sppl2a Phenotypes

Phenotypes

XB-GENEPAGE-993494

Gene Symbol: sppl2a Gene Name: signal peptide peptidase like 2A

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: sppl2a assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (26 sources): abnormal class switch recombination, abnormal humoral immune response, abnormal mature B cell morphology, abnormal transitional stage B cell morphology, arrested B cell differentiation, decreased B cell proliferation, decreased B-1 B cell number, decreased B-2 B cell number, decreased IgG1 level, decreased IgG2a level, decreased IgG2b level, decreased IgG3 level, decreased Peyer's patch number, decreased activation-induced B cell apoptosis, decreased follicular B cell number, decreased marginal zone B cell number, decreased mature B cell number, decreased myeloid dendritic cell number, decreased plasmacytoid dendritic cell number, decreased response to antigen, decreased transitional stage T2 B cell number, decreased transitional stage T3 B cell number, hematopoietic system phenotype, immune system phenotype, small Peyer's patches, small spleen [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (26 sources): abnormal class switch recombination, abnormal humoral immune response, abnormal mature B cell morphology, abnormal transitional stage B cell morphology, arrested B cell differentiation, decreased B cell proliferation, decreased B-1 B cell number, decreased B-2 B cell number, decreased IgG1 level, decreased IgG2a level, [+]