Depression, Dysarthria, Frontal lobe dementia, Generalized hypotonia, Gliosis, Global developmental delay, Hydrocephalus, Hyperreflexia, Hypocalcemia, Kyphosis, Leukoencephalopathy, Macrocephaly, Memory impairment, Mental deterioration, Metaphyseal widening, Mutism, Neurodegeneration, Neuronal loss in central nervous system, Optic atrophy, Osteopetrosis, Periventricular heterotopia, Platyspondyly, Poor speech, Postural instability, Rigidity, Seizure, Shuffling gait, Spastic tetraplegia, Spasticity, Ventriculomegaly, Visual impairment

abnormal macrophage differentiation, abnormal mammary gland growth during pregnancy, abnormal osteoblast morphology, abnormal osteoclast differentiation, abnormal osteoclast morphology, abnormal osteocyte dendritic process morphology, abnormal osteocyte morphology, abnormal sexual interaction, abnormal skeleton physiology, abnormal testes secretion, absent Langerhans cell, absent teeth, axonal spheroids, deafness, decreased Langerhans cell number, decreased body size, decreased bone mineralization, decreased bone strength, decreased coping response, decreased macrophage cell number, delayed endochondral bone ossification, domed cranium, enlarged lateral ventricles, failure of bone resorption, hypermyelination, impaired olfaction, increased anxiety-related response, increased granulocyte number, increased oligodendrocyte progenitor number, increased spleen weight, increased width of hypertrophic chondrocyte zone, kinked tail, microgliosis, neuron degeneration, no abnormal phenotype detected, postnatal lethality, postnatal lethality, complete penetrance, premature death, prolonged diestrus, prolonged estrous cycle, reduced male fertility, round snout