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Summary Expression Phenotypes Gene Literature (42) GO Terms (4) Nucleotides (334) Proteins (83) Interactants (308) Wiki

Papers associated with slc7a8

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2 paper(s) referencing morpholinos

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From zebrafish to human: A comparative approach to elucidate the role of the thyroid hormone transporter MCT8 during brain development., Vancamp P, Darras VM., Gen Comp Endocrinol. September 1, 2018; 265 219-229.

Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids., Hinz KM, Neef D, Rutz C, Furkert J, Köhrle J, Schülein R, Krause G., Mol Cell Endocrinol. March 5, 2017; 443 163-174.

Specific transport of 3-fluoro-l-α-methyl-tyrosine by LAT1 explains its specificity to malignant tumors in imaging., Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, Kaira K, Oriuchi N, Nagamori S, Kanai Y., Cancer Sci. March 1, 2016; 107 (3): 347-52.        

Involvement of the L-Type Amino Acid Transporter Lat2 in the Transport of 3,3'-Diiodothyronine across the Plasma Membrane., Kinne A, Wittner M, Wirth EK, Hinz KM, Schülein R, Köhrle J, Krause G., Eur Thyroid J. September 1, 2015; 4 (Suppl 1): 42-50.

Structural insights into thyroid hormone transport mechanisms of the L-type amino acid transporter 2., Hinz KM, Meyer K, Kinne A, Schülein R, Köhrle J, Krause G., Mol Endocrinol. June 1, 2015; 29 (6): 933-42.

Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2., Wongthai P, Hagiwara K, Miyoshi Y, Wiriyasermkul P, Wei L, Ohgaki R, Kato I, Hamase K, Nagamori S, Kanai Y., Cancer Sci. March 1, 2015; 106 (3): 279-86.            

The molecular mechanism of intestinal levodopa absorption and its possible implications for the treatment of Parkinson's disease., Camargo SM, Vuille-dit-Bille RN, Mariotta L, Ramadan T, Huggel K, Singer D, Götze O, Verrey F., J Pharmacol Exp Ther. October 1, 2014; 351 (1): 114-23.

Monoterpene glycoside ESK246 from Pittosporum targets LAT3 amino acid transport and prostate cancer cell growth., Wang Q, Grkovic T, Font J, Bonham S, Pouwer RH, Bailey CG, Moran AM, Ryan RM, Rasko JE, Jormakka M, Quinn RJ, Holst J., ACS Chem Biol. June 20, 2014; 9 (6): 1369-76.          

The Wnt/JNK signaling target gene alcam is required for embryonic kidney development., Cizelsky W, Tata A, Kühl M, Kühl SJ., Development. May 1, 2014; 141 (10): 2064-74.          

Kinetic analyses of trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid transport in Xenopus laevis oocytes expressing human ASCT2 and SNAT2., Okudaira H, Nakanishi T, Oka S, Kobayashi M, Tamagami H, Schuster DM, Goodman MM, Shirakami Y, Tamai I, Kawai K., Nucl Med Biol. July 1, 2013; 40 (5): 670-5.

Exon capture and bulk segregant analysis: rapid discovery of causative mutations using high-throughput sequencing., del Viso F, Bhattacharya D, Kong Y, Gilchrist MJ, Khokha MK., BMC Genomics. November 21, 2012; 13 649.                  

Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells., Oropeza D, Horb M., Genesis. March 1, 2012; 50 (3): 271-85.                        

The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps., Drews C, Senkel S, Ryffel GU., BMC Dev Biol. January 31, 2011; 11 5.              

Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties., Reynolds B, Roversi P, Laynes R, Kazi S, Boyd CA, Goberdhan DC., Biochem J. May 27, 2009; 420 (3): 363-72.

Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters., Morimoto E, Kanai Y, Kim DK, Chairoungdua A, Choi HW, Wempe MF, Anzai N, Endou H., J Pharmacol Sci. December 1, 2008; 108 (4): 505-16.

Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2., del Amo EM, Urtti A, Yliperttula M., Eur J Pharm Sci. October 2, 2008; 35 (3): 161-74.

Organization of the pronephric kidney revealed by large-scale gene expression mapping., Raciti D, Reggiani L, Geffers L, Jiang Q, Bacchion F, Subrizi AE, Clements D, Tindal C, Davidson DR, Kaissling B, Brändli AW., Genome Biol. January 1, 2008; 9 (5): R84.                                                                        

Characterization of amino acid transport system L in HTB-41 human salivary gland epidermoid carcinoma cells., Park NS, Kim SG, Kim HK, Moon SY, Kim CS, Cho SH, Kanai Y, Endou H, Kim do K., Anticancer Res. January 1, 2008; 28 (5A): 2649-55.

Recycling of aromatic amino acids via TAT1 allows efflux of neutral amino acids via LAT2-4F2hc exchanger., Ramadan T, Camargo SM, Herzog B, Bordin M, Pos KM, Verrey F., Pflugers Arch. June 1, 2007; 454 (3): 507-16.

Functional characterization of two S-nitroso-L-cysteine transporters, which mediate movement of NO equivalents into vascular cells., Li S, Whorton AR., Am J Physiol Cell Physiol. April 1, 2007; 292 (4): C1263-71.

Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway., Ramadan T, Camargo SM, Summa V, Hunziker P, Chesnov S, Pos KM, Verrey F., J Cell Physiol. March 1, 2006; 206 (3): 771-9.

Differential expression and functional characterization of system L amino acid transporters in human normal osteoblast cells and osteogenic sarcoma cells., Kim SG, Kim HH, Kim HK, Kim CH, Chun HS, Kanai Y, Endou H, Kim do K., Anticancer Res. January 1, 2006; 26 (3A): 1989-96.

Mutation of the 4F2 heavy-chain carboxy terminus causes y+ LAT2 light-chain dysfunction., Chubb S, Kingsland AL, Bröer A, Bröer S., Mol Membr Biol. January 1, 2006; 23 (3): 255-67.

Amino acid cotransporter SLC3A2 is selectively expressed in the early proximal segment of Xenopus pronephric kidney nephrons., Zhou X, Vize PD., Gene Expr Patterns. August 1, 2005; 5 (6): 774-7.    

Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols., Li S, Whorton AR., J Biol Chem. May 20, 2005; 280 (20): 20102-10.

Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule., Park SY, Kim JK, Kim IJ, Choi BK, Jung KY, Lee S, Park KJ, Chairoungdua A, Kanai Y, Endou H, Kim DK., Arch Pharm Res. April 1, 2005; 28 (4): 421-32.

Identification of LAT4, a novel amino acid transporter with system L activity., Bodoy S, Martín L, Zorzano A, Palacín M, Estévez R, Bertran J., J Biol Chem. March 25, 2005; 280 (12): 12002-11.

Temporal regulation of global gene expression and cellular morphology in Xenopus kidney cells in response to clinorotation., Kitamoto J, Fukui A, Asashima M., Adv Space Res. January 1, 2005; 35 (9): 1654-61.

Proximo-distal specialization of epithelial transport processes within the Xenopus pronephric kidney tubules., Zhou X, Zhou X, Vize PD., Dev Biol. July 15, 2004; 271 (2): 322-38.                                  

The dopamine precursor L-dihydroxyphenylalanine is transported by the amino acid transporters rBAT and LAT2 in renal cortex., Quiñones H, Collazo R, Moe OW., Am J Physiol Renal Physiol. July 1, 2004; 287 (1): F74-80.

Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters., Babu E, Kanai Y, Chairoungdua A, Kim DK, Iribe Y, Tangtrongsup S, Jutabha P, Li Y, Ahmed N, Sakamoto S, Anzai N, Nagamori S, Endou H., J Biol Chem. October 31, 2003; 278 (44): 43838-45.

Glutamine efflux from astrocytes is mediated by multiple pathways., Deitmer JW, Bröer A, Bröer S., J Neurochem. October 1, 2003; 87 (1): 127-35.

Asymmetry of glutamine transporters in cultured neural cells., Heckel T, Bröer A, Wiesinger H, Lang F, Bröer S., Neurochem Int. January 1, 2003; 43 (4-5): 289-98.

Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2., Simmons-Willis TA, Koh AS, Clarkson TW, Ballatori N., Biochem J. October 1, 2002; 367 (Pt 1): 239-46.

Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells., Kim DK, Kanai Y, Choi HW, Tangtrongsup S, Chairoungdua A, Babu E, Tachampa K, Anzai N, Iribe Y, Endou H., Biochim Biophys Acta. September 20, 2002; 1565 (1): 112-21.

Activation of system L heterodimeric amino acid exchangers by intracellular substrates., Meier C, Ristic Z, Klauser S, Verrey F., EMBO J. February 15, 2002; 21 (4): 580-9.

Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains., Bröer A, Friedrich B, Wagner CA, Fillon S, Ganapathy V, Lang F, Bröer S., Biochem J. May 1, 2001; 355 (Pt 3): 725-31.

Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids., Fukasawa Y, Segawa H, Kim JY, Chairoungdua A, Kim DK, Matsuo H, Cha SH, Endou H, Kanai Y., J Biol Chem. March 31, 2000; 275 (13): 9690-8.

LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine., Rossier G, Meier C, Bauch C, Summa V, Sordat B, Verrey F, Kühn LC., J Biol Chem. December 3, 1999; 274 (49): 34948-54.

SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family., Bassi MT, Sperandeo MP, Incerti B, Bulfone A, Pepe A, Surace EM, Gattuso C, De Grandi A, Buoninconti A, Riboni M, Manzoni M, Andria G, Ballabio A, Borsani G, Sebastio G., Genomics. December 1, 1999; 62 (2): 297-303.

Cloning and expression of a b(0,+)-like amino acid transporter functioning as a heterodimer with 4F2hc instead of rBAT. A new candidate gene for cystinuria., Rajan DP, Kekuda R, Huang W, Wang H, Devoe LD, Leibach FH, Prasad PD, Ganapathy V., J Biol Chem. October 8, 1999; 274 (41): 29005-10.

[Amino acid transporter molecule as a drug target]., Endou H, Kanai Y., Nihon Yakurigaku Zasshi. October 1, 1999; 114 Suppl 1 11P-16P.

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