Bruxism, Bulbous nose, Camptodactyly, Clinodactyly, Coarse facial features, Cone-shaped epiphyses of the phalanges of the hand, Delayed skeletal maturation, Dental crowding, Downslanted palpebral fissures, Downturned corners of mouth, Drooling, Dry skin, Failure to thrive, Failure to thrive in infancy, Feeding difficulties in infancy, Hyperactivity, Hypertelorism, Hypoplastic nipples, Inappropriate crying, Infantile muscular hypotonia, Intellectual disability, Low-set ears, Microcephaly, Microtia, Midface retrusion, Nail dystrophy, Periorbital hyperpigmentation, Poor speech, Recurrent otitis media, Round face, Sacral dimple, Scaphocephaly, Seizure, Self-injurious behavior, Severe global developmental delay, Short palpebral fissure, Short proximal phalanx of the 2nd finger, Short proximal phalanx of the 5th finger, Short stature, Sleep-wake cycle disturbance, Small nail, Smooth philtrum, Stereotypical body rocking, Strabismus, Thick lower lip vermilion, Thick vermilion border, Thin upper lip vermilion, Thrombocytopenia, Tongue thrusting