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Summary Expression Phenotypes Gene Literature (22) GO Terms (1) Nucleotides (44) Proteins (28) Interactants (37) Wiki
XB-GENEPAGE-994203

Papers associated with kcnk4



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Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation., Schroeter CB, Nelke C, Schewe M, Spohler L, Herrmann AM, Müntefering T, Huntemann N, Kuzikov M, Gribbon P, Albrecht S, Bock S, Hundehege P, Neelsen LC, Baukrowitz T, Seebohm G, Wünsch B, Bittner S, Ruck T, Budde T, Meuth SG., Biol Chem. March 28, 2023; 404 (4): 355-375.              

Physical basis for distinct basal and mechanically gated activity of the human K+ channel TRAAK., Rietmeijer RA, Sorum B, Li B, Brohawn SG., Neuron. September 15, 2021; 109 (18): 2902-2913.e4.            

Ultrasound activates mechanosensitive TRAAK K+ channels through the lipid membrane., Sorum B, Rietmeijer RA, Gopakumar K, Adesnik H, Brohawn SG., Proc Natl Acad Sci U S A. February 9, 2021; 118 (6):


The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier., Brohawn SG, Wang W, Handler A, Campbell EB, Schwarz JR, MacKinnon R., Elife. November 1, 2019; 8                     

Antiarrhythmic Properties of Ranolazine: Inhibition of Atrial Fibrillation Associated TASK-1 Potassium Channels., Ratte A, Wiedmann F, Kraft M, Katus HA, Schmidt C., Front Pharmacol. July 3, 2019; 10 1367.                                        

The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels., Rinné S, Kiper AK, Vowinkel KS, Ramírez D, Schewe M, Bedoya M, Aser D, Gensler I, Netter MF, Stansfeld PJ, Baukrowitz T, Gonzalez W, Decher N., Elife. February 26, 2019; 8                           

Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels., Pope L, Arrigoni C, Lou H, Bryant C, Gallardo-Godoy A, Renslo AR, Minor DL., ACS Chem Neurosci. December 19, 2018; 9 (12): 3153-3165.

Ultrasound modulates ion channel currents., Kubanek J, Shi J, Marsh J, Chen D, Deng C, Cui J., Sci Rep. April 26, 2016; 6 24170.                      

Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels., Goldstein M, Rinné S, Kiper AK, Ramírez D, Netter MF, Bustos D, Ortiz-Bonnin B, González W, Decher N., Sci Rep. January 22, 2016; 6 19492.              

Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel., Zhuo RG, Liu XY, Zhang SZ, Wei XL, Zheng JQ, Xu JP, Ma XY., Neuroscience. August 6, 2015; 300 85-93.

Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red., Braun G, Lengyel M, Enyedi P, Czirják G., Br J Pharmacol. April 1, 2015; 172 (7): 1728-38.

Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels., Lolicato M, Riegelhaupt PM, Arrigoni C, Clark KA, Minor DL., Neuron. December 17, 2014; 84 (6): 1198-212.

Bioelectric signaling regulates size in zebrafish fins., Perathoner S, Daane JM, Henrion U, Seebohm G, Higdon CW, Johnson SL, Nüsslein-Volhard C, Harris MP., PLoS Genet. January 1, 2014; 10 (1): e1004080.            

2-Aminoethoxydiphenyl borate activates the mechanically gated human KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK), and KCNK 10 (TREK-2)., Beltrán L, Beltrán M, Aguado A, Gisselmann G, Hatt H., Front Pharmacol. May 15, 2013; 4 63.      

Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains., Bagriantsev SN, Clark KA, Minor DL., EMBO J. August 1, 2012; 31 (15): 3297-308.            

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1., Rapedius M, Schmidt MR, Sharma C, Stansfeld PJ, Sansom MS, Baukrowitz T, Tucker SJ., Channels (Austin). January 1, 2012; 6 (6): 473-8.      

Inhibitory effects of polyunsaturated fatty acids on Kv4/KChIP potassium channels., Boland LM, Drzewiecki MM, Timoney G, Casey E., Am J Physiol Cell Physiol. May 1, 2009; 296 (5): C1003-14.

Zinc and mercuric ions distinguish TRESK from the other two-pore-domain K+ channels., Czirják G, Enyedi P., Mol Pharmacol. March 1, 2006; 69 (3): 1024-32.

PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels., Lopes CM, Rohács T, Czirják G, Balla T, Enyedi P, Logothetis DE., J Physiol. April 1, 2005; 564 (Pt 1): 117-29.

Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human two-pore K+ channel gene KCNK4. Chromosomal localization, tissue distribution and functional expression., Ozaita A, Vega-Saenz de Miera E., Brain Res Mol Brain Res. June 15, 2002; 102 (1-2): 18-27.

The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 and TRAAK., Meadows HJ, Chapman CG, Duckworth DM, Kelsell RE, Murdock PR, Nasir S, Rennie G, Randall AD., Dev Biol. February 16, 2001; 892 (1): 94-101.

A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids., Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M., EMBO J. June 15, 1998; 17 (12): 3297-308.

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