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Summary Expression Phenotypes Gene Literature (67) GO Terms (5) Nucleotides (637) Proteins (43) Interactants (593) Wiki
XB-GENEPAGE-961587

Papers associated with has1



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Differential induction of vitellogenin gene transcription and total transcriptional activity by estrogen in Xenopus laevis liver., Martin MB, Riegel AT, Schoenberg DR., J Biol Chem. February 15, 1986; 261 (5): 2355-61.

Cell interactions and the control of gene activity during early development of Xenopus laevis., Sargent TD, Jamrich M, Dawid IB., Dev Biol. March 1, 1986; 114 (1): 238-46.

Accumulation and decay of DG42 gene products follow a gradient pattern during Xenopus embryogenesis., Rosa F, Sargent TD, Rebbert ML, Michaels GS, Jamrich M, Grunz H, Jonas E, Winkles JA, Dawid IB., Dev Biol. September 1, 1988; 129 (1): 114-23.            

Gene expression in amphibian embryogenesis., Dawid IB, Rebbert ML, Rosa F, Jamrich M, Sargent TD., Cell Differ Dev. November 1, 1988; 25 Suppl 67-74.

Homology of Rhizobium meliloti NodC to polysaccharide polymerizing enzymes., Atkinson EM, Long SR., Mol Plant Microbe Interact. January 1, 1992; 5 (5): 439-42.

CSD2, CSD3, and CSD4, genes required for chitin synthesis in Saccharomyces cerevisiae: the CSD2 gene product is related to chitin synthases and to developmentally regulated proteins in Rhizobium species and Xenopus laevis., Bulawa CE., Mol Cell Biol. April 1, 1992; 12 (4): 1764-76.

The Streptococcus pyogenes hyaluronan synthase: sequence comparison and conservation among various group A strains., DeAngelis PL, Yang N, Weigel PH., Biochem Biophys Res Commun. February 28, 1994; 199 (1): 1-10.

Synthesis of "Nod"-like chitin oligosaccharides by the Xenopus developmental protein DG42., Semino CE, Robbins PW., Proc Natl Acad Sci U S A. April 11, 1995; 92 (8): 3498-501.

Expression cloning and molecular characterization of HAS protein, a eukaryotic hyaluronan synthase., Itano N, Kimata K., J Biol Chem. April 26, 1996; 271 (17): 9875-8.

Homologs of the Xenopus developmental gene DG42 are present in zebrafish and mouse and are involved in the synthesis of Nod-like chitin oligosaccharides during early embryogenesis., Semino CE, Specht CA, Raimondi A, Robbins PW., Proc Natl Acad Sci U S A. May 14, 1996; 93 (10): 4548-53.

Cells expressing the DG42 gene from early Xenopus embryos synthesize hyaluronan., Meyer MF, Kreil G., Proc Natl Acad Sci U S A. May 14, 1996; 93 (10): 4543-7.

Does DG42 synthesize hyaluronan or chitin?: A controversy about oligosaccharides in vertebrate development., Varki A., Proc Natl Acad Sci U S A. May 14, 1996; 93 (10): 4523-5.

Molecular cloning and characterization of a putative mouse hyaluronan synthase., Spicer AP, Augustine ML, McDonald JA., J Biol Chem. September 20, 1996; 271 (38): 23400-6.

Functional cloning of the cDNA for a human hyaluronan synthase., Shyjan AM, Heldin P, Butcher EC, Yoshino T, Briskin MJ., J Biol Chem. September 20, 1996; 271 (38): 23395-9.

Molecular identification of a putative human hyaluronan synthase., Watanabe K, Yamaguchi Y., J Biol Chem. September 20, 1996; 271 (38): 22945-8.

Yeast-derived recombinant DG42 protein of Xenopus can synthesize hyaluronan in vitro., DeAngelis PL, Achyuthan AM., J Biol Chem. September 27, 1996; 271 (39): 23657-60.

Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase., Spicer AP, Olson JS, McDonald JA., J Biol Chem. April 4, 1997; 272 (14): 8957-61.

Chromosomal localization of the human and mouse hyaluronan synthase genes., Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA., Genomics. May 1, 1997; 41 (3): 493-7.

An important developmental role for oligosaccharides during early embryogenesis of cyprinid fish., Bakkers J, Semino CE, Stroband H, Kijne JW, Robbins PW, Spaink HP., Proc Natl Acad Sci U S A. July 22, 1997; 94 (15): 7982-6.

Molecular cloning, expression, and characterization of the authentic hyaluronan synthase from group C Streptococcus equisimilis., Kumari K, Weigel PH., J Biol Chem. December 19, 1997; 272 (51): 32539-46.

Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family., Spicer AP, McDonald JA., J Biol Chem. January 23, 1998; 273 (4): 1923-32.              

Putative hyaluronan synthase mRNA are expressed in mouse skin and TGF-beta upregulates their expression in cultured human skin cells., Sugiyama Y, Shimada A, Sayo T, Sakai S, Inoue S., J Invest Dermatol. February 1, 1998; 110 (2): 116-21.

Enzymological characterization of recombinant xenopus DG42, a vertebrate hyaluronan synthase., Pummill PE, Achyuthan AM, DeAngelis PL., J Biol Chem. February 27, 1998; 273 (9): 4976-81.

The gene structure and promoter sequence of mouse hyaluronan synthase 1., Yamada Y, Itano N, Zako M, Yoshida M, Lenas P, Niimi A, Ueda M, Kimata K., Biochem J. March 15, 1998; 330 ( Pt 3) 1223-7.

Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning., Gawantka V, Pollet N, Delius H, Vingron M, Pfister R, Nitsch R, Blumenstock C, Niehrs C., Mech Dev. October 1, 1998; 77 (2): 95-141.                                                            

Hyaluronan synthase expression in bovine eyes., Usui T, Suzuki K, Kaji Y, Amano S, Miyata K, Heldin P, Yamashita H., Invest Ophthalmol Vis Sci. March 1, 1999; 40 (3): 563-7.

Expression pattern of a novel hyaluronidase during Xenopus embryogenesis., Hyde CE, Old RW., Mech Dev. April 1, 1999; 82 (1-2): 213-7.  

Relationship between hyaluronan production and metastatic potential of mouse mammary carcinoma cells., Itano N, Sawai T, Miyaishi O, Kimata K., Cancer Res. May 15, 1999; 59 (10): 2499-504.

Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties., Itano N, Sawai T, Yoshida M, Lenas P, Yamada Y, Imagawa M, Shinomura T, Hamaguchi M, Yoshida Y, Ohnuki Y, Miyauchi S, Spicer AP, McDonald JA, Kimata K., J Biol Chem. August 27, 1999; 274 (35): 25085-92.

Expression of hyaluronan synthase messenger ribonucleic acids and their induction by interleukin-1beta in human orbital fibroblasts: potential insight into the molecular pathogenesis of thyroid-associated ophthalmopathy., Kaback LA, Smith TJ., J Clin Endocrinol Metab. November 1, 1999; 84 (11): 4079-84.

Expression of recombinant hyaluronan synthase (HAS) isoforms in CHO cells reduces cell migration and cell surface CD44., Brinck J, Heldin P., Exp Cell Res. November 1, 1999; 252 (2): 342-51.

The effect of mechanical strain on hyaluronan metabolism in embryonic fibrocartilage cells., Dowthwaite GP, Ward AC, Flannely J, Suswillo RF, Flannery CR, Archer CW, Pitsillides AA., Matrix Biol. December 1, 1999; 18 (6): 523-32.

Increased synthesis of hyaluronate enhances motility of human melanoma cells., Ichikawa T, Itano N, Sawai T, Kimata K, Koganehira Y, Saida T, Taniguchi S., J Invest Dermatol. December 1, 1999; 113 (6): 935-9.

In vitro synthesis of hyaluronan by a single protein derived from mouse HAS1 gene and characterization of amino acid residues essential for the activity., Yoshida M, Itano N, Yamada Y, Kimata K., J Biol Chem. January 7, 2000; 275 (1): 497-506.

Synthesis of hyaluronan of distinctly different chain length is regulated by differential expression of Xhas1 and 2 during early development of Xenopus laevis., Köprunner M, Müllegger1 J, Lepperdinger G., Mech Dev. February 1, 2000; 90 (2): 275-8.

Expression of human hyaluronan synthases in response to external stimuli., Jacobson A, Brinck J, Briskin MJ, Spicer AP, Heldin P., Biochem J. May 15, 2000; 348 Pt 1 29-35.

Glucocorticoids induce a near-total suppression of hyaluronan synthase mRNA in dermal fibroblasts and in osteoblasts: a molecular mechanism contributing to organ atrophy., Zhang W, Watson CE, Liu C, Williams KJ, Werth VP., Biochem J. July 1, 2000; 349 (Pt 1): 91-7.

Differentiation of mesothelioma cells is influenced by the expression of proteoglycans., Dobra K, Andäng M, Syrokou A, Karamanos NK, Hjerpe A., Exp Cell Res. July 10, 2000; 258 (1): 12-22.

Expression regulation of hyaluronan synthase in corneal endothelial cells., Usui T, Amano S, Oshika T, Suzuki K, Miyata K, Araie M, Heldin P, Yamashita H., Invest Ophthalmol Vis Sci. October 1, 2000; 41 (11): 3261-7.

Differential regulation and expression of hyaluronan synthases in human articular chondrocytes, synovial cells and osteosarcoma cells., Recklies AD, White C, Melching L, Roughley PJ., Biochem J. February 15, 2001; 354 (Pt 1): 17-24.

Regulation of renal proximal tubular epithelial cell hyaluronan generation: implications for diabetic nephropathy., Jones S, Jones S, Phillips AO., Kidney Int. May 1, 2001; 59 (5): 1739-49.

Up-regulation of putative hyaluronan synthase mRNA by basic fibroblast growth factor and insulin-like growth factor-1 in human skin fibroblasts., Kuroda K, Utani A, Hamasaki Y, Shinkai H., J Dermatol Sci. June 1, 2001; 26 (2): 156-60.

Reticular erythematous mucinosis syndrome with an infiltration of factor XIIIa+ and hyaluronan synthase 2+ dermal dendrocytes., Tominaga A, Tajima S, Ishibashi A, Kimata K., Br J Dermatol. July 1, 2001; 145 (1): 141-5.

Regulation of hyaluronan synthase gene expression in human periodontal ligament cells by tumour necrosis factor-alpha, interleukin-1beta and interferon-gamma., Ijuin C, Ohno S, Tanimoto K, Honda K, Tanne K., Arch Oral Biol. August 1, 2001; 46 (8): 767-72.

Functional molecular mass of a vertebrate hyaluronan synthase as determined by radiation inactivation analysis., Pummill PE, Kempner ES, DeAngelis PL., J Biol Chem. October 26, 2001; 276 (43): 39832-5.

Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration., Itano N, Atsumi F, Sawai T, Yamada Y, Miyaishi O, Senga T, Hamaguchi M, Kimata K., Proc Natl Acad Sci U S A. March 19, 2002; 99 (6): 3609-14.

Mammalian hyaluronan synthases., Itano N, Kimata K., IUBMB Life. October 1, 2002; 54 (4): 195-9.

Characterization of hyaluronan synthase expression and hyaluronan synthesis in bone marrow mesenchymal progenitor cells: predominant expression of HAS1 mRNA and up-regulated hyaluronan synthesis in bone marrow cells derived from multiple myeloma patients., Calabro A, Oken MM, Hascall VC, Masellis AM., Blood. October 1, 2002; 100 (7): 2578-85.

Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta., Suzuki K, Yamamoto T, Usui T, Suzuki K, Heldin P, Yamashita H., Jpn J Ophthalmol. January 1, 2003; 47 (6): 557-64.

'Piggy-back' transport of Xenopus hyaluronan synthase (XHAS1) via the secretory pathway to the plasma membrane., Müllegger J, Rustom A, Kreil G, Gerdes HH, Lepperdinger G., Biol Chem. January 1, 2003; 384 (1): 175-82.

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