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Summary Expression Phenotypes Gene Literature (37) GO Terms (7) Nucleotides (101) Proteins (35) Interactants (47) Wiki
XB-GENEPAGE-993671

Papers associated with panx1



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Pannexins, a family of gap junction proteins expressed in brain., Bruzzone R, Hormuzdi SG, Barbe MT, Herb A, Monyer H., Proc Natl Acad Sci U S A. November 11, 2003; 100 (23): 13644-9.

Identification of a potential regulator of the gap junction protein pannexin1., Bunse S, Haghika A, Zoidl G, Dermietzel R., Cell Commun Adhes. January 1, 2005; 12 (5-6): 231-6.

Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes., Bruzzone R, Barbe MT, Jakob NJ, Monyer H., J Neurochem. March 1, 2005; 92 (5): 1033-43.

Xenopus connexins: how frogs bridge the gap., de Boer TP, van der Heyden MA., Differentiation. September 1, 2005; 73 (7): 330-40.

Pannexin1 and Pannexin2 expression in the developing and mature rat brain., Vogt A, Hormuzdi SG, Monyer H., Brain Res Mol Brain Res. November 18, 2005; 141 (1): 113-20.

Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium., Locovei S, Wang J, Dahl G., FEBS Lett. January 9, 2006; 580 (1): 239-44.

Pannexin 1 in erythrocytes: function without a gap., Locovei S, Bao L, Dahl G., Proc Natl Acad Sci U S A. May 16, 2006; 103 (20): 7655-9.

Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex., Locovei S, Scemes E, Qiu F, Spray DC, Dahl G., FEBS Lett. February 6, 2007; 581 (3): 483-8.

Localization of the pannexin1 protein at postsynaptic sites in the cerebral cortex and hippocampus., Zoidl G, Petrasch-Parwez E, Ray A, Meier C, Bunse S, Habbes HW, Dahl G, Dermietzel R., Neuroscience. April 25, 2007; 146 (1): 9-16.

Innexins form two types of channels., Bao L, Samuels S, Locovei S, Macagno ER, Muller KJ, Dahl G., FEBS Lett. December 11, 2007; 581 (29): 5703-8.

Trafficking dynamics of glycosylated pannexin 1 proteins., Boassa D, Qiu F, Dahl G, Sosinsky G., Cell Commun Adhes. May 1, 2008; 15 (1): 119-32.

Probenecid, a gout remedy, inhibits pannexin 1 channels., Silverman W, Locovei S, Dahl G., Am J Physiol Cell Physiol. September 1, 2008; 295 (3): C761-7.

P2X7 receptor-Pannexin1 complex: pharmacology and signaling., Iglesias R, Locovei S, Roque A, Alberto AP, Dahl G, Spray DC, Scemes E., Am J Physiol Cell Physiol. September 1, 2008; 295 (3): C752-60.

A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP., Qiu F, Dahl G., Am J Physiol Cell Physiol. February 1, 2009; 296 (2): C250-5.

The pannexin 1 channel activates the inflammasome in neurons and astrocytes., Silverman WR, de Rivero Vaccari JP, Locovei S, Qiu F, Carlsson SK, Scemes E, Keane RW, Dahl G., J Biol Chem. July 3, 2009; 284 (27): 18143-51.

Pannexin 1 contributes to ATP release in airway epithelia., Ransford GA, Fregien N, Qiu F, Dahl G, Conner GE, Salathe M., Am J Respir Cell Mol Biol. November 1, 2009; 41 (5): 525-34.

The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials., Bunse S, Locovei S, Schmidt M, Qiu F, Zoidl G, Dahl G, Dermietzel R., FEBS J. November 1, 2009; 276 (21): 6258-70.

Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other., Ambrosi C, Gassmann O, Pranskevich JN, Boassa D, Smock A, Wang J, Dahl G, Steinem C, Sosinsky GE., J Biol Chem. August 6, 2010; 285 (32): 24420-31.                    

SCAM analysis of Panx1 suggests a peculiar pore structure., Wang J, Dahl G., J Gen Physiol. November 1, 2010; 136 (5): 515-27.                  

Intracellular cysteine 346 is essentially involved in regulating Panx1 channel activity., Bunse S, Schmidt M, Prochnow N, Zoidl G, Dermietzel R., J Biol Chem. December 3, 2010; 285 (49): 38444-52.

Pannexin 1 constitutes the large conductance cation channel of cardiac myocytes., Kienitz MC, Bender K, Dermietzel R, Pott L, Zoidl G., J Biol Chem. January 7, 2011; 286 (1): 290-8.

Single cysteines in the extracellular and transmembrane regions modulate pannexin 1 channel function., Bunse S, Schmidt M, Hoffmann S, Engelhardt K, Zoidl G, Dermietzel R., J Membr Biol. November 1, 2011; 244 (1): 21-33.

The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1., Wang J, Jackson DG, Dahl G., J Gen Physiol. May 1, 2013; 141 (5): 649-56.              

ATP and potassium ions: a deadly combination for astrocytes., Jackson DG, Wang J, Keane RW, Scemes E, Dahl G., Sci Rep. February 26, 2014; 4 4576.                  

Connexin hemichannel and pannexin channel electrophysiology: how do they differ?, Patel D, Zhang X, Veenstra RD., FEBS Lett. April 17, 2014; 588 (8): 1372-8.

The membrane protein Pannexin1 forms two open-channel conformations depending on the mode of activation., Wang J, Ambrosi C, Qiu F, Jackson DG, Sosinsky G, Dahl G., Sci Signal. July 22, 2014; 7 (335): ra69.

Activation, permeability, and inhibition of astrocytic and neuronal large pore (hemi)channels., Hansen DB, Ye ZC, Calloe K, Braunstein TH, Hofgaard JP, Ransom BR, Nielsen MS, MacAulay N., J Biol Chem. September 19, 2014; 289 (38): 26058-26073.

Effects on channel properties and induction of cell death induced by c-terminal truncations of pannexin1 depend on domain length., Engelhardt K, Schmidt M, Tenbusch M, Dermietzel R., J Membr Biol. April 1, 2015; 248 (2): 285-94.

Dual Oxidase 2 (Duox2) Regulates Pannexin 1-mediated ATP Release in Primary Human Airway Epithelial Cells via Changes in Intracellular pH and Not H2O2 Production., Krick S, Wang J, St-Pierre M, Gonzalez C, Dahl G, Salathe M., J Biol Chem. March 18, 2016; 291 (12): 6423-32.

CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes., Ma Z, Taruno A, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff H, Payne R, Demuro A, Parker I, Mitchell CH, Henao-Mejia J, Tanis JE, Matsumoto I, Tordoff MG, Foskett JK., Neuron. May 2, 2018; 98 (3): 547-561.e10.                                

Pannexin1: a multifunction and multiconductance and/or permeability membrane channel., Wang J, Dahl G., Am J Physiol Cell Physiol. September 1, 2018; 315 (3): C290-C299.

Cationic control of Panx1 channel function., Wang J, Jackson DG, Dahl G., Am J Physiol Cell Physiol. September 1, 2018; 315 (3): C279-C289.

Pannexin 1 activation and inhibition is permeant-selective., Nielsen BS, Toft-Bertelsen TL, Lolansen SD, Anderson CL, Nielsen MS, Thompson RJ, MacAulay N., J Physiol. January 1, 2020; 598 (2): 361-379.

The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition., Michalski K, Syrjanen JL, Henze E, Kumpf J, Furukawa H, Kawate T., Elife. February 12, 2020; 9                     

ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels., Narahari AK, Kreutzberger AJ, Gaete PS, Chiu YH, Leonhardt SA, Medina CB, Jin X, Oleniacz PW, Kiessling V, Barrett PQ, Ravichandran KS, Yeager M, Contreras JE, Tamm LK, Bayliss DA., Elife. January 7, 2021; 10


Homozygous variants in PANX1 cause human oocyte death and female infertility., Wang W, Qu R, Dou Q, Wu F, Wang W, Chen B, Mu J, Zhang Z, Zhao L, Zhou Z, Dong J, Zeng Y, Liu R, Du J, Zhu S, Li Q, He L, Jin L, Wang L, Sang Q., Eur J Hum Genet. September 1, 2021; 29 (9): 1396-1404.

Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling., Whyte-Fagundes P, Taskina D, Safarian N, Zoidl C, Carlen PL, Donaldson LW, Zoidl GR., Commun Biol. May 18, 2022; 5 (1): 472.

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