Monarch Ortholog Phenotypes
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Human (12 sources):
Bronchiectasis,
Cholangitis,
Chronic diarrhea,
Chronic hepatitis due to cryptosporidium infection,
Cirrhosis,
Failure to thrive,
Hepatic failure,
Immunodeficiency,
Pneumonia,
Recurrent infections,
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Mouse (36 sources):
abnormal CD4-positive T cell differentiation,
abnormal CD8-positive, alpha-beta T cell physiology,
abnormal Langerhans cell physiology,
abnormal T cell activation,
abnormal T-helper 1 physiology,
abnormal T-helper 2 physiology,
abnormal dendritic cell physiology,
abnormal kidney morphology,
abnormal leukocyte physiology,
abnormal lymphocyte physiology,
abnormal memory T cell physiology,
abnormal plasmacytoid dendritic cell physiology,
abnormal susceptibility to infection,
abnormal thymocyte activation,
decreased CD4-positive, alpha beta T cell number,
decreased IgG1 level,
decreased IgG2a level,
decreased IgG2b level,
decreased IgG3 level,
decreased T cell proliferation,
decreased cytotoxic T cell cytolysis,
decreased eosinophil cell number,
decreased granulocyte number,
decreased interferon-gamma secretion,
decreased interleukin-13 secretion,
decreased interleukin-17 secretion,
decreased interleukin-21 secretion,
decreased interleukin-4 secretion,
decreased susceptibility to autoimmune diabetes,
decreased susceptibility to type IV hypersensitivity reaction,
granulomatous inflammation,
immune system phenotype,
impaired eosinophil recruitment,
impaired natural killer cell mediated cytotoxicity,
increased interferon-gamma secretion,
increased susceptibility to experimental autoimmune encephalomyelitis
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View all ortholog results at Monarch
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