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Summary Expression Phenotypes Gene Literature (40) GO Terms (2) Nucleotides (131) Proteins (50) Interactants (201) Wiki

Papers associated with trpv4

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Heat-evoked activation of the ion channel, TRPV4., Güler AD, Lee H, Iida T, Shimizu I, Tominaga M, Caterina M., J Neurosci. August 1, 2002; 22 (15): 6408-14.

2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3., Hu HZ, Gu Q, Wang C, Colton CK, Tang J, Kinoshita-Kawada M, Lee LY, Wood JD, Zhu MX., J Biol Chem. August 20, 2004; 279 (34): 35741-8.

Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells., Shin JB, Adams D, Paukert M, Siba M, Sidi S, Levin M, Gillespie PG, Gründer S., Proc Natl Acad Sci U S A. August 30, 2005; 102 (35): 12572-7.              

Potentiation of TRPV3 channel function by unsaturated fatty acids., Hu HZ, Xiao R, Wang C, Gao N, Colton CK, Wood JD, Zhu MX., J Cell Physiol. July 1, 2006; 208 (1): 201-12.

Evolution of thermoTRP ion channel homologs in vertebrates., Saito S, Shingai R., Physiol Genomics. November 27, 2006; 27 (3): 219-30.

A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition., Petrus M, Peier AM, Bandell M, Hwang SW, Huynh T, Olney N, Jegla T, Patapoutian A., Mol Pain. December 17, 2007; 3 40.                

Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels., Ma S, G G, Ak VE, Jf D, H H., Pak J Pharm Sci. October 1, 2008; 21 (4): 370-8.

Identification and characterization of novel TRPV4 modulators., Vincent F, Acevedo A, Nguyen MT, Dourado M, DeFalco J, Gustafson A, Spiro P, Emerling DE, Kelly MG, Duncton MA., Biochem Biophys Res Commun. November 20, 2009; 389 (3): 490-4.

Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship., Sherkheli MA, Vogt-Eisele AK, Bura D, Beltrán Márques LR, Gisselmann G, Hatt H., J Pharm Pharm Sci. January 1, 2010; 13 (2): 242-53.

Forward genetic analysis reveals multiple gating mechanisms of TRPV4., Loukin S, Su Z, Zhou X, Kung C., J Biol Chem. June 25, 2010; 285 (26): 19884-90.

Wild-type and brachyolmia-causing mutant TRPV4 channels respond directly to stretch force., Loukin S, Zhou X, Su Z, Saimi Y, Kung C., J Biol Chem. August 27, 2010; 285 (35): 27176-81.

Increased basal activity is a key determinant in the severity of human skeletal dysplasia caused by TRPV4 mutations., Loukin S, Su Z, Kung C., PLoS One. May 3, 2011; 6 (5): e19533.          

The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro., Rivera-Acevedo RE, Pless SA, Ahern CA, Schwarz SK., Anesthesiology. June 1, 2011; 114 (6): 1425-34.

Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth., Kerstein PC, Jacques-Fricke BT, Rengifo J, Mogen BJ, Williams JC, Gottlieb PA, Sachs F, Gomez TM., J Neurosci. January 2, 2013; 33 (1): 273-85.

Yeast luminometric and Xenopus oocyte electrophysiological examinations of the molecular mechanosensitivity of TRPV4., Teng J, Loukin S, Zhou X, Kung C., J Vis Exp. December 31, 2013; (82):

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4., Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, McIntyre P, Vanner SJ, Korbmacher C, Bunnett NW., J Biol Chem. September 26, 2014; 289 (39): 27215-27234.

TRPV4 associates environmental temperature and sex determination in the American alligator., Yatsu R, Miyagawa S, Kohno S, Saito S, Lowers RH, Ogino Y, Fukuta N, Katsu Y, Ohta Y, Tominaga M, Guillette LJ, Iguchi T., Sci Rep. January 12, 2015; 5 18581.        

L596-W733 bond between the start of the S4-S5 linker and the TRP box stabilizes the closed state of TRPV4 channel., Teng J, Loukin SH, Anishkin A, Kung C., Proc Natl Acad Sci U S A. March 17, 2015; 112 (11): 3386-91.

Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase., Sostegni S, Diakov A, McIntyre P, Bunnett N, Korbmacher C, Haerteis S., Pflugers Arch. April 1, 2015; 467 (4): 687-701.

Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain., Zhao P, Lieu T, Barlow N, Sostegni S, Haerteis S, Korbmacher C, Liedtke W, Jimenez-Vargas NN, Vanner SJ, Bunnett NW., J Biol Chem. May 29, 2015; 290 (22): 13875-87.

A channelopathy mechanism revealed by direct calmodulin activation of TrpV4., Loukin SH, Teng J, Kung C., Proc Natl Acad Sci U S A. July 28, 2015; 112 (30): 9400-5.                    

TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia., Jo AO, Ryskamp DA, Phuong TT, Verkman AS, Yarishkin O, MacAulay N, Križaj D., J Neurosci. September 30, 2015; 35 (39): 13525-37.                  

Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy., Sicca F, Ambrosini E, Marchese M, Sforna L, Servettini I, Valvo G, Brignone MS, Lanciotti A, Moro F, Grottesi A, Catacuzzeno L, Baldini S, Hasan S, D'Adamo MC, Franciolini F, Molinari P, Santorelli FM, Pessia M., Sci Rep. September 28, 2016; 6 34325.            

A competing hydrophobic tug on L596 to the membrane core unlatches S4-S5 linker elbow from TRP helix and allows TRPV4 channel to open., Teng J, Loukin SH, Anishkin A, Kung C., Proc Natl Acad Sci U S A. October 18, 2016; 113 (42): 11847-11852.

Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors., Kaminski MM, Tosic J, Kresbach C, Engel H, Klockenbusch J, Müller AL, Pichler R, Grahammer F, Kretz O, Huber TB, Walz G, Arnold SJ, Lienkamp SS., Nat Cell Biol. December 1, 2016; 18 (12): 1269-1280.                  

When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor., Toft-Bertelsen TL, Križaj D, MacAulay N., J Physiol. June 1, 2017; 595 (11): 3287-3302.

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms., Deng Z, Paknejad N, Maksaev G, Sala-Rabanal M, Nichols CG, Hite RK, Yuan P., Nat Struct Mol Biol. March 1, 2018; 25 (3): 252-260.

PLC and IP3-evoked Ca2+ release initiate the fast block to polyspermy in Xenopus laevis eggs., Wozniak KL, Tembo M, Phelps WA, Lee MT, Carlson AE., J Gen Physiol. September 3, 2018; 150 (9): 1239-1248.            

Calcium Signaling in Vertebrate Development and Its Role in Disease., Paudel S, Sindelar R, Saha M., Int J Mol Sci. October 30, 2018; 19 (11):     

Expression of trpv channels during Xenopus laevis embryogenesis., Dong C, Paudel S, Amoh NY, Saha MS., Gene Expr Patterns. December 1, 2018; 30 64-70.          

Human mutations highlight an intersubunit cation-π bond that stabilizes the closed but not open or inactivated states of TRPV channels., Teng J, Anishkin A, Kung C, Blount P., Proc Natl Acad Sci U S A. May 7, 2019; 116 (19): 9410-9416.

Trpc1 as the Missing Link Between the Bmp and Ca2+ Signalling Pathways During Neural Specification in Amphibians., Néant I, Leung HC, Webb SE, Miller AL, Miller AL, Moreau M, Leclerc C., Sci Rep. November 5, 2019; 9 (1): 16049.                                    

Volume sensing in the transient receptor potential vanilloid 4 ion channel is cell type-specific and mediated by an N-terminal volume-sensing domain., Toft-Bertelsen TL, Yarishkin O, Redmon S, Phuong TTT, Križaj D, MacAulay N., J Biol Chem. November 29, 2019; 294 (48): 18421-18434.                

Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension., Lakk M, Hoffmann GF, Gorusupudi A, Enyong E, Lin A, Bernstein PS, Toft-Bertelsen T, MacAulay N, Elliott MH, Križaj D., J Lipid Res. January 1, 2021; 62 100145.                          

Positive modulation of the TMEM16B mediated currents by TRPV4 antagonist., Hernandez A, Alaniz-Palacios A, Contreras-Vite JA, Martínez-Torres A., Biochem Biophys Rep. December 2, 2021; 28 101180.

Dynamic evolution of transient receptor potential vanilloid (TRPV) ion channel family with numerous gene duplications and losses., Morini M, Bergqvist CA, Asturiano JF, Larhammar D, Dufour S., Front Endocrinol (Lausanne). January 1, 2022; 13 1013868.                    

Cloning and functional characterization of medaka TRPV4., Hori S, Sakamoto N, Saitoh O., Comp Biochem Physiol A Mol Integr Physiol. May 1, 2022; 267 111182.

Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity., Doñate-Macian P, Duarte Y, Rubio-Moscardo F, Pérez-Vilaró G, Canan J, Díez J, González-Nilo F, Valverde MA., Br J Pharmacol. July 1, 2022; 179 (14): 3576-3591.

Association of novel mutation in TRPV4 with familial nonsyndromic craniosynostosis with complete penetrance and variable expressivity., Gayden T, Crevier-Sorbo G, Jawhar W, Saint-Martin C, Eveleigh R, Gilardino MS, Anastasio N, Trakadis Y, Bassenden AV, Berghuis AM, Jabado N, Dudley RWR., J Neurosurg Pediatr. June 1, 2023; 31 (6): 584-592.

Recent advances on the structure and the function relationships of the TRPV4 ion channel., Sánchez-Hernández R, Benítez-Angeles M, Hernández-Vega AM, Rosenbaum T., Channels (Austin). December 1, 2024; 18 (1): 2313323.

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