| Monarch Ortholog Phenotypes
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Human (32 sources):
Abnormal thorax morphology,
Abnormality of the diaphragm,
Adducted thumb,
Arthrogryposis multiplex congenita,
Axial muscle weakness,
Bradykinesia,
Breech presentation,
Decreased fetal movement,
Dysphagia,
Edema of the dorsum of hands,
Facial diplegia,
Facial palsy,
Fetal akinesia sequence,
Flexion contracture,
Hypospadias,
Increased connective tissue,
Large fontanelles,
Low-set ears,
Micropenis,
Motor delay,
Multiple prenatal fractures,
Myofibrillar myopathy,
Nemaline bodies,
Ophthalmoplegia,
Polyhydramnios,
Premature birth,
Pulmonary hypoplasia,
Respiratory insufficiency,
Severe muscular hypotonia,
Skeletal muscle atrophy,
Thin ribs,
Type 1 muscle fiber predominance
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Mouse (11 sources):
abnormal Z line morphology,
abnormal sarcomere morphology,
abnormal skeletal muscle morphology,
decreased body size,
decreased skeletal muscle fiber size,
impaired skeletal muscle contractility,
increased skeletal muscle cell apoptosis,
postnatal lethality, complete penetrance,
preweaning lethality, incomplete penetrance,
slow postnatal weight gain,
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.