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Summary Expression Phenotypes Gene Literature (103) GO Terms (6) Nucleotides (101) Proteins (74) Interactants (240) Wiki
XB-GENEPAGE-478442

Papers associated with nedd4



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Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination., Staub O, Gautschi I, Ishikawa T, Breitschopf K, Ciechanover A, Schild L, Rotin D., EMBO J. November 3, 1997; 16 (21): 6325-36.

Molecular cloning of Nedd4 from Xenopus laevis., Rebhun JF, Pratt JH., DNA Seq. January 1, 1998; 9 (5-6): 295-306.

Inhibition of the epithelial Na+ channel by interaction of Nedd4 with a PY motif deleted in Liddle's syndrome., Goulet CC, Volk KA, Adams CM, Prince LS, Stokes JB, Snyder PM., J Biol Chem. November 6, 1998; 273 (45): 30012-7.

Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome., Abriel H, Loffing J, Rebhun JF, Pratt JH, Schild L, Horisberger JD, Rotin D, Staub O., J Clin Invest. March 1, 1999; 103 (5): 667-73.

Cystic fibrosis transmembrane conductance regulator inhibits epithelial Na+ channels carrying Liddle's syndrome mutations., Hopf A, Schreiber R, Mall M, Greger R, Kunzelmann K., J Biol Chem. May 14, 1999; 274 (20): 13894-9.

Regulation of the cardiac voltage-gated Na+ channel (H1) by the ubiquitin-protein ligase Nedd4., Abriel H, Kamynina E, Horisberger JD, Staub O., FEBS Lett. January 28, 2000; 466 (2-3): 377-80.

Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits., Farr TJ, Coddington-Lawson SJ, Snyder PM, McDonald FJ., Biochem J. February 1, 2000; 345 Pt 3 503-9.

Regulation of sgk by aldosterone and its effects on the epithelial Na(+) channel., Shigaev A, Asher C, Latter H, Garty H, Reuveny E., Am J Physiol Renal Physiol. April 1, 2000; 278 (4): F613-9.

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel., Kamynina E, Debonneville C, Bens M, Vandewalle A, Staub O., FASEB J. January 1, 2001; 15 (1): 204-214.

Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4., Snyder PM, Olson DR, McDonald FJ, Bucher DB., J Biol Chem. July 27, 2001; 276 (30): 28321-6.

Liddle's syndrome: a novel mouse Nedd4 isoform regulates the activity of the epithelial Na(+) channel., Kamynina E, Debonneville C, Hirt RP, Staub O., Kidney Int. August 1, 2001; 60 (2): 466-71.

Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation., Kamynina E, Tauxe C, Staub O., Am J Physiol Renal Physiol. September 1, 2001; 281 (3): F469-77.

Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression., Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, Münster C, Chraïbi A, Pratt JH, Horisberger JD, Pearce D, Loffing J, Staub O., EMBO J. December 17, 2001; 20 (24): 7052-9.

Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation., Shi H, Asher C, Chigaev A, Yung Y, Reuveny E, Seger R, Garty H., J Biol Chem. April 19, 2002; 277 (16): 13539-47.

Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein., Konstas AA, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, Korbmacher C, Kumar S., J Biol Chem. August 16, 2002; 277 (33): 29406-16.

Casein kinase 2 specifically binds to and phosphorylates the carboxy termini of ENaC subunits., Shi H, Asher C, Yung Y, Kligman L, Reuveny E, Seger R, Garty H., Eur J Biochem. September 1, 2002; 269 (18): 4551-8.

SGK1: aldosterone-induced relay of Na+ transport regulation in distal kidney nephron cells., Verrey F, Loffing J, Zecevic M, Heitzmann D, Staub O., Cell Physiol Biochem. January 1, 2003; 13 (1): 21-8.

The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels., Fotia AB, Dinudom A, Shearwin KE, Koch JP, Korbmacher C, Cook DI, Kumar S., FASEB J. January 1, 2003; 17 (1): 70-2.

Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A., Boehmer C, Wilhelm V, Palmada M, Wallisch S, Henke G, Brinkmeier H, Cohen P, Pieske B, Lang F., Cardiovasc Res. March 15, 2003; 57 (4): 1079-84.

Syntaxin 1A regulates ENaC via domain-specific interactions., Condliffe SB, Carattino MD, Frizzell RA, Zhang H., J Biol Chem. April 11, 2003; 278 (15): 12796-804.

Properties and regulation of glutamine transporter SN1 by protein kinases SGK and PKB., Boehmer C, Okur F, Setiawan I, Bröer S, Lang F., Biochem Biophys Res Commun. June 20, 2003; 306 (1): 156-62.

Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B., Boehmer C, Henke G, Schniepp R, Palmada M, Rothstein JD, Bröer S, Lang F., J Neurochem. September 1, 2003; 86 (5): 1181-8.

Differential expression and localisation of WWP1, a Nedd4-like protein, in epithelia., Malbert-Colas L, Fay M, Cluzeaud F, Blot-Chabaud M, Farman N, Dhermy D, Lecomte MC., Pflugers Arch. October 1, 2003; 447 (1): 35-43.

Participation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel., Debonneville C, Staub O., Mol Cell Biol. March 1, 2004; 24 (6): 2397-409.

Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB., Dieter M, Palmada M, Rajamanickam J, Aydin A, Busjahn A, Boehmer C, Luft FC, Lang F., Obes Res. May 1, 2004; 12 (5): 862-70.

Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1., Henke G, Maier G, Wallisch S, Boehmer C, Lang F., J Cell Physiol. May 1, 2004; 199 (2): 194-9.

Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid-dependent kinase 1., Palmada M, Dieter M, Speil A, Böhmer C, Mack AF, Wagner HJ, Klingel K, Kandolf R, Murer H, Biber J, Closs EI, Lang F., Am J Physiol Gastrointest Liver Physiol. July 1, 2004; 287 (1): G143-50.

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2., Fotia AB, Ekberg J, Adams DJ, Cook DI, Poronnik P, Kumar S., J Biol Chem. July 9, 2004; 279 (28): 28930-5.

N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking., Shearwin-Whyatt LM, Brown DL, Wylie FG, Stow JL, Kumar S., J Cell Sci. July 15, 2004; 117 (Pt 16): 3679-89.

A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes., Fouladkou F, Alikhani-Koopaei R, Vogt B, Flores SY, Malbert-Colas L, Lecomte MC, Loffing J, Frey FJ, Frey BM, Staub O., Am J Physiol Renal Physiol. September 1, 2004; 287 (3): F550-61.

Serum and glucocorticoid inducible kinases functionally regulate ClC-2 channels., Palmada M, Dieter M, Boehmer C, Waldegger S, Lang F., Biochem Biophys Res Commun. September 3, 2004; 321 (4): 1001-6.

A novel pathway of epithelial sodium channel activation involves a serum- and glucocorticoid-inducible kinase consensus motif in the C terminus of the channel's alpha-subunit., Diakov A, Korbmacher C., J Biol Chem. September 10, 2004; 279 (37): 38134-42.

Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases., Embark HM, Böhmer C, Palmada M, Rajamanickam J, Wyatt AW, Wallisch S, Capasso G, Waldegger P, Seyberth HW, Waldegger S, Lang F., Kidney Int. November 1, 2004; 66 (5): 1918-25.

Stimulation of the EAAT4 glutamate transporter by SGK protein kinase isoforms and PKB., Böhmer C, Philippin M, Rajamanickam J, Mack A, Broer S, Palmada M, Lang F., Biochem Biophys Res Commun. November 26, 2004; 324 (4): 1242-8.

Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells., Hryciw DH, Ekberg J, Lee A, Lensink IL, Kumar S, Guggino WB, Cook DI, Pollock CA, Poronnik P., J Biol Chem. December 31, 2004; 279 (53): 54996-5007.

14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase., Ichimura T, Yamamura H, Sasamoto K, Tominaga Y, Taoka M, Kakiuchi K, Shinkawa T, Takahashi N, Shimada S, Isobe T., J Biol Chem. April 1, 2005; 280 (13): 13187-94.

Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes., Baltaev R, Strutz-Seebohm N, Korniychuk G, Myssina S, Lang F, Seebohm G., Pflugers Arch. April 1, 2005; 450 (1): 26-33.

Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells., Carattino MD, Edinger RS, Grieser HJ, Wise R, Neumann D, Schlattner U, Johnson JP, Kleyman TR, Hallows KR., J Biol Chem. May 6, 2005; 280 (18): 17608-16.

Role of Nedd4-2 and polyubiquitination in epithelial sodium channel degradation in untransfected renal A6 cells expressing endogenous ENaC subunits., Malik B, Yue Q, Yue G, Chen XJ, Price SR, Mitch WE, Eaton DC., Am J Physiol Renal Physiol. July 1, 2005; 289 (1): F107-16.

Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells., Flores SY, Loffing-Cueni D, Kamynina E, Daidié D, Gerbex C, Chabanel S, Dudler J, Loffing J, Staub O., J Am Soc Nephrol. August 1, 2005; 16 (8): 2279-87.

Nedd4-2 isoforms differentially associate with ENaC and regulate its activity., Itani OA, Stokes JB, Thomas CP., Am J Physiol Renal Physiol. August 1, 2005; 289 (2): F334-46.

Progesterone down-regulates the open probability of the amiloride-sensitive epithelial sodium channel via a Nedd4-2-dependent mechanism., Michlig S, Harris M, Loffing J, Rossier BC, Firsov D., J Biol Chem. November 18, 2005; 280 (46): 38264-70.

Stimulation of the epithelial sodium channel (ENaC) by cAMP involves putative ERK phosphorylation sites in the C termini of the channel's beta- and gamma-subunit., Yang LM, Rinke R, Korbmacher C., J Biol Chem. April 14, 2006; 281 (15): 9859-68.

Post-translational regulation of EAAT2 function by co-expressed ubiquitin ligase Nedd4-2 is impacted by SGK kinases., Boehmer C, Palmada M, Rajamanickam J, Schniepp R, Amara S, Lang F., J Neurochem. May 1, 2006; 97 (4): 911-21.

14-3-3 Mediates phosphorylation-dependent inhibition of the interaction between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels., Nagaki K, Yamamura H, Shimada S, Saito T, Hisanaga S, Taoka M, Isobe T, Ichimura T., Biochemistry. May 30, 2006; 45 (21): 6733-40.

Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition., Rauh R, Dinudom A, Fotia AB, Paulides M, Kumar S, Korbmacher C, Cook DI., Pflugers Arch. June 1, 2006; 452 (3): 290-9.

AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2., Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR., J Biol Chem. September 8, 2006; 281 (36): 26159-69.

Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2., Hatanaka T, Hatanaka Y, Setou M., J Biol Chem. November 24, 2006; 281 (47): 35922-30.

Early aldosterone-induced gene product regulates the epithelial sodium channel by deubiquitylation., Fakitsas P, Adam G, Daidié D, van Bemmelen MX, Fouladkou F, Patrignani A, Wagner U, Warth R, Camargo SM, Staub O, Verrey F., J Am Soc Nephrol. April 1, 2007; 18 (4): 1084-92.

Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2., Ekberg J, Schuetz F, Boase NA, Conroy SJ, Manning J, Kumar S, Poronnik P, Adams DJ., J Biol Chem. April 20, 2007; 282 (16): 12135-42.

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