Monarch Ortholog Phenotypes
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Mouse (21 sources):
abnormal CNS synaptic transmission,
abnormal brain wave pattern,
abnormal excitatory postsynaptic potential,
abnormal excitatory synapse morphology,
abnormal inhibitory postsynaptic currents,
abnormal inhibitory synapse morphology,
abnormal miniature excitatory postsynaptic currents,
abnormal nest building behavior,
abnormal response to novel object,
abnormal synaptic plasticity,
abnormal synaptic vesicle morphology,
abnormal synaptic vesicle number,
abnormal synaptic vesicle recycling,
decreased anxiety-related response,
decreased excitatory postsynaptic current amplitude,
enhanced paired-pulse facilitation,
lethality at weaning, incomplete penetrance,
limb grasping,
nervous system phenotype,
postnatal lethality, incomplete penetrance,
premature death
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