG mutants in the S5-P linker region., Tseng GN., J Physiol. November 15, 2006; 577 (Pt 1): 459-60; author reply 461-2.
	Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea]., Hansen RS, Diness TG, Christ T, Wettwer E, Ravens U, Olesen SP, Grunnet M., Mol Pharmacol. October 1, 2006; 70 (4): 1319-29.
	Blockade of HERG human K+ channel and IKr of guinea pig cardiomyocytes by prochlorperazine., Kim MD, Eun SY, Jo SH., Eur J Pharmacol. August 21, 2006; 544 (1-3): 82-90.
	In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform., Scholz EP, Alter M, Zitron E, Kiesecker C, Kathöfer S, Thomas D, Kreye VA, Kreuzer J, Becker R, Katus HA, Greten J, Karle CA., Toxicol Lett. August 20, 2006; 165 (2): 156-66.
	[Electrophysiological characterization of long QT syndrome associated mutations V630A and N633S]., She HR, Teng SY, Pu JL, Shang ZL, Hui RT., Zhonghua Xin Xue Guan Bing Za Zhi. June 1, 2006; 34 (6): 523-7.
	Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels., Kiesecker C, Alter M, Kathöfer S, Zitron E, Scholz EP, Thomas D, Kreuzer J, Katus HA, Bauer A, Karle CA., Naunyn Schmiedebergs Arch Pharmacol. June 1, 2006; 373 (3): 212-20.
	Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels., Clarke CE, Hill AP, Zhao J, Kondo M, Subbiah RN, Campbell TJ, Vandenberg JI., J Physiol. June 1, 2006; 573 (Pt 2): 291-304.
	Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine., Lee SY, Kim YJ, Kim KT, Choe H, Jo SH., Br J Pharmacol. June 1, 2006; 148 (4): 499-509.
	Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels., Diness TG, Hansen RS, Olesen SP, Grunnet M., Biochem Biophys Res Commun. May 19, 2006; 343 (4): 1224-33.
	The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel., Ferrer T, Rupp J, Piper DR, Tristani-Firouzi M., J Biol Chem. May 5, 2006; 281 (18): 12858-64.
	Molecular determinants of HERG channel block., Kamiya K, Niwa R, Mitcheson JS, Sanguinetti MC., Mol Pharmacol. May 1, 2006; 69 (5): 1709-16.
	Chemical modification of the human ether-a-go-go-related gene (HERG) K+ current by the amino-group reagent trinitrobenzene sulfonic acid., Jo SH, Choi SY, Yun JH, Koh YS, Ho WK, Lee CO, Lee CO., Arch Pharm Res. April 1, 2006; 29 (4): 310-7.
	Inhibition of cardiac HERG potassium channels by antidepressant maprotiline., Ferrer-Villada T, Navarro-Polanco RA, Rodríguez-Menchaca AA, Benavides-Haro DE, Sánchez-Chapula JA., Eur J Pharmacol. February 15, 2006; 531 (1-3): 1-8.
	Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs., Perry M, Stansfeld PJ, Leaney J, Wood C, de Groot MJ, Leishman D, Sutcliffe MJ, Mitcheson JS., Mol Pharmacol. February 1, 2006; 69 (2): 509-19.
	Mechanism of action of a novel human ether-a-go-go-related gene channel activator., Casis O, Olesen SP, Sanguinetti MC., Mol Pharmacol. February 1, 2006; 69 (2): 658-65.
	A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new alpha-KTX subfamily., Abdel-Mottaleb Y, Coronas FV, de Roodt AR, Possani LD, Tytgat J., FEBS Lett. January 23, 2006; 580 (2): 592-6.
	Block of hERG channel by ziprasidone: biophysical properties and molecular determinants., Su Z, Chen J, Martin RL, McDermott JS, Cox BF, Gopalakrishnan M, Gintant GA., Biochem Pharmacol. January 12, 2006; 71 (3): 278-86.
	Involvement of Golgin-160 in cell surface transport of renal ROMK channel: co-expression of Golgin-160 increases ROMK currents., Bundis F, Neagoe I, Schwappach B, Steinmeyer K., Cell Physiol Biochem. January 1, 2006; 17 (1-2): 1-12.
	Block of HERG channels by berberine: mechanisms of voltage- and state-dependence probed with site-directed mutant channels., Rodriguez-Menchaca A, Ferrer-Villada T, Lara J, Fernandez D, Navarro-Polanco RA, Sanchez-Chapula JA., J Cardiovasc Pharmacol. January 1, 2006; 47 (1): 21-9.
	The effects of sevoflurane and propofol on QT interval and heterologously expressed human ether-a-go-go related gene currents in Xenopus oocytes., Yamada M, Hatakeyama N, Malykhina AP, Yamazaki M, Momose Y, Akbarali HI., Anesth Analg. January 1, 2006; 102 (1): 98-103.
	Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)., Hansen RS, Diness TG, Christ T, Demnitz J, Ravens U, Olesen SP, Grunnet M., Mol Pharmacol. January 1, 2006; 69 (1): 266-77.
	Expression and functional characterization of the human ether-à-go-go-related gene (HERG) K+ channel cardiac splice variant in Xenopus laevis oocytes., Aydar E, Palmer C., J Membr Biol. January 1, 2006; 211 (2): 115-26.
	Upregulation of HERG channels by the serum and glucocorticoid inducible kinase isoform SGK3., Maier G, Palmada M, Rajamanickam J, Shumilina E, Böhmer C, Lang F., Cell Physiol Biochem. January 1, 2006; 18 (4-5): 177-86.
	Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed., Subbiah RN, Kondo M, Campbell TJ, Vandenberg JI., J Physiol. December 1, 2005; 569 (Pt 2): 367-79.
	Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome., Grunnet M, Behr ER, Calloe K, Hofman-Bang J, Till J, Christiansen M, McKenna WJ, Olesen SP, Schmitt N., Heart Rhythm. November 1, 2005; 2 (11): 1238-49.
	Inhibitory effect of rhynchophylline on human ether-a-go-go related gene channel., Gui L, Li ZW, Du R, Yuan GH, Li W, Ren FX, Li J, Yang JG., Sheng Li Xue Bao. October 25, 2005; 57 (5): 648-52.
	Interactions between charged residues in the transmembrane segments of the voltage-sensing domain in the hERG channel., Zhang M, Liu J, Jiang M, Wu DM, Sonawane K, Guy HR, Tseng GN., J Membr Biol. October 1, 2005; 207 (3): 169-81.
	Molecular mapping of a site for Cd2+-induced modification of human ether-à-go-go-related gene (hERG) channel activation., Fernandez D, Ghanta A, Kinard KI, Sanguinetti MC., J Physiol. September 15, 2005; 567 (Pt 3): 737-55.
	In vivo targeting of ERG potassium channels in mice and dogs by a positron-emitting analogue of fluoroclofilium., Kim SW, Yang SD, Ahn BJ, Park JH, Lee DS, Gessner G, Heinemann SH, Herdering W, Yu KH., Exp Mol Med. August 31, 2005; 37 (4): 269-75.
	Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation., Scholz EP, Zitron E, Kiesecker C, Lück S, Thomas D, Kathöfer S, Kreye VA, Katus HA, Kiehn J, Schoels W, Karle CA., Naunyn Schmiedebergs Arch Pharmacol. June 1, 2005; 371 (6): 516-25.

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