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Summary Expression Phenotypes Gene Literature (156) GO Terms (14) Nucleotides (355) Proteins (94) Interactants (577) Wiki
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Papers associated with pam



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Disruption of an amino acid transporter LHT1 leads to growth inhibition and low yields in rice., Wang X, Yang G, Shi M, Hao D, Wei Q, Wang Z, Fu S, Su Y, Xia J., BMC Plant Biol. June 20, 2019; 19 (1): 268.          

Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model., Sun LL, Yang TY, Wei NN, Lu W, Jiao WX, Zhou QQ, Miao YZ, Gao Q, Wang XT, Sun Q, Wang K., Acta Pharmacol Sin. June 1, 2019; 40 (6): 737-745.

Allosteric Agonism of α7 Nicotinic Acetylcholine Receptors: Receptor Modulation Outside the Orthosteric Site., Gulsevin A, Papke RL, Stokes C, Garai S, Thakur GA, Quadri M, Horenstein NA., Mol Pharmacol. June 1, 2019; 95 (6): 606-614.

Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1., Harnoš J, Cañizal MCA, Jurásek M, Kumar J, Holler C, Schambony A, Hanáková K, Bernatík O, Zdráhal Z, Gömöryová K, Gybeľ T, Radaszkiewicz TW, Kravec M, Trantírek L, Ryneš J, Dave Z, Fernández-Llamazares AI, Vácha R, Tripsianes K, Hoffmann C, Bryja V., Nat Commun. April 18, 2019; 10 (1): 1804.                  

Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors., Choudhary S, Marjianović DS, Wong CR, Zhang X, Abongwa M, Coats JR, Trailović SM, Martin RJ, Robertson AP., Int J Parasitol Drugs Drug Resist. April 1, 2019; 9 44-53.                

Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice., Li Y, Sun L, Yang T, Jiao W, Tang J, Huang X, Huang Z, Meng Y, Luo L, Wang X, Bian X, Zhang F, Wang K, Sun Q., J Med Chem. January 10, 2019; 62 (1): 159-173.

Macroscopic and Microscopic Activation of α7 Nicotinic Acetylcholine Receptors by the Structurally Unrelated Allosteric Agonist-Positive Allosteric Modulators (ago-PAMs) B-973B and GAT107., Quadri M, Garai S, Thakur GA, Stokes C, Gulsevin A, Horenstein NA, Papke RL., Mol Pharmacol. January 1, 2019; 95 (1): 43-61.

The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators., Sapkota K, Dore K, Tang K, Irvine M, Fang G, Burnell ES, Malinow R, Jane DE, Monaghan DT., Biochem Pharmacol. January 1, 2019; 159 140-153.

des-Formylflustrabromine (dFBr): A Structure-Activity Study on Its Ability To Potentiate the Action of Acetylcholine at α4β2 Nicotinic Acetylcholine Receptors., Dukat M, Jain A, German N, Ferrara-Pontoriero R, Huang Y, Ma Y, Schulte MK, Glennon RA., ACS Chem Neurosci. December 19, 2018; 9 (12): 2984-2996.

The Antinociceptive and Anti-Inflammatory Properties of the α7 nAChR Weak Partial Agonist p-CF3N,N-diethyl-N'-phenylpiperazine., Quadri M, Bagdas D, Toma W, Stokes C, Horenstein NA, Damaj MI, Papke RL., J Pharmacol Exp Ther. November 1, 2018; 367 (2): 203-214.

B-973, a Novel α7 nAChR Ago-PAM: Racemic and Asymmetric Synthesis, Electrophysiological Studies, and in Vivo Evaluation., Garai S, Raja KS, Papke RL, Deschamps JR, Damaj MI, Thakur GA., ACS Med Chem Lett. October 11, 2018; 9 (11): 1144-1148.

Molecular function of the novel α7β2 nicotinic receptor., Nielsen BE, Minguez T, Bermudez I, Bouzat C., Cell Mol Life Sci. July 1, 2018; 75 (13): 2457-2471.

CRISPR/Cas9-mediated efficient and precise targeted integration of donor DNA harboring double cleavage sites in Xenopus tropicalis., Mao CZ, Zheng L, Zhou YM, Wu HY, Xia JB, Liang CQ, Guo XF, Peng WT, Zhao H, Cai WB, Kim SK, Park KS, Cai DQ, Qi XF., FASEB J. June 13, 2018; fj201800093.              

Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states., Papke RL, Stokes C, Damaj MI, Thakur GA, Manther K, Treinin M, Bagdas D, Kulkarni AR, Horenstein NA., Br J Pharmacol. June 1, 2018; 175 (11): 1838-1854.

Cerebellar α6 -subunit-containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders., Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mouri A, Chen LC, Treven M, Mamiya T, Fan PC, Knutson DE, Witzigmann C, Cook J, Sieghart W, Nabeshima T., Br J Pharmacol. June 1, 2018; 175 (12): 2414-2427.

The atypical mitogen-activated protein kinase ERK3 is essential for establishment of epithelial architecture., Takahashi C, Miyatake K, Kusakabe M, Nishida E., J Biol Chem. June 1, 2018; 293 (22): 8342-8361.                                      

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups., Perszyk R, Katzman BM, Kusumoto H, Kell SA, Epplin MP, Tahirovic YA, Moore RL, Menaldino D, Burger P, Liotta DC, Traynelis SF., Elife. May 24, 2018; 7                                                                         

Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors., Olander ER, Madjroh N, Bunch L, Söderhielm PC, Jensen AA., Biochem Pharmacol. April 1, 2018; 150 305-319.

Divergent axial morphogenesis and early shh expression in vertebrate prospective floor plate., Kremnyov S, Henningfeld K, Viebahn C, Tsikolia N., Evodevo. January 31, 2018; 9 4.                    

LY2087101 and dFBr share transmembrane binding sites in the (α4)3(β2)2 Nicotinic Acetylcholine Receptor., Deba F, Ali HI, Tairu A, Ramos K, Ali J, Hamouda AK., Sci Rep. January 19, 2018; 8 (1): 1249.                      

An Intracellular Ammonium Transporter Is Necessary for Replication, Differentiation, and Resistance to Starvation and Osmotic Stress in Trypanosoma cruzi., Cruz-Bustos T, Potapenko E, Storey M, Docampo R., mSphere. January 17, 2018; 3 (1):                   

Functional properties and mechanism of action of PPTQ, an allosteric agonist and low nanomolar positive allosteric modulator at GABA A receptors., Madjroh N, Olander ER, Bundgaard C, Söderhielm PC, Jensen AA., Biochem Pharmacol. January 1, 2018; 147 153-169.

CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing., Moreno-Mateos MA, Fernandez JP, Rouet R, Vejnar CE, Lane MA, Mis E, Khokha MK, Doudna JA, Giraldez AJ., Nat Commun. December 8, 2017; 8 (1): 2024.        

Targeted Base Editing via RNA-Guided Cytidine Deaminases in Xenopus laevis Embryos., Park DS, Yoon M, Kweon J, Jang AH, Kim Y, Choi SC., Mol Cells. November 30, 2017; 40 (11): 823-827.    

Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives., Sapkota K, Irvine MW, Fang G, Burnell ES, Bannister N, Volianskis A, Culley GR, Dravid SM, Collingridge GL, Jane DE, Monaghan DT., Neuropharmacology. October 1, 2017; 125 64-79.

Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors., Bretin S, Louis C, Seguin L, Wagner S, Thomas JY, Challal S, Rogez N, Albinet K, Iop F, Villain N, Bertrand S, Krazem A, Bérachochéa D, Billiald S, Tordjman C, Cordi A, Bertrand D, Lestage P, Danober L., PLoS One. September 8, 2017; 12 (9): e0184429.                        

An analysis of MyoD-dependent transcription using CRISPR/Cas9 gene targeting in Xenopus tropicalis embryos., McQueen C, Pownall ME., Mech Dev. August 1, 2017; 146 1-9.          

High-efficiency non-mosaic CRISPR-mediated knock-in and indel mutation in F0 Xenopus., Aslan Y, Tadjuidje E, Zorn AM, Cha SW., Development. August 1, 2017; 144 (15): 2852-2858.      

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors., Chopra DA, Sapkota K, Irvine MW, Fang G, Jane DE, Monaghan DT, Dravid SM., Sci Rep. July 31, 2017; 7 (1): 6933.          

Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes., Borghese CM, Herman M, Snell LD, Lawrence KJ, Lee HY, Backos DS, Vanderlinden LA, Harris RA, Roberto M, Hoffman PL, Tabakoff B., Sci Rep. July 24, 2017; 7 (1): 6230.        

Co-accumulation of cis-regulatory and coding mutations during the pseudogenization of the Xenopus laevis homoeologs six6.L and six6.S., Ochi H, Kawaguchi A, Tanouchi M, Suzuki N, Kumada T, Iwata Y, Ogino H., Dev Biol. July 1, 2017; 427 (1): 84-92.                      

Exploring the functions of nonclassical MHC class Ib genes in Xenopus laevis by the CRISPR/Cas9 system., Banach M, Edholm ES, Robert J., Dev Biol. June 15, 2017; 426 (2): 261-269.          

Cloning and in vitro characterization of a Schistosoma japonicum aquaglyceroporin that functions in osmoregulation., Huang Y, Li W, Lu W, Xiong C, Yang Y, Yan H, Liu KC, Cao P., Sci Rep. October 13, 2016; 6 35030.        

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting., Wrobel E, Rothenberg I, Krisp C, Hundt F, Fraenzel B, Eckey K, Linders JT, Gallacher DJ, Towart R, Pott L, Pusch M, Yang T, Roden DM, Kurata HT, Schulze-Bahr E, Strutz-Seebohm N, Wolters D, Seebohm G., Nat Commun. October 12, 2016; 7 12795.                  

Rapid and efficient analysis of gene function using CRISPR-Cas9 in Xenopus tropicalis founders., Shigeta M, Sakane Y, Iida M, Suzuki M, Kashiwagi K, Kashiwagi A, Fujii S, Yamamoto T, Suzuki KT., Genes Cells. July 1, 2016; 21 (7): 755-71.                

Photolabeling a Nicotinic Acetylcholine Receptor (nAChR) with an (α4)3(β2)2 nAChR-Selective Positive Allosteric Modulator., Hamouda AK, Deba F, Wang ZJ, Cohen JB., Mol Pharmacol. May 1, 2016; 89 (5): 575-84.

Nucleosome breathing and remodeling constrain CRISPR-Cas9 function., Isaac RS, Jiang F, Doudna JA, Lim WA, Narlikar GJ, Almeida R., Elife. April 28, 2016; 5           

Hermes (Rbpms) is a Critical Component of RNP Complexes that Sequester Germline RNAs during Oogenesis., Aguero T, Zhou Y, Kloc M, Chang P, Houliston E, King ML., J Dev Biol. March 1, 2016; 4 (1):               

Dissection of N,N-diethyl-N'-phenylpiperazines as α7 nicotinic receptor silent agonists., Quadri M, Papke RL, Horenstein NA., Bioorg Med Chem. January 15, 2016; 24 (2): 286-93.

The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors., Chatzidaki A, D'Oyley JM, Gill-Thind JK, Sheppard TD, Millar NS., Neuropharmacology. October 1, 2015; 97 75-85.                        

Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor., Zhang Q, Du Y, Zhang J, Xu X, Xue F, Guo C, Huang Y, Lukas RJ, Chang Y., PLoS One. September 4, 2015; 10 (9): e0137588.                    

Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 Subunit., Weltzin MM, Schulte MK., J Pharmacol Exp Ther. August 1, 2015; 354 (2): 184-94.

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan., Chang TH, Hsieh FL, Zebisch M, Harlos K, Elegheert J, Jones EY., Elife. July 9, 2015; 4                               

Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B., Tang JS, Xie BX, Bian XL, Xue Y, Wei NN, Zhou JH, Hao YC, Li G, Zhang LR, Wang KW., Acta Pharmacol Sin. July 1, 2015; 36 (7): 800-12.                

The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development., Nogueira JM, Hawrot K, Sharpe C, Noble A, Wood WM, Jorge EC, Goldhamer DJ, Kardon G, Dietrich S., Front Aging Neurosci. May 19, 2015; 7 62.                                            

The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor., Papke RL, Bagdas D, Kulkarni AR, Gould T, AlSharari SD, Thakur GA, Damaj MI., Neuropharmacology. April 1, 2015; 91 34-42.

Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects., Gill-Thind JK, Dhankher P, D'Oyley JM, Sheppard TD, Millar NS., J Biol Chem. February 6, 2015; 290 (6): 3552-62.              

GABAA α5 subunit-containing receptors do not contribute to reversal of inflammatory-induced spinal sensitization as indicated by the unique selectivity profile of the GABAA receptor allosteric modulator NS16085., de Lucas AG, Ahring PK, Larsen JS, Rivera-Arconada I, Lopez-Garcia JA, Mirza NR, Munro G., Biochem Pharmacol. February 1, 2015; 93 (3): 370-9.

Targeted gene disruption in Xenopus laevis using CRISPR/Cas9., Wang F, Shi Z, Cui Y, Guo X, Shi YB, Shi YB, Chen Y, Chen Y., Cell Biosci. January 1, 2015; 5 15.            

Nicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggests a Basis for Habitual Use and Anti-Inflammatory Activity., Papke RL, Horenstein NA, Stokes C., PLoS One. January 1, 2015; 10 (10): e0140907.                  

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