abnormal osteoclast physiology, abnormal physiological neovascularization, abnormal placenta labyrinth morphology, abnormal platelet activation, abnormal platelet dense granule physiology, abnormal thrombosis, abnormal trophoblast giant cell morphology, abnormal tumor pathology, abnormal tumor susceptibility, abnormal tumor vascularization, abnormal uterine environment, cardiac hypertrophy, decreased cardiac muscle contractility, decreased collagen level, decreased erythrocyte cell number, decreased hematocrit, decreased hemoglobin content, decreased keratinocyte proliferation, decreased left ventricle systolic pressure, decreased macrophage cell number, decreased osteoclast cell number, decreased susceptibility to induced thrombosis, dermatitis, enhanced wound healing, immune system phenotype, impaired macrophage chemotaxis, increased angiogenesis, increased compact bone thickness, increased heart weight, increased left ventricle diastolic pressure, increased left ventricle weight, increased mean corpuscular hemoglobin, increased osteoclast cell number, increased response of heart to induced stress, increased trabecular bone thickness, increased trabecular bone volume, increased transforming growth factor beta level, increased tumor growth/size, maternal effect, no abnormal phenotype detected, osteosclerosis, pale placenta, perinatal lethality, incomplete penetrance, postnatal lethality, incomplete penetrance, pregnancy-related premature death, premature death, reduced female fertility, renal necrosis, skin hemorrhage, uterine hemorrhage, vision/eye phenotype