| Monarch Ortholog Phenotypes
|
Human (29 sources):
Agammaglobulinemia,
Arthritis,
Bronchiectasis,
Cellulitis,
Chronic otitis media,
Conjunctivitis,
Cough,
Dehydration,
Diarrhea,
Epicanthus,
Failure to thrive,
Fatigue,
Fever,
Hepatitis,
High palate,
Hypertelorism,
Immunodeficiency,
Malabsorption,
Meningitis,
Neutropenia,
Osteomyelitis,
Recurrent infections,
Recurrent respiratory infections,
Recurrent skin infections,
Sepsis,
Sinusitis,
Skin rash,
Verrucae,
obsolete External ear malformation
[+]
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Mouse (43 sources):
abnormal T cell differentiation,
abnormal T cell selection,
abnormal craniofacial morphology,
abnormal embryo size,
abnormal fat cell morphology,
abnormal renal tubule morphology,
abnormal seminal vesicle morphology,
abnormal skeletal muscle morphology,
abnormal thymus apoptosis,
abnormal thymus medulla morphology,
abnormal thymus morphology,
abnormal thymus physiology,
absent corpus luteum,
absent thymus corticomedullary boundary,
adipose tissue phenotype,
decreased CD4-positive, alpha beta T cell number,
decreased DN2 thymocyte number,
decreased DN3 thymocyte number,
decreased DN4 thymocyte number,
decreased T cell proliferation,
decreased double-negative T cell number,
decreased double-positive T cell number,
decreased epididymal fat pad weight,
decreased immature B cell number,
decreased inguinal fat pad weight,
decreased marginal zone B cell number,
decreased pre-B cell number,
decreased thymocyte number,
decreased transitional stage B cell number,
enlarged lung,
homeostasis/metabolism phenotype,
increased IgG2a level,
increased energy expenditure,
increased pro-B cell number,
increased regulatory T cell number,
increased susceptibility to diet-induced obesity,
increased thymocyte apoptosis,
premature death,
prenatal lethality, incomplete penetrance,
preweaning lethality, complete penetrance,
small spleen,
small thymus,
small thymus cortex
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.