trmu Phenotypes

Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Phenotypes

Gene Literature (0)

Nucleotides (96)

Interactants (7)

XB-GENEPAGE-1010590

Gene Symbol: trmu Gene Name: tRNA mitochondrial 2-thiouridylase

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: trmu assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (49 sources): Abdominal distention, Abnormality of the cardiovascular system, Abnormality of the coagulation cascade, Abnormality of the liver, Abnormality of the nervous system, Acute hepatic failure, Areflexia, Cytochrome C oxidase-negative muscle fibers, Decreased activity of mitochondrial complex I, Decreased plasma carnitine, Delayed gross motor development, Elevated circulating creatine kinase concentration, Elevated circulating hepatic transaminase concentration, Facial palsy, Failure to thrive, Feeding difficulties, Feeding difficulties in infancy, Generalized hypotonia, Hepatomegaly, High palate, Hyperbilirubinemia, Hyporeflexia, Hypotonia, Increased circulating lactate concentration, Increased muscle glycogen content, Increased muscle lipid content, Increased serum pyruvate, Jaundice, Lactic acidosis, Macroglossia, Macrovesicular hepatic steatosis, Microvesicular hepatic steatosis, Mildly elevated creatine kinase, Mitochondrial myopathy, Mitochondrial respiratory chain defects, Muscle fiber hypertrophy, Muscle weakness, Myopathic facies, Myopathy, Nasogastric tube feeding in infancy, Neck muscle weakness, Poor suck, Ragged-red muscle fibers, Respiratory distress, Respiratory failure requiring assisted ventilation, Respiratory insufficiency due to muscle weakness, Severe lactic acidosis, Ventilator dependence with inability to wean, Vomiting [+]
Mouse (14 sources): abnormal mitochondrial crista morphology, abnormal mitochondrial physiology, abnormal nucleotide metabolism, decreased circulating amylase level, embryonic lethality between implantation and somite formation, complete penetrance, homeostasis/metabolism phenotype, increased cell nucleus count, increased circulating alanine transaminase level, increased circulating aspartate transaminase level, increased circulating lactate dehydrogenase level, increased circulating lactate level, increased hepatocyte karyomegaly, increased mitochondrial DNA content, increased mitochondrial size [+]
View all ortholog results at Monarch