Papers associated with kcnh2

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	Relevance of the proximal domain in the amino-terminus of HERG channels for regulation by a phospholipase C-coupled hormone receptor., Gómez-Varela D, Barros F, Viloria CG, Giráldez T, Manso DG, Dupuy SG, Miranda P, de la Peña P., FEBS Lett. January 30, 2003; 535 (1-3): 125-30.
	Cloning and functional characterization of the smooth muscle ether-a-go-go-related gene K+ channel. Potential role of a conserved amino acid substitution in the S4 region., Shoeb F, Malykhina AP, Akbarali HI., J Biol Chem. January 24, 2003; 278 (4): 2503-14.
	Functionally-distinct proton-binding in HERG suggests the presence of two binding sites., Bett GC, Rasmusson RL., Cell Biochem Biophys. January 1, 2003; 39 (3): 183-93.
	Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241., Gessner G, Heinemann SH., Br J Pharmacol. January 1, 2003; 138 (1): 161-71.
	Inhibitory effect of the class III antiarrhythmic drug nifekalant on HERG channels: mode of action., Kushida S, Ogura T, Komuro I, Nakaya H., Eur J Pharmacol. December 13, 2002; 457 (1): 19-27.
	Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-à-go-go-Related Gene., Roti EC, Myers CD, Ayers RA, Boatman DE, Delfosse SA, Chan EK, Ackerman MJ, January CT, Robertson GA., J Biol Chem. December 6, 2002; 277 (49): 47779-85.
	The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia., Scherer CR, Lerche C, Decher N, Dennis AT, Maier P, Ficker E, Busch AE, Wollnik B, Steinmeyer K., Br J Pharmacol. November 1, 2002; 137 (6): 892-900.
	Structural and functional role of the extracellular s5-p linker in the HERG potassium channel., Liu J, Zhang M, Jiang M, Tseng GN., J Gen Physiol. November 1, 2002; 120 (5): 723-37.
	Fenamate-induced enhancement of heterologously expressed HERG currents in Xenopus oocytes., Malykhina AP, Shoeb F, Akbarali HI., Eur J Pharmacol. October 11, 2002; 452 (3): 269-77.
	Kinetic modulation of HERG potassium channels by the volatile anesthetic halothane., Li J, Correa AM., Anesthesiology. October 1, 2002; 97 (4): 921-30.
	KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current., Angelo K, Jespersen T, Grunnet M, Nielsen MS, Klaerke DA, Olesen SP., Biophys J. October 1, 2002; 83 (4): 1997-2006.
	Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels., Chen J, Seebohm G, Sanguinetti MC., Proc Natl Acad Sci U S A. September 17, 2002; 99 (19): 12461-6.
	Bertosamil blocks HERG potassium channels in their open and inactivated states., Zitron E, Karle CA, Wendt-Nordahl G, Kathöfer S, Zhang W, Thomas D, Weretka S, Kiehn J., Br J Pharmacol. September 1, 2002; 137 (2): 221-8.
	KCNE4 is an inhibitory subunit to the KCNQ1 channel., Grunnet M, Jespersen T, Rasmussen HB, Ljungstrøm T, Jorgensen NK, Olesen SP, Klaerke DA., J Physiol. July 1, 2002; 542 (Pt 1): 119-30.
	Open channel block by KCB-328 [1-(2-amino-4-methanesulfonamidophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane hydrochloride] of the heterologously expressed human ether-a-go-go-related gene K+ channels., Park JB, Choe H, Lee YK, Ha KC, Rhee KS, Ko JK, Joo CU, Chae SW, Kwak YG., J Pharmacol Exp Ther. July 1, 2002; 302 (1): 314-9.
	Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block., Sánchez-Chapula JA, Navarro-Polanco RA, Culberson C, Chen J, Sanguinetti MC., J Biol Chem. June 28, 2002; 277 (26): 23587-95.
	[Evaluation of pro-arrhythmic risk of drugs due to QT interval prolongation by the HERG expression system]., Chachin M, Kurachi Y., Nihon Yakurigaku Zasshi. June 1, 2002; 119 (6): 345-51.
	Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels., Tristani-Firouzi M, Chen J, Sanguinetti MC., J Biol Chem. May 24, 2002; 277 (21): 18994-9000.
	Influence of amino-terminal structures on kinetic transitions between several closed and open states in human erg K+ channels., Gómez-Varela D, de la Peña P, García J, Giráldez T, Barros F., J Membr Biol. May 15, 2002; 187 (2): 117-33.
	Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line., Wei Z, Thomas D, Karle CA, Kathöfer S, Schenkel J, Kreye VA, Ficker E, Wible BA, Kiehn J., Chin Med J (Engl). May 1, 2002; 115 (5): 668-76.
	Characterization of a novel missense mutation E637K in the pore-S6 loop of HERG in a patient with long QT syndrome., Hayashi K, Shimizu M, Ino H, Yamaguchi M, Mabuchi H, Hoshi N, Higashida H., Cardiovasc Res. April 1, 2002; 54 (1): 67-76.
	A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?, Weerapura M, Nattel S, Chartier D, Caballero R, Hébert TE., J Physiol. April 1, 2002; 540 (Pt 1): 15-27.
	Histidines 578 and 587 in the S5-S6 linker of the human Ether-a-gogo Related Gene-1 K+ channels confer sensitivity to reactive oxygen species., Pannaccione A, Castaldo P, Ficker E, Annunziato L, Taglialatela M., J Biol Chem. March 15, 2002; 277 (11): 8912-9.
	Fast and slow voltage sensor movements in HERG potassium channels., Smith PL, Yellen G., J Gen Physiol. March 1, 2002; 119 (3): 275-93.
	Dofetilide block involves interactions with open and inactivated states of HERG channels., Weerapura M, Hébert TE, Nattel S., Pflugers Arch. February 1, 2002; 443 (4): 520-31.
	The antidepressant drug fluoxetine is an inhibitor of human ether-a-go-go-related gene (HERG) potassium channels., Thomas D, Gut B, Wendt-Nordahl G, Kiehn J., J Pharmacol Exp Ther. February 1, 2002; 300 (2): 543-8.
	Mapping the receptor site for ergtoxin, a specific blocker of ERG channels., Pardo-López L, García-Valdés J, Gurrola GB, Robertson GA, Possani LD., FEBS Lett. January 2, 2002; 510 (1-2): 45-9.
	Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes., Witchel HJ, Milnes JT, Mitcheson JS, Hancox JC., J Pharmacol Toxicol Methods. January 1, 2002; 48 (2): 65-80.
	[Cardiotoxicity of lindane, a gamma isomer of hexachlorocyclohexane]., Sauviat MP, Pages N., J Soc Biol. January 1, 2002; 196 (4): 339-48.
	Inhibition of cardiac potassium currents by pentobarbital., Bachmann A, Mueller S, Kopp K, Brueggemann A, Suessbrich H, Gerlach U, Busch AE., Naunyn Schmiedebergs Arch Pharmacol. January 1, 2002; 365 (1): 29-37.
	Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels., Ficker E, Jarolimek W, Brown AM., Mol Pharmacol. December 1, 2001; 60 (6): 1343-8.
	Characterization of a novel Kv1.5 channel blocker in Xenopus oocytes, CHO cells, human and rat cardiomyocytes., Bachmann A, Gutcher I, Kopp K, Brendel J, Bosch RF, Busch AE, Gögelein H., Naunyn Schmiedebergs Arch Pharmacol. November 1, 2001; 364 (5): 472-8.
	The S4-S5 linker couples voltage sensing and activation of pacemaker channels., Chen J, Mitcheson JS, Tristani-Firouzi M, Lin M, Sanguinetti MC., Proc Natl Acad Sci U S A. September 25, 2001; 98 (20): 11277-82.
	Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel., Huang FD, Chen J, Lin M, Keating MT, Sanguinetti MC., Circulation. August 28, 2001; 104 (9): 1071-5.
	Effects of gallium and mercury ions on transport systems., Moschèn, Schweizer K, Wagner CA, Geis-Gerstorfer J, Lang F., J Dent Res. August 1, 2001; 80 (8): 1753-7.
	Open channel block of HERG K(+) channels by vesnarinone., Kamiya K, Mitcheson JS, Yasui K, Kodama I, Sanguinetti MC., Mol Pharmacol. August 1, 2001; 60 (2): 244-53.
	Differential effects of general anesthetics on G protein-coupled inwardly rectifying and other potassium channels., Yamakura T, Lewohl JM, Harris RA., Anesthesiology. July 1, 2001; 95 (1): 144-53.
	Functional characterization of the C-terminus of the human ether-à-go-go-related gene K(+) channel (HERG)., Aydar E, Palmer C., J Physiol. July 1, 2001; 534 (Pt 1): 1-14.
	Testosterone-mediated modulation of HERG blockade by proarrhythmic agents., Shuba YM, Degtiar VE, Osipenko VN, Naidenov VG, Woosley RL., Biochem Pharmacol. July 1, 2001; 62 (1): 41-9.
	Molecular cloning and expression of cERG, the ether à go-go-related gene from canine myocardium., Zehelein J, Zhang W, Koenen M, Graf M, Heinemann SH, Katus HA., Pflugers Arch. May 1, 2001; 442 (2): 188-91.
	High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872., Thomas D, Wendt-Nordahl G, Röckl K, Ficker E, Brown AM, Kiehn J., J Pharmacol Exp Ther. May 1, 2001; 297 (2): 753-61.
	Blocking effects of the antiarrhythmic drug propafenone on the HERG potassium channel., Mergenthaler J, Haverkamp W, Hüttenhofer A, Skryabin BV, Musshoff U, Borggrefe M, Speckmann EJ, Breithardt G, Madeja M., Naunyn Schmiedebergs Arch Pharmacol. April 1, 2001; 363 (4): 472-80.
	Short- and long-term effects of amiodarone on the two components of cardiac delayed rectifier K(+) current., Kamiya K, Nishiyama A, Yasui K, Hojo M, Sanguinetti MC, Kodama I., Circulation. March 6, 2001; 103 (9): 1317-24.
	Inhibitory effects of berberine on IK1, IK, and HERG channels of cardiac myocytes., Li BX, Yang BF, Zhou J, Xu CQ, Li YR., Acta Pharmacol Sin. February 1, 2001; 22 (2): 125-31.
	Antiarrhythmic drug carvedilol inhibits HERG potassium channels., Karle CA, Kreye VA, Thomas D, Röckl K, Kathöfer S, Zhang W, Kiehn J., Cardiovasc Res. February 1, 2001; 49 (2): 361-70.
	[Testosterone modulation of HERG potassium channel blockade induced by neuroleptics]., Osypenko VM, Dehtiar VIe, Shuba IaM, Naĭd'onov VH., Fiziol Zh. January 1, 2001; 47 (3): 11-8.
	[Effects of sex hormones on HERG potassium channels expressed in Xenopus oocytes]., Osypenko VM, Dehtiar VIe, Naĭd'onov VH, Shuba IaM., Fiziol Zh. January 1, 2001; 47 (2): 24-31.
	[Blockade of HERG K+ channels expressed in Xenopus oocytes by antipsychotic agents]., Osypenko VM, Degtiar VIe, Naid'onov VG, Shuba IaM., Fiziol Zh. January 1, 2001; 47 (1): 17-25.
	Inhibition of IKs channels by HMR 1556., Gögelein H, Brüggemann A, Gerlach U, Brendel J, Busch AE., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2000; 362 (6): 480-8.
	KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel., Tinel N, Diochot S, Borsotto M, Lazdunski M, Barhanin J., EMBO J. December 1, 2000; 19 (23): 6326-30.

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