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Summary Expression Phenotypes Gene Literature (300) GO Terms (10) Nucleotides (63) Proteins (7) Interactants (185) Wiki
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Papers associated with magainins



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Detection of pathogenic gram-negative bacteria using an antimicrobial peptides-modified bipolar electrode-electrochemiluminescence platform., Ji L, Wang F, Qi Y, Qiao F, Xiong X, Liu Y., Mikrochim Acta. October 5, 2024; 191 (11): 648.

Amphibian mast cells serve as barriers to chytrid fungus infections., Hauser KA, Garvey CN, Crow RS, Hossainey MRH, Howard DT, Ranganathan N, Gentry LK, Yaparla A, Kalia N, Zelle M, Jones EJ, Duttargi AN, Rollins-Smith LA, Muletz-Wolz CR, Grayfer L., Elife. July 31, 2024; 12   


Peptide Flexibility and the Hydrophobic Moment are Determinants to Evaluate the Clinical Potential of Magainins., Balleza D., J Membr Biol. December 1, 2023; 256 (4-6): 317-330.

Amphibian-Derived Natural Anticancer Peptides and Proteins: Mechanism of Action, Application Strategies, and Prospects., Chen Q, Wu J, Li X, Ye Z, Yang H, Mu L., Int J Mol Sci. September 12, 2023; 24 (18):   


The effects of magainin 2-derived and rationally designed antimicrobial peptides on Mycoplasma pneumoniae., Hayashi K, Misawa T, Goto C, Demizu Y, Hara-Kudo Y, Kikuchi Y., PLoS One. January 24, 2022; 17 (1): e0261893.   


Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence., Hirano M, Saito C, Yokoo H, Goto C, Kawano R, Misawa T, Demizu Y., Molecules. January 16, 2021; 26 (2):   


Review: Examining the Natural Role of Amphibian Antimicrobial Peptide Magainin., McMillan KAM, Coombs MRP., Molecules. November 20, 2020; 25 (22):   


Highly synergistic antimicrobial activity of magainin 2 and PGLa peptides is rooted in the formation of supramolecular complexes with lipids., Aisenbrey C, Amaro M, Pospíšil P, Hof M, Bechinger B., Sci Rep. July 15, 2020; 10 (1): 11652.

Development of Amphipathic Antimicrobial Peptide Foldamers Based on Magainin 2 Sequence., Goto C, Hirano M, Hayashi K, Kikuchi Y, Hara-Kudo Y, Misawa T, Demizu Y., ChemMedChem. November 20, 2019; 14 (22): 1911-1916.

Grafted Polymer Coatings Enhance Fouling Inhibition by an Antimicrobial Peptide on Reverse Osmosis Membranes., Shtreimer Kandiyote N, Avisdris T, Arnusch CJ, Kasher R., Langmuir. February 5, 2019; 35 (5): 1935-1943.

Antibacterial and Antibiofilm Activity and Mode of Action of Magainin 2 against Drug-Resistant Acinetobacter baumannii., Kim MK, Kang N, Ko SJ, Park J, Park E, Shin DW, Kim SH, Lee SA, Lee JI, Lee SH, Ha EG, Jeon SH, Park Y., Int J Mol Sci. October 5, 2018; 19 (10):   


Effects of Amphipathic Polypeptides on Membrane Organization Inferred from Studies Using Bicellar Lipid Mixtures., Miranda C, Booth VK, Morrow MR., Langmuir. October 2, 2018; 34 (39): 11759-11771.

Efficacy of designer K11 antimicrobial peptide (a hybrid of melittin, cecropin A1 and magainin 2) against Acinetobacter baumannii-infected wounds., Rishi P, Vashist T, Sharma A, Kaur A, Kaur A, Kaur N, Kaur IP, Tewari R., Pathog Dis. October 1, 2018; 76 (7):


Synergy on Surfaces: Anti-Biofouling Interfaces Using Surface-Attached Antimicrobial Peptides PGLa and Magainin-2., Shtreimer Kandiyote N, Mohanraj G, Mao C, Kasher R, Arnusch CJ., Langmuir. September 18, 2018; 34 (37): 11147-11155.

Frog Skin Innate Immune Defences: Sensing and Surviving Pathogens., Varga JFA, Bui-Marinos MP, Katzenback BA., Front Immunol. September 12, 2018; 9 3128.   

Mechanism of Initial Stage of Pore Formation Induced by Antimicrobial Peptide Magainin 2., Hasan M, Karal MAS, Levadnyy V, Yamazaki M., Langmuir. March 13, 2018; 34 (10): 3349-3362.

Peptidomic analysis of skin secretions of the Mexican burrowing toad Rhinophrynus dorsalis (Rhinophrynidae): Insight into the origin of host-defense peptides within the Pipidae and characterization of a proline-arginine-rich peptide., Conlon JM, Guilhaudis L, Leprince J, Coquet L, Mangoni ML, Attoub S, Jouenne T, King JD., Peptides. November 1, 2017; 97 22-28.

2H-NMR and MD Simulations Reveal Membrane-Bound Conformation of Magainin 2 and Its Synergy with PGLa., Strandberg E, Horn D, Reißer S, Zerweck J, Wadhwani P, Ulrich AS., Biophys J. November 15, 2016; 111 (10): 2149-2161.

Peptidomic analysis of the extensive array of host-defense peptides in skin secretions of the dodecaploid frog Xenopus ruwenzoriensis (Pipidae)., Coquet L, Kolodziejek J, Jouenne T, Nowotny N, King JD, Conlon JM., Comp Biochem Physiol Part D Genomics Proteomics. September 1, 2016; 19 18-24.

Physicochemical and biological characterizations of Pxt peptides from amphibian (Xenopus tropicalis) skin., Shigeri Y, Horie M, Yoshida T, Hagihara Y, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M., J Biochem. June 1, 2016; 159 (6): 619-29.

Investigations of the synergistic enhancement of antimicrobial activity in mixtures of magainin 2 and PGLa., Glattard E, Salnikov ES, Aisenbrey C, Bechinger B., Biophys Chem. March 1, 2016; 210 35-44.

Channel Current Analysis for Pore-forming Properties of an Antimicrobial Peptide, Magainin 1, Using the Droplet Contact Method., Watanabe H, Kawano R., Anal Sci. January 1, 2016; 32 (1): 57-60.

Antimicrobial Peptide CMA3 Derived from the CA-MA Hybrid Peptide: Antibacterial and Anti-inflammatory Activities with Low Cytotoxicity and Mechanism of Action in Escherichia coli., Lee JK, Seo CH, Luchian T, Park Y., Antimicrob Agents Chemother. November 9, 2015; 60 (1): 495-506.

Host-defense and trefoil factor family peptides in skin secretions of the Mawa clawed frog Xenopus boumbaensis (Pipidae)., Conlon JM, Mechkarska M, Kolodziejek J, Leprince J, Coquet L, Jouenne T, Vaudry H, Nowotny N, King JD., Peptides. October 1, 2015; 72 44-9.

Peptoid-Substituted Hybrid Antimicrobial Peptide Derived from Papiliocin and Magainin 2 with Enhanced Bacterial Selectivity and Anti-inflammatory Activity., Shin A, Lee E, Jeon D, Park YG, Bang JK, Park YS, Shin SY, Kim Y., Biochemistry. June 30, 2015; 54 (25): 3921-31.

Influence of hydrophobic residues on the activity of the antimicrobial peptide magainin 2 and its synergy with PGLa., Strandberg E, Zerweck J, Horn D, Pritz G, Berditsch M, Bürck J, Wadhwani P, Ulrich AS., J Pept Sci. May 1, 2015; 21 (5): 436-45.

Evidence from peptidomic analysis of skin secretions that allopatric populations of Xenopus gilli (Anura:Pipidae) constitute distinct lineages., Conlon JM, Mechkarska M, Coquet L, Leprince J, Jouenne T, Vaudry H, Measey GJ., Peptides. January 1, 2015; 63 118-25.

Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice., Ojo OO, Srinivasan DK, Owolabi BO, Conlon JM, Flatt PR, Abdel-Wahab YH., Biochim Biophys Acta. January 1, 2015; 1850 (1): 80-7.

Magainin II modified polydiacetylene micelles for cancer therapy., Yang D, Zou R, Zhu Y, Liu B, Yao D, Jiang J, Wu J, Tian H., Nanoscale. December 21, 2014; 6 (24): 14772-83.

Magainin 2 induces bacterial cell death showing apoptotic properties., Lee W, Lee DG., Curr Microbiol. December 1, 2014; 69 (6): 794-801.

Host-defense peptides from skin secretions of Fraser's clawed frog Xenopus fraseri (Pipidae): Further insight into the evolutionary history of the Xenopodinae., Conlon JM, Mechkarska M, Kolodziejek J, Nowotny N, Coquet L, Leprince J, Jouenne T, Vaudry H., Comp Biochem Physiol Part D Genomics Proteomics. December 1, 2014; 12 45-52.

Local pressure changes in lipid bilayers due to adsorption of melittin and magainin-h2 antimicrobial peptides: results from computer simulations., Goliaei A, Santo KP, Berkowitz ML., J Phys Chem B. November 6, 2014; 118 (44): 12673-9.

Antimicrobial and immunomodulatory properties of PGLa-AM1, CPF-AM1, and magainin-AM1: Potent activity against oral pathogens., McLean DT, McCrudden MT, Linden GJ, Irwin CR, Conlon JM, Lundy FT., Regul Pept. November 1, 2014; .

Investigating specific bacterial resistance to AMPs by using a magainin I-resistant Escherichia coli model., de Almeida KC, Lima TB, Motta DO, Silva ON, Magalhães BS, Dias SC, Franco OL., J Antibiot (Tokyo). October 1, 2014; 67 (10): 681-7.

Host-defense peptides from skin secretions of the octoploid frogs Xenopus vestitus and Xenopus wittei (Pipidae): insights into evolutionary relationships., Mechkarska M, Coquet L, Leprince J, Jouenne T, Vaudry H, Michalak K, Michalak P, Conlon JM., Comp Biochem Physiol Part D Genomics Proteomics. September 1, 2014; 11 20-8.

[Optimization of coding sequences and expression of antimicrobial peptide magainin II in Escherichia coli and Pichia pastoris]., Chen Y, Chen Q, Chen K, Zhang T, Chen J., Sheng Wu Gong Cheng Xue Bao. April 1, 2014; 30 (4): 615-24.

Circular Dichroism studies on the interactions of antimicrobial peptides with bacterial cells., Avitabile C, D'Andrea LD, Romanelli A., Sci Rep. March 12, 2014; 4 4293.   


Host-defense peptides with therapeutic potential from skin secretions of frogs from the family pipidae., Conlon JM, Mechkarska M., Pharmaceuticals (Basel). January 15, 2014; 7 (1): 58-77.   


Magainin-related peptides stimulate insulin-release and improve glucose tolerance in high fat fed mice., Ojo OO, Srinivasan DK, Owolabi BO, Flatt PR, Abdel-Wahab YH., Protein Pept Lett. January 1, 2014; 22 (3): 256-63.

Effects of cationic antimicrobial peptides on liquid-preserved boar spermatozoa., Schulze M, Junkes C, Mueller P, Speck S, Ruediger K, Dathe M, Mueller K., PLoS One. January 1, 2014; 9 (6): e100490.   


Evidence for phenylalanine zipper-mediated dimerization in the X-ray crystal structure of a magainin 2 analogue., Hayouka Z, Mortenson DE, Kreitler DF, Weisblum B, Forest KT, Gellman SH., J Am Chem Soc. October 23, 2013; 135 (42): 15738-15741.

Peptidomic analysis of skin secretions provides insight into the taxonomic status of the African clawed frogs Xenopus victorianus and Xenopus laevis sudanensis (Pipidae)., King JD, Mechkarska M, Meetani MA, Conlon JM., Comp Biochem Physiol Part D Genomics Proteomics. September 1, 2013; 8 (3): 250-4.

A comparison of host-defense peptides in skin secretions of female Xenopus laevis × Xenopus borealis and X. borealis × X. laevis F1 hybrids., Mechkarska M, Prajeep M, Leprince J, Vaudry H, Meetani MA, Evans BJ, Conlon JM., Peptides. July 1, 2013; 45 1-8.

Antimicrobial potential of lycosin-I, a cationic and amphiphilic peptide from the venom of the spider Lycosa singorensis., Tan H, Ding X, Meng S, Liu C, Wang H, Xia L, Liu Z, Liang S., Curr Mol Med. July 1, 2013; 13 (6): 900-10.

Penetratin-mediated delivery enhances the antitumor activity of the cationic antimicrobial peptide Magainin II., Liu S, Yang H, Wan L, Cheng J, Lu X., Cancer Biother Radiopharm. May 1, 2013; 28 (4): 289-97.

Synergistic insertion of antimicrobial magainin-family peptides in membranes depends on the lipid spontaneous curvature., Strandberg E, Zerweck J, Wadhwani P, Ulrich AS., Biophys J. March 19, 2013; 104 (6): L9-11.

Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents., Srinivasan D, Mechkarska M, Abdel-Wahab YH, Flatt PR, Conlon JM., Biochimie. February 1, 2013; 95 (2): 429-35.

Frog skin peptides (tigerinin-1R, magainin-AM1, -AM2, CPF-AM1, and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTag cells., Ojo OO, Conlon JM, Flatt PR, Abdel-Wahab YH., Biochem Biophys Res Commun. February 1, 2013; 431 (1): 14-8.   


Recombinant expression and purification of the antimicrobial peptide magainin-2., Ramos R, Moreira S, Rodrigues A, Gama M, Domingues L., Biotechnol Prog. January 1, 2013; 29 (1): 17-22.

Hybridization between the African clawed frogs Xenopus laevis and Xenopus muelleri (Pipidae) increases the multiplicity of antimicrobial peptides in skin secretions of female offspring., Mechkarska M, Meetani M, Michalak P, Vaksman Z, Takada K, Conlon JM., Comp Biochem Physiol Part D Genomics Proteomics. September 1, 2012; 7 (3): 285-91.

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