Degeneration of the lateral corticospinal tracts, Depression, Difficulty in tongue movements, Dysarthria, Dysphagia, Dyspnea, Emotional lability, Fasciculations, Fatigable weakness of bulbar muscles, Fatigable weakness of respiratory muscles, Fatigable weakness of swallowing muscles, Fatigue, Gait imbalance, Generalized muscle weakness, Hyperreflexia, Laryngospasm, Loss of speech, Muscle spasm, Muscle weakness, Nausea and vomiting, Neurodegeneration, Pain, Pallor, Paralysis, Pseudobulbar affect, Pseudobulbar paralysis, Respiratory insufficiency, Saccadic smooth pursuit, Sensory neuropathy, Skeletal muscle atrophy, Sleep apnea, Spastic dysarthria, Spastic gait, Spastic tetraparesis, Spasticity, Spasticity of facial muscles, Spasticity of pharyngeal muscles, Xerostomia

abnormal facial motor nucleus morphology, abnormal fat pad morphology, abnormal gas homeostasis, abnormal glycerol level, abnormal hypoglossal nucleus morphology, abnormal lipid homeostasis, abnormal locomotor activation, abnormal mitochondrial physiology, abnormal motor capabilities/coordination/movement, abnormal motor neuron innervation pattern, abnormal muscle fiber morphology, abnormal muscle regeneration, abnormal neuron physiology, abnormal oculomotor nucleus morphology, abnormal retina ganglion layer morphology, abnormal retina nerve fiber layer morphology, abnormal retina rod cell outer segment morphology, abnormal spinal cord dorsal horn morphology, abnormal spinal cord ventral horn morphology, abnormal trigeminal motor nucleus morphology, aphagia, behavior/neurological phenotype, cochlear ganglion degeneration, cochlear hair cell degeneration, cochlear inner hair cell degeneration, cochlear outer hair cell degeneration, deafness, decreased a-wave amplitude, decreased b-wave amplitude, decreased cardiac muscle contractility, decreased common myeloid progenitor cell number, decreased corpora lutea number, decreased erythrocyte cell number, decreased fibroblast proliferation, decreased grip strength, decreased hemoglobin content, decreased litter size, decreased locomotor activity, decreased mature ovarian follicle number, decreased motor neuron number, decreased respiratory quotient, decreased retina ganglion cell number, decreased retina inner nuclear layer thickness, decreased white adipose tissue amount, dilated mitochondria, disorganized mitochondrial cristae, disorganized retina inner nuclear layer, disorganized retina outer nuclear layer, enhanced behavioral response to xenobiotic, enhanced lipolysis, hindlimb paralysis, homeostasis/metabolism phenotype, hyporesponsive to tactile stimuli, impaired adaptive thermogenesis, impaired balance, impaired ovarian folliculogenesis, increased circulating glucose level, increased circulating interleukin-6 level, increased circulating ketone body level, increased circulating tumor necrosis factor level, increased extensor digitorum longus weight, increased fibroblast apoptosis, increased gastrocnemius weight, increased hepatocellular carcinoma incidence, increased interleukin-6 secretion, increased liver tumor incidence, increased myocardial infarct size, increased or absent threshold for auditory brainstem response, increased oxygen consumption, increased quadriceps weight, increased sensitivity to xenobiotic induced morbidity/mortality, increased skeletal muscle mass, increased soleus weight, increased susceptibility to age-related hearing loss, increased susceptibility to noise-induced hearing loss, increased thermal nociceptive threshold, increased tibialis anterior weight, increased tumor necrosis factor secretion, lethality, incomplete penetrance, microgliosis, muscle degeneration, muscle phenotype, nervous system phenotype, organ of Corti degeneration, oxidative stress, pillar cell degeneration, positive geotaxis, premature death, reduced female fertility, retina photoreceptor degeneration, small ovary, suppressed circulating follicle stimulating hormone level, thin retina outer nuclear layer, thin stria vascularis, weakness