| Monarch Ortholog Phenotypes
|
Human (38 sources):
Abnormal fear-induced behavior,
Abnormal involuntary eye movements,
Abnormal pyramidal sign,
Anxiety,
Apathy,
Aspiration,
Axial hypotonia,
Blindness,
Cerebral atrophy,
Cherry red spot of the macula,
Chorea,
Cognitive impairment,
Dementia,
Developmental regression,
Dystonia,
Exaggerated startle response,
Failure to thrive,
GM2-ganglioside accumulation,
Generalized hypotonia,
Glabellar reflex,
Global developmental delay,
Hyperacusis,
Hyperreflexia,
Hypotonia,
Inappropriate behavior,
Infantile axial hypotonia,
Loss of speech,
Neurodegeneration,
Paralysis,
Poor head control,
Primitive reflex,
Progressive spastic quadriplegia,
Pseudobulbar signs,
Punctate periventricular T2 hyperintense foci,
Seizure,
Short stature,
Spastic tetraparesis,
Spasticity
[+]
|
|
Mouse (10 sources):
abnormal Purkinje cell morphology,
abnormal amygdala morphology,
abnormal cerebellar cortex morphology,
abnormal cerebellar granule cell morphology,
abnormal cerebellar granule layer morphology,
abnormal cerebellar molecular layer,
abnormal cerebral cortex pyramidal cell morphology,
abnormal entorhinal cortex morphology,
abnormal olfactory cortex morphology,
impaired passive avoidance behavior
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.