Papers associated with kcnh2

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	Human Ether-à-go-go Related Gene (hERG) Channel Blocking Aporphine Alkaloids from Lotus Leaves and Their Quantitative Analysis in Dietary Weight Loss Supplements., Grienke U, Mair CE, Saxena P, Baburin I, Scheel O, Ganzera M, Schuster D, Hering S, Rollinger JM., J Agric Food Chem. June 17, 2015; 63 (23): 5634-9.
	The Link between Inactivation and High-Affinity Block of hERG1 Channels., Wu W, Gardner A, Sanguinetti MC., Mol Pharmacol. June 1, 2015; 87 (6): 1042-50.
	Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Liu QN, Trudeau MC., PLoS One. April 22, 2015; 10 (4): e0123951.
	Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains., Lörinczi É, Gómez-Posada JC, de la Peña P, Tomczak AP, Fernández-Trillo J, Leipscher U, Stühmer W, Barros F, Pardo LA., Nat Commun. March 30, 2015; 6 6672.
	Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways., Goodchild SJ, Macdonald LC, Fedida D., Biophys J. March 24, 2015; 108 (6): 1435-1447.
	NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation., Guo J, Cheng YM, Lees-Miller JP, Perissinotti LL, Claydon TW, Hull CM, Thouta S, Roach DE, Durdagi S, Noskov SY, Duff HJ., Biophys J. March 24, 2015; 108 (6): 1400-1413.
	Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action., Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP., Drug Des Devel Ther. February 16, 2015; 9 867-77.
	High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance., Steffensen AB, Refaat MM, David JP, Mujezinovic A, Calloe K, Wojciak J, Nussbaum RL, Scheinman MM, Schmitt N., Sci Rep. January 12, 2015; 5 10009.
	Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels., Cristofori-Armstrong B, Soh MS, Talwar S, Brown DL, Griffin JD, Dekan Z, Stow JL, King GF, Lynch JW, Rash LD., Sci Rep. January 12, 2015; 5 14763.
	Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243., Wu W, Gardner A, Sanguinetti MC., Mol Pharmacol. January 1, 2015; 87 (3): 401-9.
	Cooperative subunit interactions mediate fast C-type inactivation of hERG1 K+ channels., Wu W, Gardner A, Sanguinetti MC., J Physiol. October 15, 2014; 592 (20): 4465-80.
	Regional flexibility in the S4-S5 linker regulates hERG channel closed-state stabilization., Hull CM, Sokolov S, Van Slyke AC, Claydon TW., Pflugers Arch. October 1, 2014; 466 (10): 1911-9.
	Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels., Ng CA, Phan K, Hill AP, Vandenberg JI, Perry MD., J Biol Chem. September 12, 2014; 289 (37): 25822-32.
	Ginseng gintonin activates the human cardiac delayed rectifier K+ channel: involvement of Ca2+/calmodulin binding sites., Choi SH, Lee BH, Kim HJ, Jung SW, Kim HS, Shin HC, Lee JH, Kim HC, Rhim H, Hwang SH, Ha TS, Kim HJ, Cho H, Nah SY., Mol Cells. September 1, 2014; 37 (9): 656-63.
	Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channels., Thomson SJ, Hansen A, Sanguinetti MC., J Biol Chem. August 22, 2014; 289 (34): 23428-36.
	Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics., Lundby A, Rossin EJ, Steffensen AB, Acha MR, Newton-Cheh C, Pfeufer A, Lynch SN, QT Interval International GWAS Consortium (QT-IGC), Olesen SP, Brunak S, Ellinor PT, Jukema JW, Trompet S, Ford I, Macfarlane PW, Krijthe BP, Hofman A, Uitterlinden AG, Stricker BH, Nathoe HM, Spiering W, Daly MJ, Asselbergs FW, van der Harst P, Milan DJ, de Bakker PI, Lage K, Olsen JV., Nat Methods. August 1, 2014; 11 (8): 868-74.
	Functional evolution of Erg potassium channel gating reveals an ancient origin for IKr., Martinson AS, van Rossum DB, Diatta FH, Layden MJ, Rhodes SA, Martindale MQ, Jegla T., Proc Natl Acad Sci U S A. April 15, 2014; 111 (15): 5712-7.
	Novel TASK channels inhibitors derived from dihydropyrrolo[2,1-a]isoquinoline., Noriega-Navarro R, Lopez-Charcas O, Hernández-Enríquez B, Reyes-Gutiérrez PE, Martínez R, Landa A, Morán J, Gomora JC, Garcia-Valdes J., Neuropharmacology. April 1, 2014; 79 28-36.
	Stoichiometry of altered hERG1 channel gating by small molecule activators., Wu W, Sachse FB, Gardner A, Sanguinetti MC., J Gen Physiol. April 1, 2014; 143 (4): 499-512.
	Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate., Thouta S, Sokolov S, Abe Y, Clark SJ, Cheng YM, Claydon TW., Biophys J. March 4, 2014; 106 (5): 1057-69.
	External protons destabilize the activated voltage sensor in hERG channels., Shi YP, Cheng YM, Van Slyke AC, Claydon TW., Eur Biophys J. March 1, 2014; 43 (2-3): 59-69.
	A functional Kv1.2-hERG chimaeric channel expressed in Pichia pastoris., Dhillon MS, Cockcroft CJ, Munsey T, Smith KJ, Powell AJ, Carter P, Wrighton DC, Rong HL, Yusaf SP, Sivaprasadarao A., Sci Rep. February 26, 2014; 4 4201.
	The variant hERG/R148W associated with LQTS is a mutation that reduces current density on co-expression with the WT., Mechakra A, Vincent Y, Chevalier P, Millat G, Ficker E, Jastrzebski M, Poulin H, Pouliot V, Chahine M, Christé G., Gene. February 25, 2014; 536 (2): 348-56.
	Impact of the whole-cell patch-clamp configuration on the pharmacological assessment of the hERG channel: trazodone as a case example., Rodriguez-Menchaca AA, Ferrer T, Navarro-Polanco RA, Sanchez-Chapula JA, Moreno-Galindo EG., J Pharmacol Toxicol Methods. January 1, 2014; 69 (3): 237-44.
	Up-regulation of hERG K⁺ channels by B-RAF., Pakladok T, Hosseinzadeh Z, Almilaji A, Lebedeva A, Shumilina E, Alesutan I, Lang F., PLoS One. January 1, 2014; 9 (1): e87457.
	Up-regulation of Kir2.1 (KCNJ2) by the serum & glucocorticoid inducible SGK3., Munoz C, Pakladok T, Almilaji A, Elvira B, Decher N, Shumilina E, Lang F., Cell Physiol Biochem. January 1, 2014; 33 (2): 491-500.
	The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels., Lin TF, Jow GM, Fang HY, Fu SJ, Wu HH, Chiu MM, Jeng CJ., PLoS One. January 1, 2014; 9 (10): e110423.
	Chimeric hERG channels containing a tetramerization domain are functional and stable., Hausammann GJ, Grütter MG., Biochemistry. December 23, 2013; 52 (51): 9237-45.
	AMP-activated protein kinase regulates hERG potassium channel., Almilaji A, Munoz C, Elvira B, Fajol A, Pakladok T, Honisch S, Shumilina E, Lang F, Föller M., Pflugers Arch. November 1, 2013; 465 (11): 1573-82.
	C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels., Ng CA, Ke Y, Perry MD, Tan PS, Hill AP, Vandenberg JI., PLoS One. October 4, 2013; 8 (10): e77032.
	BcsTx3 is a founder of a novel sea anemone toxin family of potassium channel blocker., Orts DJ, Moran Y, Cologna CT, Peigneur S, Madio B, Praher D, Quinton L, De Pauw E, Bicudo JE, Tytgat J, de Freitas JC., FEBS J. October 1, 2013; 280 (19): 4839-52.
	Coxsackievirus B3 modulates cardiac ion channels., Steinke K, Sachse F, Ettischer N, Strutz-Seebohm N, Henrion U, Rohrbeck M, Klosowski R, Wolters D, Brunner S, Franz WM, Pott L, Munoz C, Kandolf R, Schulze-Bahr E, Lang F, Klingel K, Seebohm G., FASEB J. October 1, 2013; 27 (10): 4108-21.
	Procaine, a state-dependent blocker, inhibits HERG channels by helix residue Y652 and F656 in the S6 transmembrane domain., Wang N, Ma JH, Zhang PH., J Pharmacol Sci. September 20, 2013; 123 (1): 25-35.
	Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel., Park MH, Lee SH, Chu DH, Won KH, Choi BH, Choe H, Jo SH., J Pharmacol Sci. September 20, 2013; 123 (1): 67-77.
	Acute and subacute effects of the selective serotonin-noradrenaline reuptake inhibitor duloxetine on cardiac hERG channels., Fischer F, Vonderlin N, Seyler C, Zitron E, Schernus B, Katus H, Scholz E., Naunyn Schmiedebergs Arch Pharmacol. September 1, 2013; 386 (9): 795-804.
	Blockade of the human ether-a-go-go-related gene potassium channel by ketamine., Zhang P, Xing J, Luo A, Feng J, Liu Z, Gao C, Ma J., J Pharm Pharmacol. September 1, 2013; 65 (9): 1321-8.
	Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels., Cheng YM, Hull CM, Niven CM, Qi J, Allard CR, Claydon TW., J Gen Physiol. September 1, 2013; 142 (3): 289-303.
	Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels., Perry MD, Wong S, Ng CA, Vandenberg JI., J Gen Physiol. September 1, 2013; 142 (3): 275-88.
	The neutral, hydrophobic isoleucine at position I521 in the extracellular S4 domain of hERG contributes to channel gating equilibrium., Dou Y, Goodchild SJ, Velde RV, Wu Y, Fedida D., Am J Physiol Cell Physiol. August 15, 2013; 305 (4): C468-78.
	Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions., Ke Y, Ng CA, Hunter MJ, Mann SA, Heide J, Hill AP, Vandenberg JI., Biochem J. August 15, 2013; 454 (1): 69-77.
	Klotho sensitivity of the hERG channel., Munoz C, Pakladok T, Almilaji A, Elvira B, Seebohm G, Voelkl J, Föller M, Shumilina E, Lang F., FEBS Lett. June 5, 2013; 587 (11): 1663-8.
	VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus., Ciau-Uitz A, Pinheiro P, Kirmizitas A, Zuo J, Patient R., Development. June 1, 2013; 140 (12): 2632-42.
	External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor., Kazmierczak M, Zhang X, Chen B, Mulkey DK, Shi Y, Wagner PG, Pivaroff-Ward K, Sassic JK, Bayliss DA, Jegla T., J Gen Physiol. June 1, 2013; 141 (6): 721-35.
	Mapping of interactions between the N- and C-termini and the channel core in HERG K+ channels., de la Peña P, Machín A, Fernández-Trillo J, Domínguez P, Barros F., Biochem J. May 1, 2013; 451 (3): 463-74.
	ZC88, a novel 4-amino piperidine analog, inhibits the growth of neuroblastoma cells through blocking hERG potassium channel., Wei X, Sun H, Yan H, Zhang C, Zhang S, Liu X, Hua N, Ma X, Zheng J., Cancer Biol Ther. May 1, 2013; 14 (5): 450-7.
	Pore helices play a dynamic role as integrators of domain motion during Kv11.1 channel inactivation gating., Perry MD, Ng CA, Vandenberg JI., J Biol Chem. April 19, 2013; 288 (16): 11482-91.
	Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells., Jehle J, Ficker E, Wan X, Deschenes I, Kisselbach J, Wiedmann F, Staudacher I, Schmidt C, Schweizer PA, Becker R, Katus HA, Thomas D., Br J Pharmacol. March 1, 2013; 168 (5): 1215-29.
	Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration., Hong HK, Lee BH, Park MH, Lee SH, Chu D, Kim WJ, Choe H, Hee Choi B, Jo SH., Eur J Pharmacol. February 28, 2013; 702 (1-3): 165-73.
	The eag domain regulates hERG channel inactivation gating via a direct interaction., Gustina AS, Trudeau MC., J Gen Physiol. February 1, 2013; 141 (2): 229-41.
	Blocking of the human ether-à-go-go-related gene channel by imatinib mesylate., Dong Q, Fu XX, Du LL, Zhao N, Xia CK, Yu KW, Cheng LX, Du YM., Biol Pharm Bull. January 1, 2013; 36 (2): 268-75.

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