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Summary Expression Phenotypes Gene Literature (440) GO Terms (0) Nucleotides (50) Proteins (39) Interactants (235) Wiki
XB-GENEPAGE-983103

Papers associated with kcnh2



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A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel., Sanguinetti MC, Jiang C, Curran ME, Keating MT., Cell. April 21, 1995; 81 (2): 299-307.

Cloned human inward rectifier K+ channel as a target for class III methanesulfonanilides., Kiehn J, Wible B, Ficker E, Taglialatela M, Brown AM., Circ Res. December 1, 1995; 77 (6): 1151-5.

Potassium currents expressed from Drosophila and mouse eag cDNAs in Xenopus oocytes., Robertson GA, Warmke JM, Ganetzky B., Neuropharmacology. January 1, 1996; 35 (7): 841-50.

Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides., Spector PS, Curran ME, Keating MT, Sanguinetti MC., Circ Res. March 1, 1996; 78 (3): 499-503.

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia., Sanguinetti MC, Curran ME, Spector PS, Keating MT., Proc Natl Acad Sci U S A. March 5, 1996; 93 (5): 2208-12.

Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole., Suessbrich H, Waldegger S, Lang F, Busch AE., FEBS Lett. April 29, 1996; 385 (1-2): 77-80.

Fast inactivation causes rectification of the IKr channel., Spector PS, Curran ME, Zou A, Keating MT, Sanguinetti MC., J Gen Physiol. May 1, 1996; 107 (5): 611-9.

High affinity open channel block by dofetilide of HERG expressed in a human cell line., Snyders DJ, Chaudhary A., Mol Pharmacol. June 1, 1996; 49 (6): 949-55.

Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel., Schönherr R, Heinemann SH., J Physiol. June 15, 1996; 493 ( Pt 3) 635-42.

HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine., Roy M, Dumaine R, Brown AM., Circulation. August 15, 1996; 94 (4): 817-23.

Inhibition of IKs in guinea pig cardiac myocytes and guinea pig IsK channels by the chromanol 293B., Busch AE, Suessbrich H, Waldegger S, Sailer E, Greger R, Lang H, Lang F, Gibson KJ, Maylie JG., Pflugers Arch. October 1, 1996; 432 (6): 1094-6.

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current., Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M, Romey G., Nature. November 7, 1996; 384 (6604): 78-80.

Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide., Kiehn J, Lacerda AE, Wible B, Brown AM., Circulation. November 15, 1996; 94 (10): 2572-9.

Mechanism of action potential prolongation by RP 58866 and its active enantiomer, terikalant. Block of the rapidly activating delayed rectifier K+ current, IKr., Jurkiewicz NK, Wang J, Fermini B, Sanguinetti MC, Salata JJ., Circulation. December 1, 1996; 94 (11): 2938-46.

Tissue and species distribution of mRNA for the IKr-like K+ channel, erg., Wymore RS, Gintant GA, Wymore RT, Dixon JE, McKinnon D, Cohen IS., Circ Res. February 1, 1997; 80 (2): 261-8.

The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes., Suessbrich H, Schönherr R, Heinemann SH, Attali B, Lang F, Busch AE., Br J Pharmacol. March 1, 1997; 120 (5): 968-74.

Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes., Zou A, Curran ME, Keating MT, Sanguinetti MC., Am J Physiol. March 1, 1997; 272 (3 Pt 2): H1309-14.

Suppression of mammalian K+ channel family by ebastine., Ko CM, Ducic I, Fan J, Shuba YM, Morad M., J Pharmacol Exp Ther. April 1, 1997; 281 (1): 233-44.

Comparative effects of loratadine and terfenadine on cardiac K+ channels., Ducic I, Ko CM, Shuba Y, Morad M., J Cardiovasc Pharmacol. July 1, 1997; 30 (1): 42-54.

A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes., Wang S, Liu S, Morales MJ, Strauss HC, Rasmusson RL., J Physiol. July 1, 1997; 502 ( Pt 1) 45-60.

A minK-HERG complex regulates the cardiac potassium current I(Kr)., McDonald TV, Yu Z, Ming Z, Palma E, Meyers MB, Wang KW, Goldstein SA, Fishman GI., Nature. July 17, 1997; 388 (6639): 289-92.

Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment., Terlau H, Heinemann SH, Stühmer W, Pongs O, Ludwig J., J Physiol. August 1, 1997; 502 ( Pt 3) 537-43.

Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart., Lacerda AE, Roy ML, Lewis EW, Rampe D., Mol Pharmacol. August 1, 1997; 52 (2): 314-22.

Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241., Suessbrich H, Schönherr R, Heinemann SH, Lang F, Busch AE., FEBS Lett. September 8, 1997; 414 (2): 435-8.

Suppression of slow delayed rectifier current by a truncated isoform of KvLQT1 cloned from normal human heart., Jiang M, Tseng-Crank J, Tseng GN., J Biol Chem. September 26, 1997; 272 (39): 24109-12.

Regulation of the human ether-a-gogo related gene (HERG) K+ channels by reactive oxygen species., Taglialatela M, Castaldo P, Iossa S, Pannaccione A, Fresi A, Ficker E, Annunziato L., Proc Natl Acad Sci U S A. October 14, 1997; 94 (21): 11698-703.

Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current., London B, Trudeau MC, Newton KP, Beyer AK, Copeland NG, Gilbert DJ, Jenkins NA, Satler CA, Robertson GA., Circ Res. November 1, 1997; 81 (5): 870-8.

Electrophysiological characterization of an alternatively processed ERG K+ channel in mouse and human hearts., Lees-Miller JP, Kondo C, Wang L, Duff HJ., Circ Res. November 1, 1997; 81 (5): 719-26.

Modulation of HERG affinity for E-4031 by [K+]o and C-type inactivation., Wang S, Morales MJ, Liu S, Strauss HC, Rasmusson RL., FEBS Lett. November 3, 1997; 417 (1): 43-7.

Identification of two nervous system-specific members of the erg potassium channel gene family., Shi W, Wymore RS, Wang HS, Pan Z, Cohen IS, McKinnon D, Dixon JE., J Neurosci. December 15, 1997; 17 (24): 9423-32.

Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action., Busch AE, Eigenberger B, Jurkiewicz NK, Salata JJ, Pica A, Suessbrich H, Lang F., Br J Pharmacol. January 1, 1998; 123 (1): 23-30.

herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells?, Bianchi L, Wible B, Arcangeli A, Taglialatela M, Morra F, Castaldo P, Crociani O, Rosati B, Faravelli L, Olivotto M, Wanke E., Cancer Res. February 15, 1998; 58 (4): 815-22.

Molecular determinants of dofetilide block of HERG K+ channels., Ficker E, Jarolimek W, Kiehn J, Baumann A, Brown AM., Circ Res. February 23, 1998; 82 (3): 386-95.

Voltage-dependent blockade of HERG channels expressed in Xenopus oocytes by external Ca2+ and Mg2+., Ho WK, Kim I, Lee CO, Lee CO, Earm YE., J Physiol. March 15, 1998; 507 ( Pt 3) (Pt 3): 631-8.

Effects of the chromanol 293B, a selective blocker of the slow, component of the delayed rectifier K+ current, on repolarization in human and guinea pig ventricular myocytes., Bosch RF, Gaspo R, Busch AE, Lang HJ, Li GR, Nattel S., Cardiovasc Res. May 1, 1998; 38 (2): 441-50.

A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation., Zou A, Xu QP, Sanguinetti MC., J Physiol. May 15, 1998; 509 ( Pt 1) 129-37.

Differential effects of bupivacaine on cardiac K channels: role of channel inactivation and subunit composition in drug-channel interaction., Lipka LJ, Jiang M, Tseng GN., J Cardiovasc Electrophysiol. July 1, 1998; 9 (7): 727-42.

Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines., Taglialatela M, Pannaccione A, Castaldo P, Giorgio G, Zhou Z, January CT, Genovese A, Marone G, Annunziato L., Mol Pharmacol. July 1, 1998; 54 (1): 113-21.

Blockade of HERG and Kv1.5 by ketoconazole., Dumaine R, Roy ML, Brown AM., J Pharmacol Exp Ther. August 1, 1998; 286 (2): 727-35.

Novel mechanism of HERG current suppression in LQT2: shift in voltage dependence of HERG inactivation., Nakajima T, Furukawa T, Tanaka T, Katayama Y, Nagai R, Nakamura Y, Hiraoka M., Circ Res. August 24, 1998; 83 (4): 415-22.

Modulation of human erg K+ channel gating by activation of a G protein-coupled receptor and protein kinase C., Barros F, Gomez-Varela D, Viloria CG, Palomero T, Giráldez T, de la Peña P., J Physiol. September 1, 1998; 511 ( Pt 2) 333-46.

HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways., Kiehn J, Karle C, Thomas D, Yao X, Brachmann J, Kübler W., J Biol Chem. September 25, 1998; 273 (39): 25285-91.

Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channels., Wang J, Trudeau MC, Zappia AM, Robertson GA., J Gen Physiol. November 1, 1998; 112 (5): 637-47.              

Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain., Morais Cabral JH, Lee A, Cohen SL, Chait BT, Li M, Mackinnon R., Cell. November 25, 1998; 95 (5): 649-55.

Effect of verapamil enantiomers and metabolites on cardiac K+ channels expressed in Xenopus oocytes., Waldegger S, Niemeyer G, Mörike K, Wagner CA, Suessbrich H, Busch AE, Lang F, Eichelbaum M., Cell Physiol Biochem. January 1, 1999; 9 (2): 81-9.

Modulation of HERG potassium channels by extracellular magnesium and quinidine., Po SS, Wang DW, Yang IC, Johnson JP, Nie L, Bennett PB., J Cardiovasc Pharmacol. February 1, 1999; 33 (2): 181-5.

Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes., Sanguinetti MC, Xu QP., J Physiol. February 1, 1999; 514 ( Pt 3) 667-75.

Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels., Kiehn J, Thomas D, Karle CA, Schöls W, Kübler W., Naunyn Schmiedebergs Arch Pharmacol. March 1, 1999; 359 (3): 212-9.

Blockade of HERG channels expressed in Xenopus laevis oocytes by external divalent cations., Ho WK, Kim I, Lee CO, Lee CO, Youm JB, Lee SH, Earm YE., Biophys J. April 1, 1999; 76 (4): 1959-71.

Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation., Chen J, Zou A, Splawski I, Keating MT, Sanguinetti MC., J Biol Chem. April 9, 1999; 274 (15): 10113-8.

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