Papers associated with lamb3

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	Propofol Is an Allosteric Agonist with Multiple Binding Sites on Concatemeric Ternary GABAA Receptors., Shin DJ, Germann AL, Johnson AD, Forman SA, Steinbach JH, Akk G., Mol Pharmacol. 93 (2): 178-189.
	Chloride deregulation and GABA depolarization in MTOR related malformations of cortical development., Bakouh N, Castaño-Martín R, Metais A, Dan EL, Balducci E, Chhuon C, Lepicka J, Barcia G, Losito E, Lourdel S, Planelles G, Muresan RC, Moca VV, Kaminska A, Bourgeois M, Chemaly N, Rguez Y, Auvin S, Huberfeld G, Varlet P, Asnafi V, Guerrera IC, Kabashi E, Nabbout R, Ciura S, Blauwblomme T., Brain. February 3, 2025; 148 (2): 549-563.
	Glabridin Hypnosis in Zebrafish Larvae Is Associated With Effects on Multiple Anesthetic Target Receptors., Avancha A, Hoyt H, Bhave K, Medeiros M, Cho D, Brown LE, Fernández González D, Porco JA, Forman SA., Anesth Analg. November 21, 2024;
	Cannabichromene from full-spectrum hemp extract exerts acute anti-seizure effects through allosteric activation of GABAA receptors., Wang Z, Zheng H, Yang H, Song H, Lian J, Peng C, Wang H, Zhang H, Zheng Y, Wang Q, Lan L, Duan G, Ma L, Peng X, Huang Z., Fundam Res. November 20, 2024; 4 (6): 1357-1364.
	Direct measurements of neurosteroid binding to specific sites on GABAA receptors., Chintala SM, Tateiwa H, Qian M, Xu Y, Amtashar F, Chen ZW, Kirkpatrick CC, Bracamontes J, Germann AL, Akk G, Covey DF, Evers AS., Br J Pharmacol. November 8, 2024; 181 (21): 4229-4244.
	Inhibitory actions of potentiating neuroactive steroids in the human α1β3γ2L GABAA receptor., Pierce SR, Germann AL, Covey DF, Evers AS, Steinbach JH, Akk G., Mol Pharmacol. October 17, 2024; 106 (5): 264-277.
	3,8-Disubstituted Pyrazolo[1,5-a]quinazoline as GABAA Receptor Modulators: Synthesis, Electrophysiological Assays, and Molecular Modelling Studies., Crocetti L, Guerrini G, Melani F, Mascia MP, Giovannoni MP., Int J Mol Sci. October 9, 2024; 25 (19):
	Postsynaptic receptors regulate presynaptic transmitter stability through transsynaptic bridges., Godavarthi SK, Hiramoto M, Ignatyev Y, Levin JB, Li HQ, Pratelli M, Borchardt J, Czajkowski C, Borodinsky LN, Sweeney L, Cline HT, Spitzer NC., Proc Natl Acad Sci U S A. April 9, 2024; 121 (15): e2318041121.
	Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of α6-Nicotinic Receptors and Dopamine Transporters., Williams BM, Steed ND, Woolley JT, Moedl AA, Nelson CA, Jones GC, Burris MD, Arias HR, Kim OH, Jang EY, Hone AJ, McIntosh JM, Yorgason JT, Steffensen SC., ACS Chem Neurosci. April 1, 2024; 15 (9): 1738-1754.
	Advancements in the use of xenopus oocytes for modelling neurological disease for novel drug discovery., O'Connor EC, Kambara K, Bertrand D., Expert Opin Drug Discov. February 1, 2024; 19 (2): 173-187.
	Substituted Cysteine Modification and Protection with n-Alkyl-MTS Reagents Quantifies Steric Changes Induced by a Mutation in Anesthetic Binding Sites on GABA Type A Receptors., Bhave K, Forman SA., Mol Pharmacol. December 16, 2023; 104 (6): 266-274.
	A neolignan from Connarus tuberosus as an allosteric GABAA receptor modulator at the neurosteroid binding site., Faleschini T, Syafni N, Schulte HL, Garifulina A, Hering S, Espindola LS, Hamburger M., Biomed Pharmacother. May 1, 2023; 161 114498.
	GABAergic Neurotransmission in Human Tissues Is Modulated by Cannabidiol., Ruffolo G, Gaeta A, Cannata B, Pinzaglia C, Aronica E, Morano A, Cifelli P, Palma E., Life (Basel). December 6, 2022; 12 (12):
	GABAA Receptor Modulators with a Pyrazolo[1,5-a]quinazoline Core: Synthesis, Molecular Modelling Studies and Electrophysiological Assays., Crocetti L, Guerrini G, Melani F, Vergelli C, Mascia MP, Giovannoni MP., Int J Mol Sci. October 27, 2022; 23 (21):
	GABAA receptor function is enhanced by Interleukin-10 in human epileptogenic gangliogliomas and its effect is counteracted by Interleukin-1β., Ruffolo G, Alfano V, Romagnolo A, Zimmer T, Mills JD, Cifelli P, Gaeta A, Morano A, Anink J, Mühlebner A, Vezzani A, Aronica E, Palma E., Sci Rep. October 26, 2022; 12 (1): 17956.
	Picrotoxin Delineates Different Transport Configurations for Malate and γ Aminobutyric Acid through TaALMT1., Ramesh SA, Long Y, Dashtbani-Roozbehani A, Gilliham M, Brown MH, Tyerman SD., Biology (Basel). August 2, 2022; 11 (8):
	Tricyclic antipsychotics and antidepressants can inhibit α5-containing GABAA receptors by two distinct mechanisms., Bampali K, Koniuszewski F, Silva LL, Rehman S, Vogel FD, Seidel T, Scholze P, Zirpel F, Garon A, Langer T, Willeit M, Ernst M., Br J Pharmacol. July 1, 2022; 179 (14): 3675-3692.
	Unexpected Effect of IL-1β on the Function of GABAA Receptors in Pediatric Focal Cortical Dysplasia., Alfano V, Romagnolo A, Mills JD, Cifelli P, Gaeta A, Morano A, Mühlebner A, Aronica E, Palma E, Ruffolo G., Brain Sci. June 19, 2022; 12 (6):
	Clerodane Diterpenes from Casearia corymbosa as Allosteric GABAA Receptor Modulators., Syafni N, Faleschini MT, Garifulina A, Danton O, Gupta MP, Hering S, Hamburger M., J Nat Prod. May 27, 2022; 85 (5): 1201-1210.
	Sea anemone Bartholomea annulata venom inhibits voltage-gated Na+ channels and activates GABAA receptors from mammals., Colom-Casasnovas A, Garay E, Cisneros-Mejorado A, Aguilar MB, Lazcano-Pérez F, Arellano RO, Sánchez-Rodríguez J., Sci Rep. March 30, 2022; 12 (1): 5352.
	Anesthetic Pharmacology of the Mint Extracts L-Carvone and Methyl Salicylate., Brosnan RJ, Ramos K, Aguiar AJA, Cenani A, Knych HK., Pharmacology. January 1, 2022; 107 (3-4): 167-178.
	Discovery and functional characterization of N-(thiazol-2-yl)-benzamide analogs as the first class of selective antagonists of the Zinc-Activated Channel (ZAC)., Madjroh N, Mellou E, Davies PA, Söderhielm PC, Jensen AA., Biochem Pharmacol. November 1, 2021; 193 114782.
	Stigmasterol can be new steroidal drug for neurological disorders: Evidence of the GABAergic mechanism via receptor modulation., Karim N, Khan I, Abdelhalim A, Halim SA, Khan A, Al-Harrasi A., Phytomedicine. September 1, 2021; 90 153646.
	Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site., Sridhar A, Lummis SCR, Pasini D, Mehregan A, Brams M, Kambara K, Bertrand D, Lindahl E, Howard RJ, Ulens C., J Biol Chem. August 1, 2021; 297 (2): 100899.
	Substituted Cysteine Modification and Protection with n-Alkyl- Methanethiosulfonate Reagents Yields a Precise Estimate of the Distance between Etomidate and a Residue in Activated GABA Type A Receptors., Fantasia RJ, Nourmahnad A, Halpin E, Forman SA., Mol Pharmacol. June 25, 2021; 99 (6): 426-434.
	Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man., Hipp JF, Knoflach F, Comley R, Ballard TM, Honer M, Trube G, Gasser R, Prinssen E, Wallace TL, Rothfuss A, Knust H, Lennon-Chrimes S, Derks M, Bentley D, Squassante L, Nave S, Nöldeke J, Wandel C, Thomas AW, Hernandez MC., Sci Rep. April 8, 2021; 11 (1): 7700.
	Efficient expression of concatenated α1β2δ and α1β3δ GABAA receptors, their pharmacology and stoichiometry., Liao VWY, Chebib M, Ahring PK., Br J Pharmacol. April 1, 2021; 178 (7): 1556-1573.
	Dissecting the Molecular Determinants of GABAA Receptors Current Rundown, a Hallmark of Refractory Human Epilepsy., Cifelli P, Di Angelantonio S, Alfano V, Morano A, De Felice E, Aronica E, Ruffolo G, Palma E., Brain Sci. March 30, 2021; 11 (4):
	Targeting GABAC Receptors Improves Post-Stroke Motor Recovery., van Nieuwenhuijzen PS, Parker K, Liao V, Houlton J, Kim HL, Johnston GAR, Hanrahan JR, Chebib M, Clarkson AN., Brain Sci. March 2, 2021; 11 (3):
	Characterization of the GABRB2-Associated Neurodevelopmental Disorders., El Achkar CM, Harrer M, Smith L, Kelly M, Iqbal S, Maljevic S, Niturad CE, Vissers LELM, Poduri A, Yang E, Lal D, Lerche H, Møller RS, Olson HE, GABRB2 Working Group., Ann Neurol. March 1, 2021; 89 (3): 573-586.
	Modulation of α1β3γ2 GABAA receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix., Borghese CM, Wang HL, McHardy SF, Messing RO, Trudell JR, Harris RA, Bertaccini EJ., Proc Natl Acad Sci U S A. February 23, 2021; 118 (8):
	Novel Three-Finger Neurotoxins from Naja melanoleuca Cobra Venom Interact with GABAA and Nicotinic Acetylcholine Receptors., Son L, Kryukova E, Ziganshin R, Andreeva T, Kudryavtsev D, Kasheverov I, Tsetlin V, Utkin Y., Toxins (Basel). February 20, 2021; 13 (2):
	A critical residue in the α1M2-M3 linker regulating mammalian GABAA receptor pore gating by diazepam., Nors JW, Gupta S, Goldschen-Ohm MP., Elife. February 16, 2021; 10
	'Proximity frequencies' a new parameter to evaluate the profile of GABAAR modulators., Crocetti L, Guerrini G, Cantini N, Vergelli C, Melani F, Mascia MP, Giovannoni MP., Bioorg Med Chem Lett. February 15, 2021; 34 127755.
	The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the α1β3γ2L GABAA Receptor by Stabilizing a Novel Nonconducting State., Pierce SR, Germann AL, Steinbach JH, Akk G., Mol Pharmacol. February 1, 2021; 101 (2): 68-77.
	The anticonvulsant zonisamide positively modulates recombinant and native glycine receptors at clinically relevant concentrations., Devenish SO, Winters BL, Anderson LL, Arnold JC, McGregor IS, Vaughan CW, Chebib M, Absalom NL., Neuropharmacology. January 1, 2021; 182 108371.
	Reduced Activation of the Synaptic-Type GABAA Receptor Following Prolonged Exposure to Low Concentrations of Agonists: Relationship between Tonic Activity and Desensitization., Pierce SR, Germann AL, Evers AS, Steinbach JH, Akk G., Mol Pharmacol. December 25, 2020; 98 (6): 762-769.
	In vitro and in vivo characterization of Lu AA41178: A novel, brain penetrant, pan-selective Kv7 potassium channel opener with efficacy in preclinical models of epileptic seizures and psychiatric disorders., Grupe M, Bentzen BH, Benned-Jensen T, Nielsen V, Frederiksen K, Jensen HS, Jacobsen AM, Skibsbye L, Sams AG, Grunnet M, Rottländer M, Bastlund JF., Eur J Pharmacol. November 15, 2020; 887 173440.
	PNU-120596, a positive allosteric modulator of mammalian α7 nicotinic acetylcholine receptor, is a negative modulator of ligand-gated chloride-selective channels of the gastropod Lymnaea stagnalis., Vulfius CA, Lebedev DS, Kryukova EV, Kudryavtsev DS, Kolbaev SN, Utkin YN, Tsetlin VI., J Neurochem. November 1, 2020; 155 (3): 274-284.
	Apremilast regulates acute effects of ethanol and other GABAergic drugs via protein kinase A-dependent signaling., Blednov YA, Borghese CM, Dugan MP, Pradhan S, Thodati TM, Kichili NR, Harris RA, Messing RO., Neuropharmacology. November 1, 2020; 178 108220.
	The desensitization pathway of GABAA receptors, one subunit at a time., Gielen M, Barilone N, Corringer PJ., Nat Commun. October 23, 2020; 11 (1): 5369.
	Analysis of Modulation of the ρ1 GABAA Receptor by Combinations of Inhibitory and Potentiating Neurosteroids Reveals Shared and Distinct Binding Sites., Germann AL, Reichert DE, Burbridge AB, Pierce SR, Evers AS, Steinbach JH, Akk G., Mol Pharmacol. October 16, 2020; 98 (4): 280-291.
	Site-specific effects of neurosteroids on GABAA receptor activation and desensitization., Sugasawa Y, Cheng WW, Bracamontes JR, Chen ZW, Wang L, Germann AL, Pierce SR, Senneff TC, Krishnan K, Reichert DE, Covey DF, Akk G, Evers AS., Elife. September 21, 2020; 9
	Erythropoietin Increases GABAA Currents in Human Cortex from TLE Patients., Roseti C, Cifelli P, Ruffolo G, Barbieri E, Guescini M, Esposito V, Di Gennaro G, Limatola C, Giovannelli A, Aronica E, Palma E., Neuroscience. July 15, 2020; 439 153-162.
	Rare Diseases of Neurodevelopment: Maintain the Mystery or Use a Dazzling Tool for Investigation? The Case of Rett Syndrome., Ruffolo G, Cifelli P, Miranda-Lourenço C, De Felice E, Limatola C, Sebastião AM, Diógenes MJ, Aronica E, Palma E., Neuroscience. July 15, 2020; 439 146-152.
	Differential Coassembly of α1-GABAARs Associated with Epileptic Encephalopathy., Hannan S, Affandi AHB, Minere M, Jones C, Goh P, Warnes G, Popp B, Trollmann R, Nizetic D, Smart TG., J Neurosci. July 15, 2020; 40 (29): 5518-5530.
	Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions., Ihara M, Furutani S, Shigetou S, Shimada S, Niki K, Komori Y, Kamiya M, Koizumi W, Magara L, Hikida M, Noguchi A, Okuhara D, Yoshinari Y, Kondo S, Tanimoto H, Niwa R, Sattelle DB, Matsuda K., Proc Natl Acad Sci U S A. July 14, 2020; 117 (28): 16283-16291.
	A potent photoreactive general anesthetic with novel binding site selectivity for GABAA receptors., Shalabi AR, Yu Z, Zhou X, Jounaidi Y, Chen H, Dai J, Kent DE, Feng HJ, Forman SA, Cohen JB, Bruzik KS, Miller KW., Eur J Med Chem. May 15, 2020; 194 112261.
	Functional characterization of the antiepileptic drug candidate, padsevonil, on GABAA receptors., Niespodziany I, Ghisdal P, Mullier B, Wood M, Provins L, Kaminski RM, Wolff C., Epilepsia. May 1, 2020; 61 (5): 914-923.
	Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons., Joshi S, Roden WH, Kapur J, Jansen LA., Ann Clin Transl Neurol. April 3, 2020; 7 (4): 527-542.

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