Monarch Ortholog Phenotypes
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Human (9 sources):
Absent neutrophil lactoferrin,
Absent neutrophil specific granules,
Hyposegmentation of neutrophil nuclei,
Impaired neutrophil bactericidal activity,
Increased neutrophil mitochondria,
Increased neutrophil ribosomes,
Low neutrophil alkaline phosphatase,
Neutrophil nuclear clefts,
Recurrent bacterial infections
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Mouse (14 sources):
abnormal bone marrow cell morphology/development,
abnormal bone marrow morphology,
abnormal common myeloid progenitor cell morphology,
abnormal granulocyte differentiation,
abnormal myelopoiesis,
abnormal neutrophil differentiation,
decreased eosinophil cell number,
decreased granulocyte number,
enlarged lymph nodes,
impaired myelopoiesis,
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View all ortholog results at Monarch
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