nsmce2 Phenotypes

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Phenotypes

Gene Literature (0)

Nucleotides (66)

Interactants (17)

XB-GENEPAGE-6457748

Gene Symbol: nsmce2 Gene Name: NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (33 sources): Abdominal aortic aneurysm, Acanthosis nigricans, Acute pancreatitis, Cone-shaped epiphysis, Congenital blindness, Congestive heart failure, Diabetes mellitus, Elevated circulating alanine aminotransferase concentration, Elevated circulating aspartate aminotransferase concentration, Elevated circulating follicle stimulating hormone level, Elevated circulating luteinizing hormone level, Elevated hemoglobin A1c, Glucose intolerance, Glycosuria, Hepatic steatosis, Hypertension, Hypertriglyceridemia, Impaired glucose tolerance, Insulin resistance, Insulin-resistant diabetes mellitus, Malar prominence, Metaphyseal widening, Microcephaly, Micrognathia, Microretrognathia, Oral ulcer, Primary gonadal insufficiency, Retinal detachment, Severe short stature, Severe short-limb dwarfism, Skin tags, Slender long bone, Ventricular hypertrophy [+]
Mouse (27 sources): abnormal cell mass, abnormal cell nucleus morphology, abnormal chromosome morphology, abnormal embryo size, abnormal embryo turning, abnormal forebrain development, abnormal intestinal epithelium morphology, abnormal mitosis, abnormal placenta development, abnormal placenta morphology, abnormal thymus physiology, abnormal visceral yolk sac morphology, decreased embryo size, elevated level of mitotic sister chromatid exchange, embryonic lethality before implantation, embryonic lethality prior to tooth bud stage, increased cardiovascular system tumor incidence, increased cell nucleus count, increased histiocytic sarcoma incidence, increased liver tumor incidence, increased lymphoma incidence, increased tumor incidence, mitotic nondisjunction, no abnormal phenotype detected, premature aging, premature death, preweaning lethality, complete penetrance [+]
View all ortholog results at Monarch