Monarch Ortholog Phenotypes
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Mouse (22 sources):
abnormal macrophage physiology,
decreased glycogen catabolism rate,
decreased macrophage cell number,
endocrine/exocrine gland phenotype,
eyelids open at birth,
hematopoietic system phenotype,
impaired macrophage phagocytosis,
increased circulating amylase level,
increased circulating interleukin-1 beta level,
increased circulating interleukin-18 level,
increased circulating interleukin-6 level,
increased circulating lactate dehydrogenase level,
increased circulating tumor necrosis factor level,
increased interleukin-1 beta secretion,
increased interleukin-18 secretion,
increased macrophage apoptosis,
increased sensitivity to induced cell death,
increased susceptibility to endotoxin shock,
increased susceptibility to induced pancreatitis,
neonatal lethality, complete penetrance,
pancreas necrosis,
premature death
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