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Summary Expression Phenotypes Gene Literature (53) GO Terms (0) Nucleotides (117) Proteins (49) Interactants (185) Wiki

Papers associated with ecd

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2 paper(s) referencing morpholinos

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Expression of Mutant Glycine Receptors in Xenopus Oocytes Using Canonical and Non-Canonical Amino Acids Reveals Distinct Roles of Conserved Proline Residues., Lummis SCR, Dougherty DA., Membranes (Basel). October 19, 2022; 12 (10):

Clerodane Diterpenes from Casearia corymbosa as Allosteric GABAA Receptor Modulators., Syafni N, Faleschini MT, Garifulina A, Danton O, Gupta MP, Hering S, Hamburger M., J Nat Prod. May 27, 2022; 85 (5): 1201-1210.

Probing the molecular basis for signal transduction through the Zinc-Activated Channel (ZAC)., Madjroh N, Mellou E, Æbelø L, Davies PA, Söderhielm PC, Jensen AA., Biochem Pharmacol. November 1, 2021; 193 114781.

Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel., Bergh C, Heusser SA, Howard R, Lindahl E., Elife. October 15, 2021; 10                                             

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation., Lefebvre SN, Taly A, Menny A, Medjebeur K, Corringer PJ., Elife. September 30, 2021; 10                               

Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain., Kulbatskii D, Shenkarev Z, Bychkov M, Loktyushov E, Shulepko M, Koshelev S, Povarov I, Popov A, Peigneur S, Chugunov A, Kozlov S, Sharonova I, Efremov R, Skrebitsky V, Tytgat J, Kirpichnikov M, Lyukmanova E., Front Cell Dev Biol. January 1, 2021; 9 662227.                  

The desensitization pathway of GABAA receptors, one subunit at a time., Gielen M, Barilone N, Corringer PJ., Nat Commun. October 23, 2020; 11 (1): 5369.                

Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs., Bernhard M, Laube B., Sci Rep. October 6, 2020; 10 (1): 16569.          

Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs., Kumar A, Basak S, Rao S, Gicheru Y, Mayer ML, Sansom MSP, Chakrapani S., Nat Commun. July 27, 2020; 11 (1): 3752.            

Gating control of the cardiac sodium channel Nav1.5 by its β3-subunit involves distinct roles for a transmembrane glutamic acid and the extracellular domain., Salvage SC, Zhu W, Habib ZF, Hwang SS, Irons JR, Huang CLH, Silva JR, Jackson AP., J Biol Chem. December 20, 2019; 294 (51): 19752-19763.            

Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor., Basak S, Gicheru Y, Kapoor A, Mayer ML, Filizola M, Chakrapani S., Nat Commun. July 19, 2019; 10 (1): 3225.                                    

A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels., Wu Y, Chen Z, Canessa CM., Elife. May 2, 2019; 8               

Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models., Kryukova EV, Ivanov IA, Lebedev DS, Spirova EN, Egorova NS, Zouridakis M, Kasheverov IE, Tzartos SJ, Tsetlin VI., Mar Drugs. November 22, 2018; 16 (12):             

Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor., Basak S, Gicheru Y, Rao S, Sansom MSP, Chakrapani S., Nature. November 1, 2018; 563 (7730): 270-274.

Structural basis of neurosteroid anesthetic action on GABAA receptors., Chen Q, Wells MM, Arjunan P, Tillman TS, Cohen AE, Xu Y, Xu Y, Tang P., Nat Commun. September 28, 2018; 9 (1): 3972.              

Multiple regions in the extracellular domain of the glycine receptor determine receptor activity., Tang B, Lummis SCR., J Biol Chem. September 7, 2018; 293 (36): 13889-13896.                    

Identification of Novel Functionally Important Aromatic Residue Interactions in the Extracellular Domain of the Glycine Receptor., Tang B, Devenish SO, Lummis SCR., Biochemistry. July 10, 2018; 57 (27): 4029-4035.

Cryo-EM structure of 5-HT3A receptor in its resting conformation., Basak S, Gicheru Y, Samanta A, Molugu SK, Huang W, Fuente M, Hughes T, Taylor DJ, Nieman MT, Moiseenkova-Bell V, Chakrapani S., Nat Commun. February 6, 2018; 9 (1): 514.          

EphA7 regulates claudin6 and pronephros development in Xenopus., Sun J, Wang X, Shi Y, Shi Y, Li J, Li C, Shi Z, Chen Y, Chen Y, Mao B., Biochem Biophys Res Commun. January 8, 2018; 495 (2): 1580-1587.        

Menthol Stereoisomers Exhibit Different Effects on α4β2 nAChR Upregulation and Dopamine Neuron Spontaneous Firing., Henderson BJ, Grant S, Chu BW, Shahoei R, Huard SM, Saladi SSM, Tajkhorshid E, Dougherty DA, Lester HA., eNeuro. January 1, 2018; 5 (6):                   

A chimeric prokaryotic-eukaryotic pentameric ligand gated ion channel reveals interactions between the extracellular and transmembrane domains shape neurosteroid modulation., Ghosh B, Tsao TW, Czajkowski C., Neuropharmacology. October 1, 2017; 125 343-352.

Digital dissection of the model organism Xenopus laevis using contrast-enhanced computed tomography., Porro LB, Richards CT., J Anat. August 1, 2017; 231 (2): 169-191.                        

The Proton Responsiveness in the Extracellular Domain of GLIC Differs in the Presence of the ELIC Transmembrane Domain., Alqazzaz MA, Price KL, Lummis SCR., Biochemistry. April 18, 2017; 56 (15): 2134-2138.

Identification of a pre-active conformation of a pentameric channel receptor., Menny A, Lefebvre SN, Schmidpeter PA, Drège E, Fourati Z, Delarue M, Edelstein SJ, Nimigean CM, Joseph D, Corringer PJ., Elife. March 15, 2017; 6                             

Functional characterization of two prokaryotic pentameric ligand-gated ion channel chimeras - role of the GLIC transmembrane domain in proton sensing., Hénault CM, Baenziger JE., Biochim Biophys Acta Biomembr. February 1, 2017; 1859 (2): 218-227.

Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors., Vulfius CA, Kasheverov IE, Kryukova EV, Spirova EN, Shelukhina IV, Starkov VG, Andreeva TV, Faure G, Zouridakis M, Tsetlin VI, Utkin YN., PLoS One. January 1, 2017; 12 (10): e0186206.            

Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors., Levitz J, Habrian C, Bharill S, Fu Z, Vafabakhsh R, Isacoff EY., Neuron. October 5, 2016; 92 (1): 143-159.                                  

Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound α2 homopentamer., Kouvatsos N, Giastas P, Chroni-Tzartou D, Poulopoulou C, Tzartos SJ., Proc Natl Acad Sci U S A. August 23, 2016; 113 (34): 9635-40.

Secreted Frizzled-related Protein 2 (sFRP2) Redirects Non-canonical Wnt Signaling from Fz7 to Ror2 during Vertebrate Gastrulation., Brinkmann EM, Mattes B, Kumar R, Hagemann AI, Gradl D, Scholpp S, Steinbeisser H, Kaufmann LT, Özbek S., J Biol Chem. June 24, 2016; 291 (26): 13730-42.              

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus)., Ostrowski M, Porowinska D, Prochnicki T, Prevost M, Raynal B, Baron B, Sauguet L, Corringer PJ, Faure G., Toxicon. June 15, 2016; 116 63-71.

The Ascaris suum nicotinic receptor, ACR-16, as a drug target: Four novel negative allosteric modulators from virtual screening., Zheng F, Robertson AP, Abongwa M, Yu EW, Martin RJ., Int J Parasitol Drugs Drug Resist. February 10, 2016; 6 (1): 60-73.            

A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation., Schmandt N, Velisetty P, Chalamalasetti SV, Stein RA, Bonner R, Talley L, Parker MD, Mchaourab HS, Yee VC, Lodowski DT, Chakrapani S., J Gen Physiol. October 1, 2015; 146 (4): 323-40.              

The NOTCH signaling pathway in normal and malignant blood cell production., Suresh S, Irvine AE., J Cell Commun Signal. March 1, 2015; 9 (1): 5-13.      

Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain., Zouridakis M, Giastas P, Zarkadas E, Chroni-Tzartou D, Bregestovski P, Tzartos SJ., Nat Struct Mol Biol. November 1, 2014; 21 (11): 976-80.

The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission., Assmann M, Kuhn A, Dürrnagel S, Holstein TW, Gründer S., BMC Biol. October 14, 2014; 12 84.                      

Impact of intracellular domain flexibility upon properties of activated human 5-HT3 receptors., Kozuska JL, Paulsen IM, Belfield WJ, Martin IL, Cole DJ, Holt A, Dunn SM., Br J Pharmacol. April 1, 2014; 171 (7): 1617-28.      

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength., de Lau W, Peng WC, Gros P, Clevers H., Genes Dev. February 15, 2014; 28 (4): 305-16.          

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation., Sauguet L, Shahsavar A, Poitevin F, Huon C, Menny A, Nemecz À, Haouz A, Changeux JP, Corringer PJ, Delarue M., Proc Natl Acad Sci U S A. January 21, 2014; 111 (3): 966-71.        

The bile acid-sensitive ion channel (BASIC) is activated by alterations of its membrane environment., Schmidt A, Lenzig P, Oslender-Bujotzek A, Kusch J, Lucas SD, Gründer S, Wiemuth D., PLoS One. January 1, 2014; 9 (10): e111549.                    

Phytochemical profiling of Curcuma kwangsiensis rhizome extract, and identification of labdane diterpenoids as positive GABAA receptor modulators., Schramm A, Ebrahimi SN, Raith M, Zaugg J, Rueda DC, Hering S, Hamburger M., Phytochemistry. December 1, 2013; 96 318-29.

Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni., Dufour V, Beech RN, Wever C, Dent JA, Geary TG., PLoS Pathog. January 1, 2013; 9 (8): e1003586.            

Identification of GABA A receptor modulators in Kadsura longipedunculata and assignment of absolute configurations by quantum-chemical ECD calculations., Zaugg J, Ebrahimi SN, Smiesko M, Baburin I, Hering S, Hamburger M., Phytochemistry. December 1, 2011; 72 (18): 2385-95.

Engineering a prokaryotic Cys-loop receptor with a third functional domain., Goyal R, Salahudeen AA, Jansen M., J Biol Chem. October 7, 2011; 286 (40): 34635-42.

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family., Duret G, Van Renterghem C, Weng Y, Prevost M, Moraga-Cid G, Huon C, Sonner JM, Corringer PJ., Proc Natl Acad Sci U S A. July 19, 2011; 108 (29): 12143-8.

Identification of the roles of conserved charged residues in the extracellular domain of an epithelial sodium channel (ENaC) subunit by alanine mutagenesis., Edelheit O, Hanukoglu I, Dascal N, Hanukoglu A., Am J Physiol Renal Physiol. April 1, 2011; 300 (4): F887-97.

The non-methylated DNA-binding function of Kaiso is not required in early Xenopus laevis development., Ruzov A, Savitskaya E, Hackett JA, Reddington JP, Prokhortchouk A, Madej MJ, Chekanov N, Li M, Dunican DS, Prokhortchouk E, Pennings S, Meehan RR., Development. March 1, 2009; 136 (5): 729-38.            

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin., Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E, Lee E., Proc Natl Acad Sci U S A. June 10, 2008; 105 (23): 8032-7.        

DNA damage-induced replication arrest in Xenopus egg extracts., Stokes MP, Michael WM., J Cell Biol. October 27, 2003; 163 (2): 245-55.                

A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos., Stancheva I, Collins AL, Van den Veyver IB, Zoghbi H, Meehan RR., Mol Cell. August 1, 2003; 12 (2): 425-35.                          

Immunocytochemical study of activin type IB receptor (XALK4) in Xenopus oocytes., Fukui A, Komazaki S, Miyoshi O, Asashima M., Dev Growth Differ. April 1, 2003; 45 (2): 113-9.        

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